Results 21 to 30 of about 5,802,173 (351)

The Efficacy of Sunitinib Treatment of Renal Cancer Cells Is Associated with the Protein PHAX In Vitro

Biology, 2020
Anti-angiogenic agents, such as the multi-tyrosine kinase inhibitor sunitinib, are key first line therapies for metastatic clear cell renal cell carcinoma (ccRCC), but their mechanism of action is not fully understood.
Rafia S. Al-Lamki, Nicholas J. Hudson, John R. Bradley, Anne Y. Warren, Tim Eisen, Sarah J. Welsh, Antony C. P. Riddick, Fiach C. O’Mahony, Arran Turnbull, Thomas Powles, SCOTRRCC Collaborative, Antonio Reverter, David J. Harrison, Grant D. Stewart   +13 more
doaj   +1 more source

Studies of intercellular invasion in vitro using rabbit peritoneal neutrophil granulocytes (PMNS). I. Role of contact inhibition of locomotion. [PDF]

, 1975
Intercellular invasion is the active migration of cells on one type into the interiors of tissues composed of cells of dissimilar cell types. Contact paralysis of locomotion is the cessation of forward extension of the pseudopods of a cell as a result of
Armstrong, Peter, Lackie, J
core   +1 more source

In vitro mouse spermatogenesis with an organ culture method in chemically defined medium

PLoS ONE, 2018
We previously reported the successful induction and completion of mouse spermatogenesis by culturing neonatal testis tissues. The culture medium consisted of α-minimum essential medium (α-MEM), supplemented with Knockout serum replacement (KSR) or ...
Hiroyuki Sanjo, Mitsuru Komeya, Takuya Sato, Takeru Abe, K. Katagiri, Hiroyuki Yamanaka, Yoko Ino, Noriaki Arakawa, H. Hirano, Tatsuma Yao, Yuta Asayama, A. Matsuhisa, M. Yao, T. Ogawa   +13 more
semanticscholar   +1 more source

A multi-organ-chip co-culture of liver and testis equivalents: a first step toward a systemic male reprotoxicity model.

Human Reproduction, 2020
STUDY QUESTION Is it possible to co-culture and functionally link human liver and testis equivalents in the combined medium circuit of a multi-organ chip? SUMMARY ANSWER Multi-organ-chip co-cultures of human liver and testis equivalents were maintained
Y. Baert, I. Ruetschle, W. Cools, A. Oehme, A. Lorenz, Uwe Marx, Ellen Goossens, I. Maschmeyer   +7 more
semanticscholar   +1 more source

A novel and cost-effective ex vivo orthotopic model for the study of human breast cancer in mouse mammary gland organ culture

Biology Open, 2020
Mouse mammary organ culture (MMOC) is used to evaluate the efficacy of chemopreventive agents against the development of carcinogen-induced preneoplastic lesions and is highly correlative to in vivo carcinogenesis models. Here, we developed a new ex vivo
Akash Gupta, Geetanjali Gupta, Rajeshwari R. Mehta, David Z. Ivancic, Rashidra R. Walker, Jankiben R. Patel, Karen M. Gallegos, A. Michael Davidson, Seema A. Khan, Rajendra G. Mehta, Syreeta L. Tilghman   +10 more
doaj   +1 more source

Integration of systems biology with organs-on-chips to humanize therapeutic development [PDF]

, 2017
"Mice are not little people" - a refrain becoming louder as the gaps between animal models and human disease become more apparent. At the same time, three emerging approaches are headed toward integration: powerful systems biology analysis of cell-cell ...
Chen, Wen Li, Cirit, Murat, Clark, Amanda M., Edington, Collin D, Griffith, Linda G, Trumper, David L, Wells, Alan   +6 more
core   +1 more source

Human multi-organ chip co-culture of bronchial lung culture and liver spheroids for substance exposure studies

Scientific Reports, 2020
Extrapolation of cell culture-based test results to in vivo effects is limited, as cell cultures fail to emulate organ complexity and multi-tissue crosstalk.
K. Schimek, S. Frentzel, K. Luettich, D. Bovard, Isabel Rütschle, Laura Boden, Felix Rambo, Hendrik Erfurth, Eva-Maria Dehne, A. Winter, U. Marx, J. Hoeng   +11 more
semanticscholar   +1 more source

Ex vivo intervertebral disc cultures: degeneration-induction methods and their implications for clinical translation [PDF]

European Cells & Materials, 2023
Because low back pain is frequently a result of intervertebral disc degeneration (IVDD), strategies to regenerate or repair the IVD are currently being investigated.
E Salzer, TC Schmitz, VHM Mouser, A Vernengo, B Gantenbein, JU Jansen, C Neidlinger-Wilke, H-J Wilke, S Grad, CL Le Maitre, MA Tryfonidou, K Ito   +11 more
doaj   +1 more source

Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism [PDF]

, 2017
AIM: To evaluate the effects of the non-selective, non-steroidal anti-inflammatory drug (NSAID) acetylsalicylic acid (ASA), on ex vivo embryonic kidney growth and development.
Elmes, Matthew J., Gardner, David S., Sparrow, Alexander J., Welham, Simon J.M.   +3 more
core   +2 more sources

Acylated and unacylated ghrelin directly regulate ß-3 stimulated lipid turnover in rodent subcutaneous and visceral adipose tissue ex vivo but not in vivo

Adipocyte, 2019
Ghrelin has garnered interest as a gut-derived regulator of lipid metabolism, beyond its classical roles in driving appetite and growth hormone release.
Daniel T. Cervone, Justin Sheremeta, Emily N. Kraft, David J. Dyck   +3 more
doaj   +1 more source