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Organic anion transporter 1 (OAT1) involved in renal cell transport of aristolochic acid I
Human & Experimental Toxicology, 2011Aristolochic acids (AAs) are a family of structurally related nitrophenanthrene carboxylic acids that are present in medicinal herbs such as Aristolochia species. The organic anion transporters (OATs) of the solute carrier ( SLC22) gene family located in the renal proximal tubules play a key role in the excretion of a variety of exogenous and ...
Y, Zeng +6 more
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Chemico-Biological Interactions
Niclosamide is an anthelmintic drug with a long history of use and is generally safe and well tolerated in humans. As the conventional dose of niclosamide results in a low but certain level in systemic circulation, drug interactions with concomitant drugs should be considered.
Min-Ji Kang +5 more
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Niclosamide is an anthelmintic drug with a long history of use and is generally safe and well tolerated in humans. As the conventional dose of niclosamide results in a low but certain level in systemic circulation, drug interactions with concomitant drugs should be considered.
Min-Ji Kang +5 more
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2022
Organic anion transporter 1 (SLC22A6/OAT1) plays a key role in renal tubular excretion of endo- and exogenous anionic substances including drugs. Since the inhibition of OAT1 function by a concomitant drug may cause pharmacokinetic drug-drug interactions (DDIs) in clinical practice, an in vitro uptake study to evaluate the inhibition potency of OAT1 is
Katsuhisa, Inoue +2 more
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Organic anion transporter 1 (SLC22A6/OAT1) plays a key role in renal tubular excretion of endo- and exogenous anionic substances including drugs. Since the inhibition of OAT1 function by a concomitant drug may cause pharmacokinetic drug-drug interactions (DDIs) in clinical practice, an in vitro uptake study to evaluate the inhibition potency of OAT1 is
Katsuhisa, Inoue +2 more
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Technetium‐99m‐MAG3 as a transport substrate of rat renal organic anion transporter‐1
Journal of Labelled Compounds and Radiopharmaceuticals, 2001AbstractThe first step of technetium‐99m‐mercaptoacetylglycylglycylglycine (99mTc‐MAG3) secretion by the proximal tubule cells is the extraction of 99mTc‐MAG3 from the peritubular plasma by proximal tubule cells through the basolateral membrane. The evidence for 99mTc‐MAG3 being excreted from renal proximal tubules via rat organic anion transporter 1 ...
N. Shikano +3 more
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Interaction of zalcitabine with human organic anion transporter 1.
Die Pharmazie, 2006The present study aimed to investigate the interaction of zalcitabine with human organic anion transporter 1 (hOATI) during renal excretion. Contribution of OAT1 to the renal transport of zalcitabine was examined using the transfected cell lines overexpressing the human organic anion transporter1 (CHO/hOAT1 cells).
Ming Ji, Jin, Hyo-Kyung, Han
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Organic anion transporter 1 and 3 contribute to traditional Chinese medicine-induced nephrotoxicity
Chinese Journal of Natural Medicines, 2020With the internationally growing popularity of traditional Chinese medicine (TCM), TCM-induced nephropathy has attracted public attention. Minimizing this toxicity is an important issue for future research. Typical nephrotoxic TCM drugs such as Aristolochic acid, Tripterygium wilfordii Hook.
Qing-Qing, Shen +6 more
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Biochemical and Biophysical Research Communications, 2000
We have cloned a cDNA that codes for mouse liver-specific transporter-1, mouse lst-1. The cDNA is comprised of 3296 base pairs and it contains a coding sequence for a protein of 689 amino acids with 12 putative transmembrane domains. The deduced amino acid sequence of the mouse lst-1 shares 64 and 77% identities with the reported human and rat lsts ...
K, Ogura, S, Choudhuri, C D, Klaassen
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We have cloned a cDNA that codes for mouse liver-specific transporter-1, mouse lst-1. The cDNA is comprised of 3296 base pairs and it contains a coding sequence for a protein of 689 amino acids with 12 putative transmembrane domains. The deduced amino acid sequence of the mouse lst-1 shares 64 and 77% identities with the reported human and rat lsts ...
K, Ogura, S, Choudhuri, C D, Klaassen
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Transport of 99mTc-MAG3 via rat renal organic anion transporter 1.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2004Recently, complementary DNA (cDNA) encoding a p-aminohippurate (PAH) transporter designated rat organic anion transporter 1 (OAT1) was isolated. OAT1, a multispecific organic anion transporter at the basolateral membrane, is exclusively expressed in the middle segment of the proximal tubule in the rat kidney.
Naoto, Shikano +4 more
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Decreased Renal Organic Anion Transporter 3 Expression in Type 1 Diabetic Rats
American Journal of the Medical Sciences, 2014Organic anion transporter 3 (Oat3) plays an essential role in the renal excretion of organic anions. Reduced renal Oat3 expression potentially contributes to an impaired anion clearance and causes abnormal kidney function. This study examined the effects of diabetes on the expression and function of rat renal Oat3.Experimental diabetes was induced by ...
Arjinajarn, Phatchawan +3 more
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Acamprosate is an inhibitor of the renal organic anion transporter (OAT) 1
2019Introduction. Acamprosate is a BCS class III, non-metabolized, anionic drug substance for which the excretion mechanism is not fully understood. Intravenous administration in rats of acamprosate together with probenecid, a known substrate and inhibitor of the organic anion transporter (OAT) 1 (SLC22A6) (1), decreased the renal clearance (ClR) of ...
Antonescu, Irina-Elena +8 more
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