Drug-induced stress granule formation protects sensory hair cells in mouse cochlear explants during ototoxicity [PDF]
Stress granules regulate RNA translation during cellular stress, a mechanism that is generally presumed to be protective, since stress granule dysregulation caused by mutation or ageing is associated with neurodegenerative disease.
Dawson, Sally J. +6 more
core +2 more sources
Circularly Polarized Near‐Infrared Electroluminescence from Chromium(III) Complex‐Based OLEDs
Electroluminescence is developed from a chromium(III) complex, showing near‐infrared circularly polarized emission at 726 and 747 nm. This highlights the promise of earth‐abundant chromium(III) complexes for advanced chiral optoelectronic applications in fields like medicine, security, and quantum communications. Abstract Organic light‐emitting diodes (
Maxime Poncet +6 more
wiley +1 more source
The roles of Irx3 and Irx5 in mammalian inner ear development [PDF]
Iroquois genes encode a family of transcription factors containing TALE class homeodomain. They are regarded as prepatterning genes in Drosophila sensory organ development. There are six members (Irx1Irx6) of Iroquois genes in mouse and human.
Chan, YS +6 more
core
A large‐scale citizen science study involving thousands of cowslip (Primula veris) observations from all over Europe revealed an unexpected prevalence of S‐morphs over L‐morphs, which was influenced by climatic as well as land use factors. Furthermore, general morph ratios were often unbalanced with the strongest shifts occurring in smaller populations.
Tsipe Aavik +40 more
wiley +1 more source
Mutations in the Gjb2 gene, which encodes a gap junction protein connexin26 (Cx26), are the most prevalent form of hereditary deafness in humans and represent about half of non-syndromic congenital deafness cases in many ethnic populations.
Qing Chang +3 more
doaj +1 more source
The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells [PDF]
Loss of full-length adenomatous polyposis coli (APC) protein correlates with the development of colon cancers in familial and sporadic cases. In addition to its role in regulating β-catenin levels in the Wnt signaling pathway, the APC protein is ...
Mackie, John B. +4 more
core +5 more sources
Chronic low‐concentration lead exposure accelerates the development of ARHL. Lead exposure mediates damage to cochlear sensory cells via the mitochondrial protease LONP1, leading to irreversible hearing loss. ABSTRACT Heavy metal ion exposure has become a global public health concern.
Xue Bai +10 more
wiley +1 more source
Selective Ablation of Cochlear Hair Cells Promotes Engraftment of Human Embryonic Stem Cells-derived Progenitors in The Mouse organ of Corti [PDF]
Hiroki Takeda +3 more
openalex +1 more source
IL-1α and TNF-α Down-Regulate CRH Receptor-2 mRNA Expression in the Mouse Heart [PDF]
Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II.
Coste, Sarah C. +4 more
core +2 more sources
A pH‐Responsive Synthetic Receptor for Switchable Binding of Carbohydrates
A diaminocarbazole macrocyclic receptor, designed for disaccharide recognition in water, exhibits distinct binding properties under alkaline versus neutral pH conditions. Carbohydrates are selectively recognized under alkaline conditions, whereas release of the bound guest occurs at physiological pH, effectively behaving as a pH‐switchable carbohydrate
Francesco Milanesi +4 more
wiley +1 more source

