Results 11 to 20 of about 38,853 (217)

Targeted cell interconversions reveal inner hair cell control of organ of Corti cytoarchitecture. [PDF]

Sci Adv
García-Gómez I, Webber JL, Soria-Izquierdo B, Clancy JC, Duggan A, Zhou Y, Murphey CP, Harriman TDM, Wang J, Cheatham MA, García-Añoveros J.   +10 more
europepmc   +2 more sources

MnTBAP, a peroxynitrite scavenger, attenuates cisplatin-induced apoptosis and cytotoxicity in organ of Corti cells. [PDF]

Toxicol Rep
Shahab M, Rosati R, Bhatia P, Doyon-Reale N, Jamesdaniel S.   +4 more
europepmc   +2 more sources

Unbalanced bidirectional radial stiffness gradients within the organ of Corti promoted by TRIOBP. [PDF]

Proc Natl Acad Sci U S A, 2022
Babahosseini H, Belyantseva IA, Yousaf R, Tona R, Hadi S, Inagaki S, Wilson E, Kitajiri SI, Frolenkov GI, Friedman TB, Cartagena-Rivera AX.   +10 more
europepmc   +3 more sources

Dysferlin Protein-Protein Interaction Pathways in the Organ of Corti and Spiral Ganglion Intersect with Alzheimer's Protein Pathways. [PDF]

Int J Mol Sci
Drescher MJ, Drescher DG, Khan KM, Hatfield JS, Hemani D.   +4 more
europepmc   +3 more sources

Cochlea cell-specific marker expression upon in vitro Hes1 knockdown [PDF]

Brazilian Journal of Medical and Biological Research, 2021
NOTCH pathway proteins, including the transcriptional factor HES1, play crucial roles in the development of the inner ear by means of the lateral inhibition mechanism, in which supporting cells have their phenotype preserved while they are prevented from
A.C. Batissoco, K. Lezirovitz, D.B. Zanatta, C.R.M.L. Hemza, L.R. Vasques, B.E. Strauss, R.C. Mingroni-Netto, L.A. Haddad, R.F. Bento, J. Oiticica   +9 more
doaj   +1 more source

Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation

Redox Report, 2023
Cisplatin-induced ototoxicity is caused by reactive oxygen species. It has been recognized that estradiol (E2) regulates redox balance. However, little is known about the protective mechanisms of E2 against cisplatin-induced ototoxicity.
Masahiro Adachi, Kota Yanagizono, Yasuhito Okano, Hitoshi Koizumi, Isao Uemaetomari, Keiji Tabuchi   +5 more
doaj   +1 more source

Bmi1 Loss in the Organ of Corti Results in p16ink4a Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro. [PDF]

PLoS ONE, 2016
The mature mammalian organ of Corti does not regenerate spontaneously after injury, mainly due to the absence of cell proliferation and the depletion of otic progenitors with age.
Mohamed Bassiouni, Aurélie Dos Santos, Hasan X Avci, Hubert Löwenheim, Marcus Müller   +4 more
doaj   +1 more source

Consequences of Location-Dependent Organ of Corti Micro-Mechanics. [PDF]

PLoS ONE, 2015
The cochlea performs frequency analysis and amplification of sounds. The graded stiffness of the basilar membrane along the cochlear length underlies the frequency-location relationship of the mammalian cochlea. The somatic motility of outer hair cell is
Yanju Liu, Sheryl M Gracewski, Jong-Hoon Nam   +2 more
doaj   +1 more source

Cochlear Development; New Tools and Approaches

Frontiers in Cell and Developmental Biology, 2022
The sensory epithelium of the mammalian cochlea, the organ of Corti, is comprised of at least seven unique cell types including two functionally distinct types of mechanosensory hair cells.
Matthew W. Kelley
doaj   +1 more source

mTOR Signaling in BDNF-Treated Guinea Pigs after Ototoxic Deafening

Biomedicines, 2022
The mammalian target of rapamycin (mTOR) signaling plays a critical role in cell homeostasis, growth and survival. Here, we investigated the localization of the main mTOR signaling proteins in the organ of Corti of normal-hearing and deafened guinea pigs,
Annamaria Tisi, Dyan Ramekers, Vincenzo Flati, Huib Versnel, Rita Maccarone   +4 more
doaj   +1 more source