Effects of DAPT and Atoh1 overexpression on hair cell production and hair bundle orientation in cultured Organ of Corti from neonatal rats. [PDF]
PLoS ONE, 2011 BACKGROUND: In mammals, hair cells do not undergo spontaneous regeneration when they are damaged and result in permanent hearing loss. Previous studies in cultured Organ of Corti dissected from neonatal animals have shown that both DAPT (r-secretase ...
Li-Dong Zhao +11 more
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Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival. [PDF]
PLoS ONE, 2012 In the mammalian inner ear neurosensory cell fate depends on three closely related transcription factors, Atoh1 for hair cells and Neurog1 and Neurod1 for neurons.
Israt Jahan +8 more
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Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner. [PDF]
PLoS Genetics, 2019 The mouse organ of Corti, housed inside the cochlea, contains hair cells and supporting cells that transduce sound into electrical signals. These cells develop in two main steps: progenitor specification followed by differentiation.
Lu M Yang +3 more
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Cochlea cell-specific marker expression upon in vitro Hes1 knockdown [PDF]
Brazilian Journal of Medical and Biological Research, 2021 NOTCH pathway proteins, including the transcriptional factor HES1, play crucial roles in the development of the inner ear by means of the lateral inhibition mechanism, in which supporting cells have their phenotype preserved while they are prevented from
A.C. Batissoco +9 more
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Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation
Redox Report, 2023 Cisplatin-induced ototoxicity is caused by reactive oxygen species. It has been recognized that estradiol (E2) regulates redox balance. However, little is known about the protective mechanisms of E2 against cisplatin-induced ototoxicity.
Masahiro Adachi +5 more
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Bmi1 Loss in the Organ of Corti Results in p16ink4a Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro. [PDF]
PLoS ONE, 2016 The mature mammalian organ of Corti does not regenerate spontaneously after injury, mainly due to the absence of cell proliferation and the depletion of otic progenitors with age.
Mohamed Bassiouni +4 more
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Consequences of Location-Dependent Organ of Corti Micro-Mechanics. [PDF]
PLoS ONE, 2015 The cochlea performs frequency analysis and amplification of sounds. The graded stiffness of the basilar membrane along the cochlear length underlies the frequency-location relationship of the mammalian cochlea. The somatic motility of outer hair cell is
Yanju Liu +2 more
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Cochlear Development; New Tools and Approaches
Frontiers in Cell and Developmental Biology, 2022 The sensory epithelium of the mammalian cochlea, the organ of Corti, is comprised of at least seven unique cell types including two functionally distinct types of mechanosensory hair cells.
Matthew W. Kelley
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mTOR Signaling in BDNF-Treated Guinea Pigs after Ototoxic Deafening
Biomedicines, 2022 The mammalian target of rapamycin (mTOR) signaling plays a critical role in cell homeostasis, growth and survival. Here, we investigated the localization of the main mTOR signaling proteins in the organ of Corti of normal-hearing and deafened guinea pigs,
Annamaria Tisi +4 more
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Organ of Corti: A Listening Device [PDF]
Leonardo Music Journal, 2012 The author discusses a piece that recycles noise in the surrounding environment, inviting active listening and contemplation on the act of listening itself.
David Prior
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