Results 171 to 180 of about 12,783 (215)

Orexins/hypocretins and orexin receptors in apoptosis: a mini‐review

Acta Physiologica, 2010
AbstractAn unexpected and fascinating aspect of the neuropeptides orexins has recently emerged when it was shown that orexins acting at orexin receptors OX1R or OX2R induce dramatic apoptosis resulting in massive reduction in cell growth in various cancer cell lines.
M, Laburthe, T, Voisin, A, El Firar
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Localization of orexin A and orexin B in the porcine uterus

Reproductive Biology, 2012
The presence of orexins and their receptors in gonads indicate that these hormones participate in the control of reproductive functions. The aim of the study was to compare the expression of the prepro-orexin (PPO) gene in porcine endometrium and myometrium and the intensity of OXA- and OXB-immunoreactivity in the following uterine structures ...
Anna, Nitkiewicz, Nina, Smolinska, Anna, Maleszka, Marta, Kiezun, Tadeusz, Kaminski   +4 more
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Structure−Activity Studies of Orexin A and Orexin B at the Human Orexin 1 and Orexin 2 Receptors Led to Orexin 2 Receptor Selective and Orexin 1 Receptor Preferring Ligands

Journal of Medicinal Chemistry, 2004
The neuropeptides orexin A and B (also known as hypocretins) play an important role in many physiological and behavioral activities. Orexins are ligands of two closely related G-protein-coupled receptors, that are the named orexin 1 and orexin 2 receptors. To clearly identify the minimal ligand sequences required for receptor activation, we synthesized
Manja, Lang, Richard M, Söll, Franz, Dürrenberger, Frank M, Dautzenberg, Annette G, Beck-Sickinger   +4 more
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The Subthalamic Neurons are Activated by Both Orexin-A and Orexin-B

Neuroscience, 2018
The subthalamic nucleus is an important nucleus in the indirect pathway of the basal ganglia circuit and therefore is involved in motor control under both normal and pathological conditions. Morphological studies reveal that the subthalamic nucleus receives relatively dense orexinergic projections originating from the hypothalamus.
Qing, Sheng, Yan, Xue, Ying, Wang, An-Qi, Chen, Cui, Liu, Yun-Hai, Liu, Hong-Yan, Chu, Lei, Chen   +7 more
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Orexin A in swine corpus luteum

Domestic Animal Endocrinology, 2018
Orexin A (OXA) is a hypothalamic neuropeptide which acts on 2 known G-protein-coupled receptors. It has been demonstrated that OXA is a central molecular link between food intake and reproduction. More recently, its peripheral role has been investigated, and we demonstrated its involvement in regulating ovarian follicle function.
G, Basini, R, Ciccimarra, S, Bussolati, S, Grolli, L, Ragionieri, F, Ravanetti, M, Botti, F, Gazza, A, Cacchioli, R, Di Lecce, A M, Cantoni, F, Grasselli   +11 more
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Immunoreactive orexin-A in human plasma

Peptides, 2001
Orexin-A and orexin-B are newly discovered neuropeptides which are implicated in feeding behavior and arousal state. We studied immunoreactive(IR)-orexin-A concentrations in human plasma by radioimmunoassay. IR-orexin-A concentrations in plasma obtained from 17 healthy subjects in the morning were 1.94 +/- 0.24 pmol/liter (mean +/- SEM).
Z, Arihara, K, Takahashi, O, Murakami, K, Totsune, M, Sone, F, Satoh, S, Ito, T, Mouri   +7 more
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Orexin 2 receptor is involved in orexin A-induced hyperlocomotion in rats

Pharmacological Reports, 2019
The orexin system regulates various functions, including sleep/wake cycles, feeding, and cognition. Orexin A and orexin B are endogenous neuropeptides for both orexin 1 (OX1) and orexin 2 (OX2) receptors. Orexin A has a potent agonistic activity for both the receptors and is known to increase locomotor activity in rats.
Shunsuke, Maehara, Junji, Furukawa, Takumi, Ota   +2 more
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Relation between orexin A and epileptic seizures

Epilepsy Research, 2022
One of the unknown mechanisms in epilepsy pathogenesis is the involvement of the hypothalamic neuropeptide orexin. Although the relationship between orexin and sleep has been revealed, its effect in epilepsy has not been fully clarified. In this study, we aimed to show the relationship between orexin A and the seizures that occur during sleep and ...
Gokce Ayhan, Arslan, Serap, Saygi, Ebru, Bodur, Cigdem, Cicek, F Irsel, Tezer   +4 more
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Expression of orexin-A and orexin receptors in the kidney and the presence of orexin-A-like immunoreactivity in human urine

Peptides, 2006
Orexin-A (hypocretin-1), a neuropeptide with stimulatory actions on arousal and appetite, was originally shown to be specifically expressed in the hypothalamus. We studied expression of orexin-A and orexin receptors in the kidney and the presence of orexin-A-like immunoreactivity in human urine.
Kazuhiro, Takahashi, Zenei, Arihara, Takashi, Suzuki, Masahiko, Sone, Kumi, Kikuchi, Hironobu, Sasano, Osamu, Murakami, Kazuhito, Totsune   +7 more
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Structure–activity analysis of truncated orexin-A analogues at the orexin-1 receptor

Bioorganic & Medicinal Chemistry Letters, 2001
Truncated peptide analogues of orexin-A were prepared and their biological activity assesed at the orexin-1 receptor. Progressive N-terminal deletions identified the minimum C-terminal sequence required for maintaining a significant agonist effect, whilst an alanine scan and other pertinent substitutions identified key side-chain and stereochemical ...
J G, Darker, R A, Porter, D S, Eggleston, D, Smart, S J, Brough, C, Sabido-David, J C, Jerman   +6 more
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