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Organelle biogenesis in the endoplasmic reticulum
Nature Cell Biology, 2017Understanding organelle biogenesis is a central focus of cell biology. Whereas some are generated from existing organelles, others can be generated de novo. Most de novo organelle biogenesis occurs in the endoplasmic reticulum (ER). Here, we review the role of the ER in the generation of peroxisomes, lipid droplets, and omegasomes, which are platforms ...
William A Prinz, Amit S Joshi
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Membrane fusion in organelle biogenesis
Intracellular membrane fusion is a fascinating reaction that is crucial for cellular function. Several components of the membrane fusion machinery have been identified, although a precise understanding of the fusion mechanism is lacking. More recent studies are revealing novel proteins that regulate membrane fusion during organelle assembly.
Denesvre, Caroline, Malhotra, Vivek
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Temporal regulation of organelle biogenesis
Physical Biology, 2022Abstract Organelle abundance in cells is tightly regulated in response to external stimuli, but the underlying mechanisms remain poorly understood. Time-lapse imaging of fluorescently labelled organelles enables single-cell measurements of organelle copy numbers, revealing the time evolution of their distribution across a cell population.
Aniruddha Nagarajan +2 more
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Functions of Rab GTPases in organelle biogenesis
Topics in Current Genetics, 2004Ruth N Collins
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Biogenesis of rhoptry organelles in Plasmodium falciparum
Molecular and Biochemical Parasitology, 1993Biogenesis of the rhoptry organelle of Plasmodium falciparum was studied by examining the synthesis and assembly of rhoptry proteins at different stages of intraerythrocytic development. Rhoptry proteins examined in this study were those of the high molecular weight complex of 140/130/110 kDa and referred to as Rhop-H1,2,3 and the low molecular weight ...
N S, Jaikaria +3 more
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Hospital Practice, 1974
How are intracellular structures formed, maintained, replaced? These processes, at the very heart of life, appear to be governed by the principle of self-assembly, namely, that the macromolecules of which organelles are composed contain within themselves the “information” that leads to their association and interaction with one another.
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How are intracellular structures formed, maintained, replaced? These processes, at the very heart of life, appear to be governed by the principle of self-assembly, namely, that the macromolecules of which organelles are composed contain within themselves the “information” that leads to their association and interaction with one another.
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Theory of Organelle Biogenesis
2007Organelles, defined as intracellular membrane-bound structures in eukaryotic cells, were described from the early days of light microscopy and the development of cell theory in the 19th century. During the 20th century, electron microscopy and subcellular fractionation enabled the discovery of additional organelles and, together with radiolabel-ling ...
Barbara M. Mullock, J. Paul Luzio
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