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Organ preservation solutions for whole organ pancreas transplantation

Current Opinion in Organ Transplantation, 2011
University of Wisconsin solution is currently the most commonly used solution for abdominal organ transplantation and is the standard to which newer solutions are compared. In recent years, we have witnessed the introduction of two alternative preservation solutions, histidine-tryptophan-ketoglutarate (HTK) solution and Celsior solution, into the ...
Richard S. Mangus   +2 more
openaire   +3 more sources

Abdominal Organ Preservation Solutions in the Age of Machine Perfusion

Transplantation, 2022
The past decade has been the foreground for a radical revolution in the field of preservation in abdominal organ transplantation. Perfusion has increasingly replaced static cold storage as the preferred and even gold standard preservation method for marginal-quality organs.
Pedro, Ramos   +6 more
openaire   +2 more sources

Organ-Specific Solutions and Strategies for the Intestinal Preservation

International Reviews of Immunology, 2013
Among the intraabdominal organs, the intestine is the most susceptible to storage injury and as a consequence its safe cold ischemic time in the clinic is restricted to below 10 hours. The current practice for the intestinal preservation (IP) consists of an in-situ vascular flush with iced University of Wisconsin or Histidine-Tryptophan-Ketoglutarate ...
Mihai Oltean, Thomas A. Churchill
openaire   +3 more sources

CLINICAL ORGAN PRESERVATION WITH UW SOLUTION

Transplantation, 1989
La conservation du foie et du pancreas fait appel a la solution U.W. (University of Niconsin) et a la solution Euro Collins, mais souvent une des variantes. En raison des echanges croissants des organes entre les centres on preconise de reserver le terme «conservation par la solution U.W.» uniquement lorsque la methode originelle est suivie et d ...
openaire   +3 more sources

Directional Freezing: A Solution to the Methodological Challenges to Preserve Large Organs [PDF]

open access: possibleSeminars in Reproductive Medicine, 2009
Although 60 years have passed since the first successful freezing of cells, whole organ freezing is in its initial phase. Heat and mass transfer has limited the success of large tissue and organ cryopreservation either by slow freezing or vitrification. In this article we discuss the limiting factors for the successful freezing of whole organs, such as
Yehudit Natan, Amir Arav
openaire   +2 more sources

Newly approved organ preservation solution puts longer life in liver grafts.

Journal of the American Medical Association (JAMA), 1989
AN ORGAN preservation medium, recently approved by the Food and Drug Administration for clinical use in the United States, is making liver transplantation a more leisurely procedure, according to several reports at the recent meeting of the American ...
B. Merz
semanticscholar   +1 more source

Organ preservation solutions impair deformability of erythrocytes in vitro

Transplantation Proceedings, 2003
Microcirculatory disturbances are observed frequently after restoration of the circulation in transplanted organ. The exact mechanisms responsible for impaired microcirculation during reperfusion are unknown. Erythrocyte deformability is an important factor maintaining the microcirculation.
B. Chmiel, L. Cierpka
openaire   +3 more sources

Inherent toxicity of organ preservation solutions to cultured hepatocytes

Cryobiology, 2008
Organ preservation solutions have been designed to protect grafts against the injury inflicted by cold ischemia. However, toxicity of University of Wisconsin (UW) solution during rewarming has been reported. Therefore, we here assessed the toxicity of UW, histidine-tryptophan-ketoglutarate (HTK), Euro-Collins, histidine-lactobionate (HL), sodium ...
Ursula Rauen, Herbert de Groot
openaire   +3 more sources

Endothelial cell toxicity of solid-organ preservation solutions

The Annals of Thoracic Surgery, 1990
Endothelial cell damage caused by myocardial cardioplegic solutions (Bretschneider HTK and St. Thomas' Hospital No. 2) or renal and hepatic cold storage solutions (modified Collins and University of Wisconsin solution) was assessed in monolayer cultures of adult human venous endothelial cells at 4 degrees to 10 degrees C with phase-contrast microscopy.
Peter Zilla   +5 more
openaire   +3 more sources

New Solution for Organ Preservation

1990
Two methods are used to preserve organs for clinical transplantation: simple cold storage (CS) and continuous machine perfusion (MP). Simple cold storage uses a flushing solution to replace the blood in the organ and to cool the organ to about 4°C.
openaire   +2 more sources

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