Results 251 to 260 of about 114,242,522 (291)

Human Organic Anion Transporter 2 Is Distinct From Organic Anion Transporters 1 and 3 With Respect to Transport Function [PDF]

American Journal of Physiology - Renal Physiology, 2015
Phylogentically, organic anion transporter (OAT)1 and OAT3 are closely related, whereas OAT2 is more distant. Experiments with human embryonic kidney-293 cells stably transfected with human OAT1, OAT2, or OAT3 were performed to compare selected transport properties. Common to OAT1, OAT2, and OAT3 is their ability to transport cGMP. OAT2 interacted with
Yohannes Hagos, Gerhard Burckhardt, Birgitta C Burckhardt   +2 more
exaly   +5 more sources

Identification of Organic Anion Transporting Polypeptide 4 (Oatp4) as a Major Full-Length Isoform of the Liver-Specific Transporter-1 (Rlst-1) in Rat Liver

FEBS Letters, 2000
A novel organic anion transporting polypeptide (Oatp)4(1) was isolated from rat liver that is 35 amino acids longer than the reported rat liver specific organic anion transporter (rlst)-1 and exhibits a 64% amino acid sequence identity with the human ...
Valentino Cattori, Bruno Hagenbuch, Bruno Stieger   +2 more
exaly   +2 more sources

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Transport of Ochratoxin A by Renal Multispecific Organic Anion Transporter 1

The Journal of Pharmacology and Experimental Therapeutics, 1999
In the present study, we investigated the transport of ochratoxin A (OTA) by kidney-specific organic anion transporter 1 (OAT1). When expressed in Xenopus laevis oocytes, OAT1 mediated sodium-independent uptake of OTA (Km = 2.1 microM). Piroxicam, which has been shown to prevent the nephrotoxicity of OTA, inhibited OAT1-mediated uptake of OTA.
M, Tsuda, T, Sekine, M, Takeda, S H, Cha, Y, Kanai, M, Kimura, H, Endou   +6 more
openaire   +2 more sources

Impact of the induced organic anion transporter 1 (Oat1) renal expression by furosemide on the pharmacokinetics of organic anions

Nephrology, 2017
AbstractAimFurosemide is a loop diuretic. Different authors demonstrated that continuous administration of furosemide modulates the expression of organic anion transporters. This study was undertaken to simultaneously evaluate the effects of furosemide pretreatment on organic anion transporter 1 (Oat1) and multidrug resistance protein 2 (Mrp2) renal ...
Severin, María Julia, Hazelhoff, Maria Herminia, Bulacio, Romina Paula, Mamprin, María Eugenia, Brandoni, Anabel, Torres, Adriana Monica   +5 more
openaire   +3 more sources

Inhibition of the human organic anion transporter 1 by the caffeine metabolite 1-methylxanthine

Biochemical and Biophysical Research Communications, 2004
Caffeine (1,3,7-trimethylxanthine) is daily and widely consumed in beverages and food and is mainly metabolized to 1,7-dimethylxanthine and 1-methylxanthine. Indirect clinical evidence suggests that 1-methylxanthine interacts with the organic anion transport system in the human kidney.
Jens, Rengelshausen, Heike, Lindenmaier, Tomas, Cihlar, Ingeborg, Walter-Sack, Walter Emil, Haefeli, Johanna, Weiss   +5 more
openaire   +2 more sources

Organic anion transporting polypeptides and organic cation transporter 1 contribute to the cellular uptake of the flavonoid quercetin

Naunyn-Schmiedeberg's Archives of Pharmacology, 2014
Flavonoids such as quercetin and kaempferol mediate several health protective effects, e.g., anticancer effects. They are inhibitors of organic anion transporting polypeptides (OATP) and organic cation transporters (e.g., OCT2). However, little is known whether such transporters contribute to the cellular uptake of flavonoids.
Hartmut, Glaeser, Krystyna, Bujok, Ingrid, Schmidt, Martin F, Fromm, Kathrin, Mandery   +4 more
openaire   +2 more sources

Compensation Increase in Organic Anion Excretion in Rats with Acute Biliary Obstruction: Role of the Renal Organic Anion Transporter 1

Pharmacology, 2003
The purpose of the present study was to examine in rats the effects of acute bile duct ligation on the expression of the organic anion transporter 1 in the kidney and the consequences of these effects on the systemic clearance of organic anions, particularly on <i>p</i>-aminohippurate (PAH) clearance, since it has been viewed as the ...
Anabel, Brandoni, Nora B, Quaglia, Adriana M, Torres   +2 more
openaire   +2 more sources

Interactions of human organic anion transporters 1–4 and human organic cation transporters 1–3 with the stimulant drug methamphetamine and amphetamine

Legal Medicine, 2020
Drug membrane transport system proteins, namely, drug transporters, are expressed in the kidney and liver and play a crucial role in the excretion process. This study aimed to elucidate the interactions of the drug transporters human organic anion transporters 1, 2, 3, 4 (hOAT1, 2, 3, 4) and human organic cation transporters 1, 2, 3 (hOCT1, 2, 3 ...
Shoetsu, Chiba, Ayako, Ro, Toru, Ikawa, Yukino, Oide, Toshiji, Mukai   +4 more
openaire   +2 more sources

Organic Anion Transporter 1 Is Inhibited by Multiple Mechanisms and Shows a Transport Mode Independent of Exchange

Drug Metabolism and Disposition, 2015
The mechanism by which drugs inhibit organic anion transporter 1 (OAT1) was examined. OAT1 was stably expressed in Chinese hamster ovary (CHO) cells, and para-aminohippurate (PAH) and 6-carboxyfluorescein were the substrates. Most compounds (10 of 14) inhibited competitively, increasing the Michaelis constant (Km) without affecting the maximal ...
Adam G, Hotchkiss, Tiandai, Gao, Usman, Khan, Liam, Berrigan, Mansong, Li, Leslie, Ingraham, Ryan M, Pelis   +6 more
openaire   +2 more sources