Significance of the Microfluidic Flow Inside the Organ of Corti. [PDF]
J Biomech Eng, 2020 We study the vibration modes of a short section in the middle turn of the gerbil cochlea including both longitudinal and radial interstitial fluid spaces between the pillar cells and hair cells to determine the role of the interstitial fluid flow within ...
Zagadou BF, Barbone PE, Mountain DC.
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Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance While Yap/Tead signaling is well known to influence tissue growth and organ size during development, the molecular outputs of the pathway are tissue- and context-dependent and remain poorly understood.
Gnedeva K +12 more
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eLife, 2016 The signals that induce the organ of Corti and define its boundaries in the cochlea are poorly understood. We show that two Notch modifiers, Lfng and Mfng, are transiently expressed precisely at the neural boundary of the organ of Corti.
Martin L Basch +13 more
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Distribution of ciliary adaptor proteins tubby and TULP3 in the organ of Corti [PDF]
Frontiers in Neuroscience, 2023 Tubby-like proteins are membrane-associated adaptors that mediate directional trafficking into primary cilia. In inner ear sensory epithelia, cilia—including the hair cell’s kinocilium—play important roles as organizers of polarity, tissue architecture ...
Laura A. Lindner +3 more
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Preparation of the intact rodent organ of Corti for RNAscope and immunolabeling, confocal microscopy, and quantitative analysis [PDF]
STAR Protocols, 2021 Summary: This protocol describes the preparation of the mouse organ of Corti for RNAscope, immunolabeling, confocal microscopy, and quantitative image analysis to examine transcript and protein localization, sensory hair cells, and synapses.
Daniel O.J. Reijntjes +3 more
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A glucocorticoid-regulating molecule, Fkbp5, may interact with mitogen-activated protein kinase signaling in the organ of Corti of mice cochleae [PDF]
Scientific ReportsFKBP5 is a 51-Da FK506-binding protein and member of the immunophilin family involved in controlling the signaling of glucocorticoid receptor from the cytosol to nucleus.
Asuka Sato +3 more
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Quantitative High-Resolution Cellular Map of the Organ of Corti
Cell Reports, 2015 The organ of Corti harbors highly specialized sensory hair cells and surrounding supporting cells that are essential for the sense of hearing. Here, we report a single cell gene expression data analysis and visualization strategy that allows for the ...
Jörg Waldhaus +2 more
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Cochlear amplification and tuning depend on the cellular arrangement within the organ of Corti [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance While the near-crystalline structure of the organ-of-Corti cytoarchitecture in the mammalian cochlea has been known for some time, its functional consequences on hearing remain to be established.
Hamid Motallebzadeh +2 more
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Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells. [PDF]
PLoS ONE, 2016 The organ of Corti has evolved a panoply of cells with extraordinary morphological specializations to harness, direct, and transduce mechanical energy into electrical signals.
Lana M Pollock +4 more
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Sound Induced Vibrations Deform the Organ of Corti Complex in the Low-Frequency Apical Region of the Gerbil Cochlea for Normal Hearing : Sound Induced Vibrations Deform the Organ of Corti Complex. [PDF]
J Assoc Res Otolaryngol, 2022 Meenderink SWF, Lin X, Park BH, Dong W.
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