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Molecular profile of cochlear immunity in the resident cells of the organ of Corti [PDF]
BackgroundThe cochlea is the sensory organ of hearing. In the cochlea, the organ of Corti houses sensory cells that are susceptible to pathological insults. While the organ of Corti lacks immune cells, it does have the capacity for immune activity.
Qunfeng Cai+7 more
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Immunoglobulin-like domain containing receptor 1 (ILDR1) is a poorly characterized gene that was first identified in lymphoma cells. Mutations in ILDR1 are responsible for DFNB42, but the pathogenesis of hearing loss caused by ILDR1 mutations remains to ...
Qing Sang+9 more
doaj +2 more sources
Identification of mouse cochlear progenitors that develop hair and supporting cells in the organ of Corti [PDF]
The adult mammalian cochlear sensory epithelium houses two major types of cells, mechanosensory hair cells and underlying supporting cells, and lacks regenerative capacity.
Jin Xu+5 more
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Organ of Corti: A Listening Device [PDF]
The author discusses a piece that recycles noise in the surrounding environment, inviting active listening and contemplation on the act of listening itself.
David Prior
openaire +3 more sources
Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo. [PDF]
Dewey JB+4 more
europepmc +2 more sources
Expression of Neurog1 Instead of Atoh1 Can Partially Rescue Organ of Corti Cell Survival
In the mammalian inner ear neurosensory cell fate depends on three closely related transcription factors, Atoh1 for hair cells and Neurog1 and Neurod1 for neurons.
Israt Jahan+8 more
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The mouse organ of Corti, housed inside the cochlea, contains hair cells and supporting cells that transduce sound into electrical signals. These cells develop in two main steps: progenitor specification followed by differentiation.
Lu M Yang+3 more
doaj +3 more sources
Two-Dimensional Cochlear Micromechanics Measured In Vivo Demonstrate Radial Tuning within the Mouse Organ of Corti [PDF]
H. Y. Lee+7 more
openalex +2 more sources
Cochlea cell-specific marker expression upon in vitro Hes1 knockdown [PDF]
NOTCH pathway proteins, including the transcriptional factor HES1, play crucial roles in the development of the inner ear by means of the lateral inhibition mechanism, in which supporting cells have their phenotype preserved while they are prevented from
A.C. Batissoco+9 more
doaj +1 more source
Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation
Cisplatin-induced ototoxicity is caused by reactive oxygen species. It has been recognized that estradiol (E2) regulates redox balance. However, little is known about the protective mechanisms of E2 against cisplatin-induced ototoxicity.
Masahiro Adachi+5 more
doaj +1 more source