Results 11 to 20 of about 488,871 (169)

A Potential Route to Reduce Ischemia/Reperfusion Injury in Organ Preservation [PDF]

Cells, 2022
The pathophysiological process of ischemia and reperfusion injury (IRI), an inevitable step in organ transplantation, causes important biochemical and structural changes that can result in serious organ damage. IRI is relevant for early graft dysfunction
Marc Micó-Carnero, Mohamed Amine Zaouali, Carlos Rojano-Alfonso, Cristina Maroto-Serrat, Hassen Ben Abdennebi, Carmen Peralta   +5 more
doaj   +2 more sources

Hyperbranched polyglycerol as a colloid in cold organ preservation solutions. [PDF]

PLoS ONE, 2015
Hydroxyethyl starch (HES) is a common colloid in organ preservation solutions, such as in University of Wisconsin (UW) solution, for preventing graft interstitial edema and cell swelling during cold preservation of donor organs.
Sihai Gao, Qiunong Guan, Irina Chafeeva, Donald E Brooks, Christopher Y C Nguan, Jayachandran N Kizhakkedathu, Caigan Du   +6 more
doaj   +2 more sources

Development of a Novel Perfusable Solution for ex vivo Preservation: Towards Photosynthetic Oxygenation for Organ Transplantation [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
Oxygen is the key molecule for aerobic metabolism, but no animal cells can produce it, creating an extreme dependency on external supply. In contrast, microalgae are photosynthetic microorganisms, therefore, they are able to produce oxygen as plant cells
Valentina Veloso-Giménez, Rosalba Escamilla, Rosalba Escamilla, David Necuñir, Rocío Corrales-Orovio, Rocío Corrales-Orovio, Sergio Riveros, Carlo Marino, Carolina Ehrenfeld, Carolina Ehrenfeld, Christian Dani Guzmán, Mauricio P. Boric, Rolando Rebolledo, Rolando Rebolledo, José Tomás Egaña   +14 more
doaj   +3 more sources

The novel compound PICCS improves cell viability during cold storage and reduces pulmonary ischemia-reperfusion injury in a rat model [PDF]

Scientific Reports
A simple method to achieve better organ preservation is the addition of compounds to the preservation solution, which effectively inhibits cold injury.
Yuhei Yokoyama, Masayasu Toyomoto, Nobuo Tanaka, Satona Tanaka, Shigeto Nishikawa, Hidenao Kayawake, Yuki Morimura, Hiromi Oda, Momono Yamauchi, Makoto Yamamoto, Toyofumi F. Chen-Yoshikawa, Masatoshi Hagiwara, Hiroshi Date   +12 more
doaj   +2 more sources

Activation of Nrf2 pathway by 4-Octyl itaconate enhances donor lung function in cold preservation settings [PDF]

Respiratory Research
Background Lung transplantation is the primary treatment for end-stage lung diseases. However, ischemia-reperfusion injury (IRI) significantly impacts transplant outcomes. 4-Octyl itaconate (4-OI) has shown potential in mitigating organ IRI, although its
Xinliang Gao, Mingbo Tang, Jialin Li, Jianzun Ma, Zhengrui Liu, Wei Liu   +5 more
doaj   +2 more sources

Role of PEG35, Mitochondrial ALDH2, and Glutathione in Cold Fatty Liver Graft Preservation: An IGL-2 Approach. [PDF]

, 2021
The total damage inflicted on the liver before transplantation is associated with severalsurgical manipulations, such as organ recovery, washout of the graft, cold conservation in organpreservation solutions (UW, Celsior, HTK, IGL-1), and rinsing of the ...
Adam, R. (René), Bardallo, Raquel G., Carbonell i Camós, Teresa, da Silva, Rui T., Folch i Puy, Emma, Palmeira, Carlos, Panisello-Roselló, Arnau, Pirenne, Jacques, Roselló Catafau, Juan   +8 more
core   +2 more sources

Prospects for fertility preservation: the ovarian organ function reconstruction techniques for oogenesis, growth and maturation in vitro

Frontiers in Physiology, 2023
Today, fertility preservation is receiving more attention than ever. Cryopreservation, which preserves ovarian tissue to preserve fertility in young women and reduce the risk of infertility, is currently the most widely practiced.
Bai Hu, Bai Hu, Renjie Wang, Renjie Wang, Di Wu, Di Wu, Rui Long, Rui Long, Jinghan Ruan, Jinghan Ruan, Lei Jin, Ding Ma, Ding Ma, Chaoyang Sun, Chaoyang Sun, Shujie Liao, Shujie Liao   +16 more
doaj   +1 more source

The influence of perfusion solution on renal graft viability assessment [PDF]

, 2012
BACKGROUND: Kidneys from donors after cardiac or circulatory death are exposed to extended periods of both warm ischemia and intra-arterial cooling before organ recovery.
CH Wilson, CH Wilson, D Shoskes, G Kootstra, JH Lee, JV Bonventre, JW Daemen, KJ Livak, MA Gok, MA Gok, MA Gok, MD Kay, MH Booster, MM El-Mas, MT Gravel, N Ahmad, N Ahmad, NR Brook, P Bell, RA Cowley, RT Currin, S Balupuri, SF Bronk, SR Johnson, TJ Wheatley, Y Lin, ZA Stewart   +26 more
core   +1 more source

Hemoglobin-Based Oxygen Carriers: Potential Applications in Solid Organ Preservation

Frontiers in Pharmacology, 2021
Ameliorating graft injury induced by ischemia and hypoxia, expanding the donor pool, and improving graft quality and recipient prognosis are still goals pursued by the transplant community.
Min Cao, Guoqing Wang, Hongli He, Ruiming Yue, Yong Zhao, Lingai Pan, Weiwei Huang, Yang Guo, Tao Yin, Lina Ma, Dingding Zhang, Xiaobo Huang   +11 more
doaj   +1 more source

The relevance of the UPS in the fatty liver graft preservation: a new approach for IGL-1 and HTK solutions [PDF]

, 2017
The 26S proteasome is the central proteolytic machinery of the ubiquitin proteasome system (UPS), which is involved in the degradation of ubiquitinated protein substrates.
Adam, R. (René), Alva Bocanegra, Norma V. (Norma Violeta), Amine Zaouali, Mohamed, Carbonell i Camós, Teresa, Flores, Marta, Folch i Puy, Emma, Hotter Corripio, Georgina, Lopez, Alexandre, Panisello Roselló, Arnau, Roselló Catafau, Juan, Verde, Eva   +10 more
core   +2 more sources