Results 41 to 50 of about 340,460 (357)
NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress
Nature Communications, 2019 Transport of dietary cholesterol from endocytic organelles to the endoplasmic reticulum (ER) is essential for cholesterol homoeostasis, but the mechanism and regulation of this transport remains poorly defined.
Doris Höglinger +10 more
semanticscholar +1 more source
Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum
Frontiers in Cellular Neuroscience, 2019 The target for the “rapid” (<24 h) antidepressant effects of S-ketamine is unknown, vitiating programs to rationally develop more effective rapid antidepressants.
Kallol Bera +19 more
doaj +1 more source
A Toolbox for Organelle Mechanobiology Research—Current Needs and Challenges
Micromachines, 2019 Mechanobiology studies from the last decades have brought significant insights into many domains of biological research, from development to cellular signaling.
Qian Feng +2 more
doaj +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
eLife, 2015 Mitochondrial division, essential for survival in mammals, is enhanced by an inter-organellar process involving ER tubules encircling and constricting mitochondria.
Uri Manor +7 more
doaj +1 more source
Circadian Organelles: Rhythms at All Scales
Cells, 2021 Circadian clocks have evolved in most light-sensitive organisms, from unicellular organisms to mammals. Consequently, a myriad of biological functions exhibits circadian rhythmicity, from behavior to physiology, through tissue and cellular functions to ...
Rona Aviram, Yaarit Adamovich, Gad Asher
doaj +1 more source
Regulation of Organelle Biogenesis [PDF]
Cell, 1996 We are grateful to the members of the Walter laboratory and of the many other laboratories whose work is reviewed for their helpful discussions, for their critical reading of this manuscript, and for making preprints available prior to publication. Because of space limitations, we were not able to include many of the primary references, and the readers
Jodi Nunnari, Peter Walter
openaire +3 more sources
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Mechanisms of organelle biogenesis govern stochastic fluctuations in organelle abundance
eLife, 2014 Fluctuations in organelle abundance can profoundly limit the precision of cell biological processes from secretion to metabolism. We modeled the dynamics of organelle biogenesis and predicted that organelle abundance fluctuations depend strongly on the ...
Shankar Mukherji, Erin K O'Shea
doaj +1 more source