Results 11 to 20 of about 1,992,155 (390)

Isochoric Supercooling Organ Preservation System [PDF]

Bioengineering, 2023
This technical paper introduces a novel organ preservation system based on isochoric (constant volume) supercooling. The system is designed to enhance the stability of the metastable supercooling state, offering potential long-term preservation of large ...
Gabriel Năstase, Florin Botea, George-Andrei Beșchea, Ștefan-Ioan Câmpean, Alexandru Barcu, Ion Neacșu, Vlad Herlea, Irinel Popescu, Tammy T. Chang, Boris Rubinsky, Alexandru Șerban   +10 more
doaj   +3 more sources

Current practice and novel approaches in organ preservation [PDF]

Frontiers in Transplantation, 2023
Organ transplantation remains the only treatment option for patients with end-stage organ failure. The last decade has seen a flurry of activity in improving organ preservation technologies, which promise to increase utilization in a dramatic fashion ...
Ozge Sila Ozgur, Ozge Sila Ozgur, Bat-Erdene Namsrai, Timothy L. Pruett, John C. Bischof, Mehmet Toner, Mehmet Toner, Erik B. Finger, Korkut Uygun, Korkut Uygun   +9 more
doaj   +3 more sources

International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer [PDF]

Nature Reviews Clinical Oncology, 2021
Multimodal treatment strategies for patients with rectal cancer are increasingly including the possibility of organ preservation, through nonoperative management or local excision.
E. Fokas, A. Appelt, R. Glynne-Jones, G. Beets, R. Perez, J. García-Aguilar, E. Rullier, J. Smith, C. Marijnen, F. Peters, M. van der Valk, R. Beets-Tan, A. Myint, J. Gérard, S. Bach, M. Ghadimi, R. Hofheinz, K. Bujko, C. Gani, K. Haustermans, B. Minsky, E. Ludmir, N. West, M. Gambacorta, V. Valentini, M. Buyse, A. Renehan, A. Gilbert, D. Sebag‐Montefiore, C. Rödel   +29 more
semanticscholar   +3 more sources

Practice Patterns for Organ Preservation in US Patients With Rectal Cancer, 2006-2020.

JAMA Oncol, 2023
Importance In March 2023, the National Comprehensive Cancer Network endorsed watch and wait for those with complete clinical response to total neoadjuvant therapy.
A. Loria, M. Tejani, Larissa K.F. Temple, Carla F. Justiniano, Alexa D. Melucci, A. Becerra, J. R. Monson, C. Aquina, F. Fleming   +8 more
semanticscholar   +2 more sources

Successful transplantation of porcine liver grafts following 48-hour normothermic preservation. [PDF]

PLoS ONE, 2017
Current cold storage organ preservation technique fails to preserve marginal donor grafts sufficiently. Evidence from large animal experiments suggests superiority of normothermic machine preservation of liver allografts.
Thomas Vogel, Jens G Brockmann, David Pigott, Desley A H Neil, Anand S Rathnasamy Muthusamy, Constantin C Coussios, Peter J Friend   +6 more
doaj   +11 more sources

Application of Mesenchymal Stem Cells During Machine Perfusion: An Emerging Novel Strategy for Organ Preservation

Frontiers in Immunology, 2021
Although solid organ transplantation remains the definitive management for patients with end-stage organ failure, this ultimate treatment has been limited by the number of acceptable donor organs.
Jiale Li, Qinbao Peng, Ronghua Yang, Kunsheng Li, Peng Zhu, Yufeng Zhu, Pengyu Zhou, Gábor Szabó, Gábor Szabó, Shaoyi Zheng   +9 more
doaj   +2 more sources

Long-Term Results of Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy: The Randomized Phase II OPRA Trial [PDF]

J Clin Oncol, 2023
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available.
F. Verheij, D. Omer, H. Williams, Sabrina T. Lin, L. Qin, J. Buckley, Hannah M Thompson, J. Yuval, Jin K. Kim, R. Dunne, Jorge Marcet, P. Cataldo, B. Polite, Daniel O. Herzig, D. Líška, S. Oommen, Charles M. Friel, C. Ternent, A. Coveler, Steven R. Hunt, A. Gregory, M. Varma, Brian Bello, Joseph C. Carmichael, John C Krauss, A. Gleisner, José G. Guillem, Larissa K.F. Temple, K. Goodman, N. Segal, A. Cercek, R. Yaeger, G. Nash, M. Widmar, I. Wei, E. Pappou, M. Weiser, P. Paty, J. J. Smith, A. Wu, M. Gollub, L. Saltz, J. García-Aguilar   +42 more
semanticscholar   +2 more sources

Organ preservation: current limitations and optimization approaches [PDF]

Frontiers in Medicine
Despite the annual rise in patients with end-stage diseases necessitating organ transplantation, the scarcity of high-quality grafts constrains the further development of transplantation.
Qiulin Ran, Jiayi Zhang, Jisheng Zhong, Ji Lin, Shuai Zhang, Guang Li, Bin You   +6 more
doaj   +2 more sources

Hemoglobin-Based Oxygen Carriers: Potential Applications in Solid Organ Preservation

Frontiers in Pharmacology, 2021
Ameliorating graft injury induced by ischemia and hypoxia, expanding the donor pool, and improving graft quality and recipient prognosis are still goals pursued by the transplant community.
Min Cao, Guoqing Wang, Hongli He, Ruiming Yue, Yong Zhao, Lingai Pan, Weiwei Huang, Yang Guo, Tao Yin, Lina Ma, Dingding Zhang, Xiaobo Huang   +11 more
doaj   +2 more sources

Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. [PDF]

New England Journal of Medicine, 2003
BACKGROUND Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer.
A. Forastiere, H. Goepfert, M. Maor, T. Pajak, R. Weber, W. Morrison, B. Glisson, A. Trotti, J. Ridge, C. Chao, G. Peters, Ding‐Jen Lee, A. Leaf, J. Ensley, J. Cooper   +14 more
semanticscholar   +2 more sources