Results 11 to 20 of about 5,802,173 (351)

Fibrin-genipin adhesive hydrogel for annulus fibrosus repair: performance evaluation with large animal organ culture, in situ biomechanics, and in vivo degradation tests [PDF]

European Cells & Materials, 2014
Annulus fibrosus (AF) defects from annular tears, herniation, and discectomy procedures are associated with painful conditions and accelerated intervertebral disc (IVD) degeneration.
M Likhitpanichkul, M Dreischarf, S Illien-Junger, BA Walter, T Nukaga, RG Long, D Sakai, AC Hecht, JC Iatridis   +8 more
doaj   +2 more sources

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents [PDF]

Lab on a Chip, 2015
Systemic absorption and metabolism of drugs in the small intestine, metabolism by the liver as well as excretion by the kidney are key determinants of efficacy and safety for therapeutic candidates. However, these systemic responses of applied substances
Bauer, Sophie, Drewell, Christopher, Hasenberg, Tobias, Hübner, Juliane, Lauster, Roland, Lindner, Marcus, Lorenz, Alexandra K., Marx, Uwe, Maschmeyer, Ilka, Ramme, Anja P., Sambo, Naomia Sisoli, Schimek, Katharina, Sonntag, Frank, Thomas, Alexander   +13 more
core   +2 more sources

10−7 M genistein partially alleviates 10−7 M MEHP unfavorable effects in a new modified fetal rat testis culture system

Frontiers in Cell and Developmental Biology, 2022
Background: Recent studies revealed that some common endocrine-disrupting chemicals (EDCs) including phthalates and phytoestrogens may exhibit low-dose effects properties.
Tong-Dian Zhang, Tong-Dian Zhang, Yu-Bo Ma, Ming Gao, He-Cheng Li, Zi-Ming Wang, Tie Chong, Lian-Dong Zhang   +7 more
doaj   +1 more source

Pathogenesis of Neisseria gonorrhoeae and the Host Defense in Ascending Infections of Human Fallopian Tube

Frontiers in Immunology, 2018
Neisseria gonorrhoeae is an obligate human pathogen that causes mucosal surface infections of male and female reproductive tracts, pharynx, rectum, and conjunctiva. Asymptomatic or unnoticed infections in the lower reproductive tract of women can lead to
Jonathan D. Lenz, Joseph P. Dillard
doaj   +1 more source

SARS-CoV-2 Omicron Induces Enhanced Mucosal Interferon Response Compared to other Variants of Concern, Associated with Restricted Replication in Human Lung Tissues

Viruses, 2022
SARS-CoV-2 Omicron variant has been characterized by decreased clinical severity, raising the question of whether early variant-specific interactions within the mucosal surfaces of the respiratory tract could mediate its attenuated pathogenicity.
Or Alfi, Marah Hamdan, Ori Wald, Arkadi Yakirevitch, Ori Wandel, Esther Oiknine-Djian, Ben Gvili, Hadas Knoller, Noa Rozendorn, Hadar Golan Berman, Sheera Adar, Olesya Vorontsov, Michal Mandelboim, Zichria Zakay-Rones, Menachem Oberbaum, Amos Panet, Dana G. Wolf   +16 more
doaj   +1 more source

Usefulness of the organ culture system in the in vitro diagnosis of coeliac disease: A multicentre study [PDF]

, 2006
Objective. Diagnosis of coeliac disease is based on the presence of villous atrophy which recovers following a gluten-free diet. The presence of circulating antiendomysial antibodies as well as their disappearance after a gluten-free diet supports the ...
Aliaga, E., Anania, M., Bai, J., Bardella, M., Barisani, D., Bravi, E., Calabr\uf2, A., Carroccio, A., DI PRIMA, L., Di Tola, M., Gasparin, M., Picarelli, A., Renzi, D., Ribes Koninckx, C., Sabbatella, L., Sugai, E.   +15 more
core   +1 more source

Development of an Ex Vivo Organ Culture Technique to Evaluate Probiotic Utilization in IBD [PDF]

, 2016
The consistent technical and conceptual progress in the study of the microbiota has led novel impulse to the research for therapeutical application of probiotic bacteria in human pathologies, such as inflammatory bowel disease (IBD).
DELLE FAVE, Gianfranco, Lanini, Claudio, Martorelli, M, Pagnini, C   +3 more
core   +1 more source

Lactobacillus casei DG and its postbiotic reduce the inflammatory mucosal response: an ex-vivo organ culture model of post-infectious irritable bowel syndrome

BMC Gastroenterology, 2017
BackgroundThe evidence on the role of gut microbiota in post-infectious irritable bowel syndrome (PI-IBS) is convincing. Lactobacillus spp. positively affect IBS symptoms, although the mechanisms through which probiotics exert their beneficial effects ...
D. Compare, A. Rocco, P. Coccoli, D. Angrisani, C. Sgamato, B. Iovine, U. Salvatore, G. Nardone   +7 more
semanticscholar   +1 more source

The untapped potential of plant thin cell layers [PDF]

, 2015
Thin cell layers (TCLs), which contain a small number of cells or tissues, are explants excised from different organs (stems, leaves, roots, inflorescences, flowers, cotyledons, hypocotyls/epicotyls, and embryos).
Botero Giraldo, Della Rovere, Della Rovere, Dhir, Dobránszki, Falasca, Gomes, Mao, Monja, Raomai, Teixeira, Teixeira, Teixeira, Teixeira, Teixeira, Tran   +15 more
core   +1 more source

Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture

PLoS Biology, 2018
Autophagy plays a crucial role in health and disease, regulating central cellular processes such as adaptive stress responses, differentiation, tissue development, and homeostasis.
Chiara Parodi, J. Hardman, Giulia Allavena, R. Marotta, T. Catelani, M. Bertolini, R. Paus, B. Grimaldi   +7 more
semanticscholar   +1 more source