Results 211 to 220 of about 196,311 (276)

Introduction to Genetic Engineering. XII. Biogenesis of organelles

RADIOISOTOPES, 1988
openaire   +3 more sources

A novel regulatory mechanism of AQP2 trafficking to explain the syndrome of inappropriate antidiuresis . In: Meeting of Membrane Trafficking and Organelle Biogenesis.

, 2012
RANIERI, MARIANNA, DEVUYST O, DEEN PMT, LASORSA D, DE MISE A, MOLA MG, TAMMA, GRAZIA, VALENTI, Giovanna, TRIMPERT C, MASTROFRANCESCO L, SVELTO, Maria   +10 more
core  

Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism

The FEBS Journal, EarlyView.
AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney, James Griffin, Nouf Khan, Balnur Ibrash, Matthew J. O'Connor, Tomas Venit, Elizabeth Mayela Ambrosio, Spiros A. Pergantis, Elke Ober, Piergiorgio Percipalle, Kirsten C. Sadler   +10 more
wiley   +1 more source

More than the 'master regulator of cytosolic proteostasis': new roles for HSF1 in promoting tissue health. [PDF]

Philos Trans R Soc Lond B Biol Sci
Labbadia J.
europepmc   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Positive-Sense RNA Viruses Reprogramming Membrane Contact Sites to Remodel Organelles and Control Cell Fate. [PDF]

Viruses
Zhang D, Wang L, Zhang X, Yang F, Zhang J, Chen W.   +5 more
europepmc   +1 more source

The epigenetic landscape of skeletal muscle in response to exercise and aging

The FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source

AMPK-Orchestrated Metabolic Reprogramming in Some Flavivirus Infections: Mechanisms and Therapeutic Opportunities. [PDF]

Viruses
Craft K, Muhammad I, Pei S, Tang Q.
europepmc   +1 more source

TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics

The FEBS Journal, EarlyView.
This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga, Zsolt Ráduly, Beáta Boros‐Oláh, Éva Nagy, Zsolt Karányi, László Halász, Bálint László Bálint, György Vámosi, Emese Tóth, Péter Bai, Serena Santangelo, Patrizia Bossolasco, Antonia Ratti, Vincent Géli, Yves Pommier, Lóránt Székvölgyi   +15 more
wiley   +1 more source

A live‐cell autophagy reporter reveals reversible vacuolation in naked mole‐rat skin fibroblasts under lysosomal stress

The FEBS Journal, EarlyView.
A tandem fluorescent mCherry–EGFP–LC3 reporter enables live‐cell visualisation of autophagy–lysosome dynamics in naked mole‐rat skin fibroblasts. Chloroquine‐induced lysosomal stress promotes accumulation of neutral LC3‐positive compartments and triggers pronounced LC3‐associated vacuolation.
Fangze Tong, Mateo P. Hoare, Laura J. Grundy, Filomena Gallo, Karin H. Müller, Ewan St. John Smith, Janet R. Kumita   +6 more
wiley   +1 more source