Results 91 to 100 of about 17,899 (265)

Variation in prevalence and intensity of macroparasites in moose and their interactions with winter tick load in eastern Canada

Wildlife Biology, EarlyView.
Wild animals are infected with a large diversity and abundance of parasites that can affect their behavior, growth, body condition, and ultimately their survival. Although the adverse effects of parasites and the mechanisms involved in the interactions between a host and its parasites are generally well studied, much less is known about the additive or
Catherine Pouchet, Christopher Fernandez‐Prada, Christian Dussault, Martin Leclerc, Jean‐Pierre Tremblay, Steeve D. Côté   +5 more
wiley   +1 more source

Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures

Acta Oto-Laryngologica, 2014
Conclusion: Inhibition of thioredoxin reductase (TrxR) may be a contributing factor in cisplatin-induced ototoxicity. Direct exposure of organ of Corti to cisplatin and oxaliplatin gives equal loss of hair cells. Objectives: Platinum-containing drugs are
P. Dammeyer, Victoria Hellberg, I. Wallin, G. Laurell, M. Shoshan, H. Ehrsson, Elias S. J. Arnér, M. Kirkegaard   +7 more
semanticscholar   +1 more source

A pan‐European citizen science study shows population size, climate and land use are related to biased morph ratios in the heterostylous plant Primula veris

Journal of Ecology, EarlyView.
A large‐scale citizen science study involving thousands of cowslip (Primula veris) observations from all over Europe revealed an unexpected prevalence of S‐morphs over L‐morphs, which was influenced by climatic as well as land use factors. Furthermore, general morph ratios were often unbalanced with the strongest shifts occurring in smaller populations.
Tsipe Aavik, Triin Reitalu, Marianne Kivastik, Iris Reinula, Sabrina Träger, Evelyn Uuemaa, Marta Barberis, Arjen Biere, Sílvia Castro, Sara A. O. Cousins, Anikó Csecserits, Eleftherios Dariotis, Živa Fišer, Grzegorz Grzejszczak, Cuong Nguyen Huu, Kertu Hool, Hans Jacquemyn, Margaux Julien, Marcin Klisz, Alexander Kmoch, Nikos Krigas, Attila Lengyel, Michael Lenhard, Desalew M. Moges, Zuzana Münzbergová, Ülo Niinemets, Baudewijn Odé, Hana Pánková, Meelis Pärtel, Ricarda Pätsch, Theodora Petanidou, Jan Plue, Radosław Puchałka, Froukje Rienks, Ioulietta Samartza, Julie K. Sheard, Bojana Stojanova, Joachim P. Töpper, Georgios Tsoktouridis, Spas Uzunov, Martin Zobel   +40 more
wiley   +1 more source

Timed conditional null of connexin26 in mice reveals temporary requirements of connexin26 in key cochlear developmental events before the onset of hearing

Neurobiology of Disease, 2015
Mutations in the Gjb2 gene, which encodes a gap junction protein connexin26 (Cx26), are the most prevalent form of hereditary deafness in humans and represent about half of non-syndromic congenital deafness cases in many ethnic populations.
Qing Chang, Wenxue Tang, Yeunjung Kim, Xi Lin   +3 more
doaj   +1 more source

Implication of GPRASP2 in the Proliferation and Hair Cell‐Forming of Cochlear Supporting Cells

Cell Proliferation, EarlyView.
Schematic diagram of GPRASP2‐mediated SCs proliferation and HCs formation. GPRASP2 deficiency results in increased lysosomal degradation of SMO. GPRASP2‐mediated SMO/GLI1 signalling promotes SC proliferation, which contributes to HC formation. GPRASP2‐mediated SMO/β‐catenin signalling is implicated in HCs fate specification and differentiation ...
Jing Cai, Kun Huang, Wenrui Li, Tianming Wang, Shen Yue, Zhibin Chen, Guangqian Xing, Qinjun Wei, Jun Yao, Xin Cao   +9 more
wiley   +1 more source

Identifying MicroRNAs Involved in Degeneration of the Organ of Corti during Age-Related Hearing Loss

PLoS ONE, 2013
MicroRNAs (miRNAs), a class of short non-coding RNAs that regulate the expression of mRNA targets, are important regulators of cellular senescence and aging.
Qian Zhang, Huizhan Liu, J. McGee, E. Walsh, G. Soukup, D. He   +5 more
semanticscholar   +1 more source

The cochlear apex demystified: Implications from synchrotron radiation phase‐contrast imaging and microscopy for cochlear implantation

Journal of Anatomy, EarlyView.
This study is the first to present the detailed cellular organization and three‐dimensional (3D) tonotopic arrangement of the human organ of Corti, spiral ganglion, and central modiolus using synchrotron radiation phase‐contrast imaging (SR‐PCI) with matched histological cross‐sections.
Hao Li, Rudolf Glueckert, Anneliese Schrott‐Fischer, Karin Staxäng, Hanif M. Ladak, Helge Rask‐Andersen, Sumit Agrawal   +6 more
wiley   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Catalytic Activity of Solution Additive Anions for Magnesite and Calcite Precipitation in Microwave‐Assisted Mineral Carbonation Experiments

Advanced Energy and Sustainability Research, Volume 6, Issue 9, September 2025.
Demonstrating anion‐catalyzed CO2 mineralization and microwave‐boosted carbonation, this study advances sustainable carbon capture and utilization technologies, mitigating climate change by promoting efficient magnesite and calcite precipitation from eco‐friendly processes.
Marcello Campione, Daniela D’Alessio, Mattia Corti, Giancarlo Capitani, Andrea Lucotti, Matteo Tommasini, Rossella Yivlialin, Lamberto Duò, Gianlorenzo Bussetti, Nadia Malaspina   +9 more
wiley   +1 more source

Sleep Quality and Cognitive Performance in Chronic Primary Musculoskeletal Pain: An Observational Study With Healthy Controls

European Journal of Pain, Volume 29, Issue 8, September 2025.
ABSTRACT Background Chronic primary musculoskeletal pain (CPMP) is a recently defined diagnosis characterised by persistent pain accompanied by emotional distress and/or functional disability. Although sleep disturbances and cognitive complaints are common in individuals with chronic pain, few studies have examined their relationship in CPMP, a ...
Alejandro Arévalo‐Martínez, Carlos Barbosa‐Torres, María Elena García‐Baamonde, César Luis Díaz‐Muñoz, Juan Manuel Moreno‐Manso   +4 more
wiley   +1 more source