Results 31 to 40 of about 119,972 (311)

James Southard, PhD, Professor of Surgery (Emeritus), Pioneer in Organ Preservation, Co-inventor, UW Organ Preservation Solution.

open access: yesTransplantation, 2020
JS: I had finished a postdoctoral fellowship at the Enzyme Institute, University of Wisconsin, and was working there in a research position. I knew little about opportunities in organ preservation. Dr Belzer had recently (1974) become Chair of Surgery at
J. Southard
semanticscholar   +1 more source

Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation: A randomized, open-label, clinical trial

open access: yesHepatology, 2023
Background and Aims: In liver transplantation, cold preservation induces ischemia, resulting in significant reperfusion injury. Hypothermic oxygenated machine perfusion (HMP-O2) has shown benefits compared to static cold storage (SCS) by limiting ...
G. Panayotova   +17 more
semanticscholar   +1 more source

Effect of Melatonin on Increasing the Effectiveness of Liver Preservation Solution

open access: yesThe Turkish Journal of Gastroenterology, 2023
Background/Aims: Various tissue preservation solutions are used during the removal of the organ and during transplantation to protect the normal histological and biochemical characteristics of tissue while performing a successful liver transplant. In our
Mehmet Mustafa Erdogan   +5 more
semanticscholar   +1 more source

Comprehensive review of the application of MP and the potential for graft modification

open access: yesFrontiers in Transplantation, 2023
IntroductionFollowing procurement, the liver graft is exposed to an ischemic period that triggers several pathophysiologic changes in response to oxygen deprivation.
Paola A. Vargas   +2 more
doaj   +1 more source

A Potential Route to Reduce Ischemia/Reperfusion Injury in Organ Preservation

open access: yesCells, 2022
The pathophysiological process of ischemia and reperfusion injury (IRI), an inevitable step in organ transplantation, causes important biochemical and structural changes that can result in serious organ damage. IRI is relevant for early graft dysfunction
Marc Micó-Carnero   +5 more
doaj   +1 more source

The Effect of Antioxidant Added to Preservation Solution on the Protection of Kidneys before Transplantation

open access: yesInternational Journal of Molecular Sciences, 2022
Ischemia–reperfusion injury is a key clinical problem of transplantology. Current achievements in optimizing organ rinse solutions and storage techniques have significantly influenced the degree of graft damage and its survival after transplantation.
A. Ostróżka-Cieślik
semanticscholar   +1 more source

Organ Preservation Solutions in Transplantation: A Literature Review

open access: yesExperimental and Clinical Transplantation, 2021
Renal transplant with ABO-incompatible donors expands the donor pool. Earlier studies have focused the use of protocol biopsies in ABOincompatible transplant patients. Our study described outcomes of indication (for cause) renal biopsies and clinical outcomes in patients with ABO-incompatible renal transplant.This retrospective study included 164 ...
Samara Guilhermina, de Sousa   +7 more
openaire   +2 more sources

The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature

open access: yesMolecules, 2020
Transplantation is currently a routine method for treating end-stage organ failure. In recent years, there has been some progress in the development of an optimal composition of organ preservation solutions, improving the vital functions of the organ and
Aneta Ostróżka-Cieślik   +1 more
doaj   +1 more source

Recent Methods of Kidney Storage and Therapeutic Possibilities of Transplant Kidney

open access: yesBiomedicines, 2022
Kidney transplantation is the standard procedure for the treatment of end-stage renal disease (ESRD). During kidney storage and before implantation, the organ is exposed to damaging factors which affect the decline in condition.
Anna Radajewska   +2 more
doaj   +1 more source

Melatonin in preservation solutions prevents ischemic injury in rat kidneys.

open access: yesPLoS ONE, 2022
Transplantation is lifesaving and the most effective treatment for end-stage organ failure. The transplantation success depends on the functional preservation of organs prior to transplantation.
Abdurrahman Coskun   +20 more
doaj   +1 more source

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