Results 41 to 50 of about 61,131 (327)

Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity

Bioactive Materials, 2021
Despite showing a great promise in the field of nanomedicine, nanoparticles have gained a significant attention from regulatory agencies regarding their possible adverse health effects upon environmental exposure.
Rick Xing Ze Lu, Milica Radisic
doaj   +1 more source

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies [PDF]

, 2019
The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many pharmaceuticals and therapeutic antibodies to the central nervous system.
A Doran, A Herland, A Mahringer, A Regina, A Triantafyllou, A Wolff, AV Zhdanov, B Feng, B Oller-Salvia, B Rochat, B Srinivasan, BB Weksler, BD Gastfriend, BM Maoz, C Greene, EA Neuwelt, EG Geier, EK Hollmann, ES Lippmann, ES Lippmann, FC Thomas, FE O’Brien, GD Vatine, GL Semenza, H Abdollahi, H Burger, H Sade, HC Helms, JA Brown, JC Kalvass, JF Chen, JM Stenman, K Lauschke, KH Benam, KM Baeten, KS Kim, L Cucullo, L Tang, Louise Delsing, M Campisi, M Demeule, M Jorfi, M Li, M Ribecco-Lutkiewicz, ME Katt, ME Katt, MJ Stebbins, NJ Abbott, NR Wevers, OYF Henry, Q Wang, Q Zhang, R Cecchelli, R Daneman, R Shawahna, RM Linville, S Chakraborty, S Cisternino, S Kusuma, S Roman-Goldstein, S Sances, SN Bhatia, SW Lee, T Ohnishi, TR Doeppner, V Kiviniemi, W Löscher, W-L Yeh, WM Pardridge, WP Mason, Y Han, YI Wang, YJ Yu   +72 more
core   +1 more source

Microfluidic-Chip-Integrated Biosensors for Lung Disease Models

Biosensors, 2021
Lung diseases (e.g., infection, asthma, cancer, and pulmonary fibrosis) represent serious threats to human health all over the world. Conventional two-dimensional (2D) cell models and animal models cannot mimic the human-specific properties of the lungs.
Shuang Ding, Haijun Zhang, Xuemei Wang
doaj   +1 more source

Organoids, organs-on-chips and other systems, and microbiota [PDF]

, 2017
The human gut microbiome is considered an organ in its entirety and has been the subject of extensive research due to its role in physiology, metabolism, digestion, and immune regulation.
Evans, Samantha, May, Stephanie, Parry, Lee   +2 more
core   +2 more sources

A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems

Bioengineering, 2021
Drug and chemical development along with safety tests rely on the use of numerous clinical models. This is a lengthy process where animal testing is used as a standard for pre-clinical trials.
Luana A Osório, Elisabete Silva, R. Mackay   +2 more
semanticscholar   +1 more source

Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS)

Frontiers in Cell and Developmental Biology, 2021
Identification and approval of new drugs for use in patients requires extensive preclinical studies and clinical trials. Preclinical studies rely on in vitro experiments and animal models of human diseases.
Mridu Malik, Mridu Malik, Yang Yang, Yang Yang, Parinaz Fathi, Gretchen J. Mahler, Mandy B. Esch   +6 more
doaj   +1 more source

EHV-1 Pathogenesis: Current in vitro Models and Future Perspectives [PDF]

, 2019
Primary infection and pathogenesis of equine herpesvirus type 1 (EHV-1) require an intricate interaction of virus with the mucosal epithelium, mononuclear cells and the vascular endothelium.
Azab, Walid, Kamel, Mohamed, Osterrieder, Klaus, Pavulraj, Selvaraj   +3 more
core   +1 more source

Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function. [PDF]

, 2019
With extended stays aboard the International Space Station (ISS) becoming commonplace, there is a need to better understand the effects of microgravity on cardiac function. We utilized human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
Agrawal, Azakie, Baio, Becker, Bergmann, Burridge, Camberos, Connor, Drosatos, Fermini, Fritsch-Yelle, Garrett-Bakelman, Gauthier, Huebsch, Hughson, Jha, Kim, Kwon, Oikonomopoulos, Perhonen, Rogers, Sharma, Sharma, Sharma, Sides, Spotnitz, Sun, Thomason, Wnorowski, Wu, Yu   +30 more
core   +1 more source

Application of a Human Blood Brain Barrier Organ-on-a-Chip Model to Evaluate Small Molecule Effectiveness against Venezuelan Equine Encephalitis Virus

Viruses, 2022
The blood brain barrier (BBB) is a multicellular microenvironment that plays an important role in regulating bidirectional transport to and from the central nervous system (CNS).
Niloufar A. Boghdeh, Kenneth H. Risner, Michael D Barrera, Clayton M. Britt, D. Schaffer, Farhang Alem, Jacquelyn A. Brown, J. Wikswo, Aarthi Narayanan   +8 more
semanticscholar   +1 more source

Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction [PDF]

, 2016
Microfluidic organ-on-a-chip technology aims to replace animal toxicity testing, but thus far has demonstrated few advantages over traditional methods.
Bavli, D, Cohen, M, Ezra, E, Jaeger, M, Levy, G, Nahmias, Y, Prill, S, Vanfleteren, Jan, Vinken, M   +8 more
core   +2 more sources