Results 21 to 30 of about 1,028,257 (352)

A novel and cost-effective ex vivo orthotopic model for the study of human breast cancer in mouse mammary gland organ culture

Biology Open, 2020
Mouse mammary organ culture (MMOC) is used to evaluate the efficacy of chemopreventive agents against the development of carcinogen-induced preneoplastic lesions and is highly correlative to in vivo carcinogenesis models. Here, we developed a new ex vivo
Akash Gupta, Geetanjali Gupta, Rajeshwari R. Mehta, David Z. Ivancic, Rashidra R. Walker, Jankiben R. Patel, Karen M. Gallegos, A. Michael Davidson, Seema A. Khan, Rajendra G. Mehta, Syreeta L. Tilghman   +10 more
doaj   +1 more source

Integration of systems biology with organs-on-chips to humanize therapeutic development [PDF]

, 2017
"Mice are not little people" - a refrain becoming louder as the gaps between animal models and human disease become more apparent. At the same time, three emerging approaches are headed toward integration: powerful systems biology analysis of cell-cell ...
Chen, Wen Li, Cirit, Murat, Clark, Amanda M., Edington, Collin D, Griffith, Linda G, Trumper, David L, Wells, Alan   +6 more
core   +1 more source

Ex vivo intervertebral disc cultures: degeneration-induction methods and their implications for clinical translation [PDF]

European Cells & Materials, 2023
Because low back pain is frequently a result of intervertebral disc degeneration (IVDD), strategies to regenerate or repair the IVD are currently being investigated.
E Salzer, TC Schmitz, VHM Mouser, A Vernengo, B Gantenbein, JU Jansen, C Neidlinger-Wilke, H-J Wilke, S Grad, CL Le Maitre, MA Tryfonidou, K Ito   +11 more
doaj   +1 more source

Geometric control of myogenic cell fate. [PDF]

, 2006
This work combines expertise in stem cell biology and bioengineering to define the system for geometric control of proliferation and differentiation of myogenic progenitor cells.
Conboy IM, Disatnik MH, Elena M de Juan-Pardo, Irina M Conboy, Massague J, Mike Bao-Trong Hoang, Miller KJ, Partridge TA, Seale P, Tidball JG   +9 more
core   +3 more sources

Acylated and unacylated ghrelin directly regulate ß-3 stimulated lipid turnover in rodent subcutaneous and visceral adipose tissue ex vivo but not in vivo

Adipocyte, 2019
Ghrelin has garnered interest as a gut-derived regulator of lipid metabolism, beyond its classical roles in driving appetite and growth hormone release.
Daniel T. Cervone, Justin Sheremeta, Emily N. Kraft, David J. Dyck   +3 more
doaj   +1 more source

Органная культура Сибири XIX - первой четверти XX века в контексте конфессиональной и художественной деятельности переселенцев западно-христианского вероисповедания

Вестник музыкальной науки, 2014
В статье автор обращается к одной из актуальных и неизученных проблем музыкального сибиреведения, связанной с историей органной культуры в Сибири дореволюционного времени и ролью представителей римско-католической и евангелическо-лютеранской конфессий в ...
Пронина, Анна Николаевна
doaj   +1 more source

Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism [PDF]

, 2017
AIM: To evaluate the effects of the non-selective, non-steroidal anti-inflammatory drug (NSAID) acetylsalicylic acid (ASA), on ex vivo embryonic kidney growth and development.
Elmes, Matthew J., Gardner, David S., Sparrow, Alexander J., Welham, Simon J.M.   +3 more
core   +2 more sources

Observation of the Epithelial Cell Behavior in the Nasal Septum During Primary Palate Closure in Mice

Frontiers in Physiology, 2020
Epithelial fusion is critical in palatogenesis, and incomplete fusion results in various type of facial cleft, depending on the region that fails to fuse.
Sayuri Yamamoto, Hiroshi Kurosaka, Jiro Miura, Gozo Aoyama, Safiye Esra Sarper, Safiye Esra Sarper, Ayaka Oka, Toshihiro Inubushi, Kohei Nakatsugawa, Yu Usami, Satoru Toyosawa, Takashi Yamashiro   +11 more
doaj   +1 more source

Establishing monoxenic culture of arbuscular mycorrhizal fungus Glomus intraradices through root organ culture [PDF]

, 2014
Arbuscular mycorrhizal fungi are soil fungi distributed worldwide, forming symbiosis with most of the vascular plants for their growth and survival, which is used for sustainable agriculture and ecosystem management.
Kumar, K., Kumutha, K., Marimuthu, P., Srinivasan, M.   +3 more
core   +2 more sources

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and b1-integrin activation [PDF]

, 2018
Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Alve, S, Balistreri, G, Gramolelli, S, Hautaniemi, S, Icay, K, Ivaska, J, Lehti, K, Niiranen, O, Ojala, PM, Paatero, I, Pekkonen, P, Perälä, N, Repo, P, Saharinen, P, Taiwo, A, Tatti-Bugaeva, O, Tuohinto, K, Zinovkina, N   +17 more
core   +1 more source