Results 231 to 240 of about 196,311 (276)

The (European) protein homeostasis network. [PDF]

FEBS J
Chevet E.
europepmc   +1 more source

LGR6 couples maresin 1 signaling to glycolytic flux and protein lactylation for the rescue of diabetic cardiomyopathy

Journal of Diabetes Investigation, EarlyView.
MaR1 activates LGR6‐AMPK signaling to restore metabolic flexibility in diabetic hearts. Glycolytic recovery replenishes intracellular lactate to rescue protective protein lysine lactylation, which reactivates PINK1/Parkin‐mediated mitophagy to eliminate damaged mitochondria.
Bin Feng, Chao Chen, Lin Chen, Yuqiong Chen, Wenjun Mao, Peiran Yu, Hao Yu, Bimin Shi, Nannan Zhang   +8 more
wiley   +1 more source

Natural Small Molecules Targeting Mitochondrial Quality Control for the Treatment of Metabolic Diseases: Mechanisms, Novel Formulations, and Translational Perspectives. [PDF]

Pharmaceuticals (Basel)
Zhao C, Gao Y, Zhou T, Sun L, Qu Q.
europepmc   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Multiscale interactions in cardiovascular homeostasis and remodeling: from molecular coupling to organelle and multicellular networks. [PDF]

J Physiol Sci
Nishida M.
europepmc   +1 more source

Mitohormesis linking metabolic dysfunction and neurodegeneration: implications for dementia and therapeutic strategies. [PDF]

Front Mol Neurosci
Otoda T, Nakajima H, Takayama T.
europepmc   +1 more source

Lipid droplet-mitochondria contact sites as druggable spatial-pharmacology targets in respiratory disease: cross-cell-type mechanisms and translational strategies. [PDF]

Front Cell Dev Biol
Li S, Bai R.
europepmc   +1 more source

Acyl carrier protein is essential for apicoplast biogenesis in malaria parasites independent of fatty acid synthesis. [PDF]

Elife
Geher SWR, Falekun S, Pita-Aquino JN, Swift RP, Okada M, Jami-Alahmadi Y, Wohlschlegel JA, Prigge ST, Sigala PA.   +8 more
europepmc   +1 more source