Results 81 to 90 of about 114,242,522 (291)

Decreased expression of breast cancer resistance protein in the duodenum in patients with obstructive cholestasis [PDF]

, 2006
Background/Aims: The expression of transporters involved in bile acid homeostasis is differentially regulated during obstructive cholestasis. Since the drug efflux transporter breast cancer resistance protein (BCRP) is known to transport bile acids, we ...
Beuers, Ulrich, Lehmann, Frank, Terracciano, Luigi, Hruz, Petr, Zimmermann, Christian, Gutmann, Heike, Drewe, Juergen, Beglinger, Christoph, Zimmermann C, Gutmann H, Hruz P, Beuers U, Lehmann F, Terracciano L, Drewe J, Beglinger C   +15 more
core   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Using Ex Vivo Porcine Jejunum to Identify Membrane Transporter Substrates: A Screening Tool for Early—Stage Drug Development

Biomedicines, 2020
Robust, predictive ex vivo/in vitro models to study intestinal drug absorption by passive and active transport mechanisms are scarce. Membrane transporters can significantly impact drug uptake and transporter-mediated drug–drug interactions can play a ...
Yvonne E. Arnold, Yogeshvar N. Kalia
doaj   +1 more source

Co-localization and interaction of organic anion transporter 1 with caveolin-2 in rat kidney [PDF]

Experimental & Molecular Medicine, 2005
The organic anion transporters (OAT) have recently been identified. Although the some transport properties of OATs in the kidney have been verified, the regulatory mechanisms for OAT's functions are still not fully understood. The rat OAT1 (rOAT1) transports a number of negatively charged organic compounds between the cells and their extracellular ...
Jin-Oh, Kwak, Hyun-Woo, Kim, Kwang-Jin, Oh, Dong Su, Kim, Ki Ok, Han, Seok Ho, Cha   +5 more
openaire   +2 more sources

Reversible Calcium Alloying on Bulk and Indium (Sub)‐Micro Negative Electrodes for Calcium‐Based Batteries

Advanced Functional Materials, EarlyView.
Description: Indium metal serves as a reversible calcium‐alloying negative electrode. By transitioning from planar electrodes to powders and (sub‐)micron indium particles, the specific surface area is increased, improving the areal capacity density and cycling stability for calcium‐based batteries.
Wouter Monnens, Robert Markowski, Zhenyu Zhou, Claude Poleunis, Livia Grgurić, Jan Bitenc, Pingping Tan, Han‐Hung Hsu, Alexandru Vlad, Koen Binnemans, Jan Fransaer   +10 more
wiley   +1 more source

Organic anion transporter 2 transcript variant 1 shows broad ligand selectivity when expressed in multiple cell lines

Frontiers in Pharmacology, 2015
Organic anion transporter 2 (OAT2) is likely important for renal and hepatic drug elimination. Three variants of the OAT2 peptide sequence have been described – OAT2 transcript variant 1 (OAT2-tv1), OAT2 transcript variant 2 (OAT2-tv2) and OAT2 ...
Adam G Hotchkiss, Liam eBerrigan, Ryan M Pelis   +2 more
doaj   +1 more source

Characterisation and validation of drug transport and GLP-1R function in primary porcine proximal tubular cells [PDF]

, 2006
Overview kidney: Kidney is, beside the liver, one of the most important organs for the elimination of waste products, toxins, drugs and their metabolites. Due to the anatomy of the kidney, ultra filtrate leaving the glomerulus passes first the proximal
Schlatter, Philipp
core   +1 more source

Particle‐Level ZrO2 Atomic Layer Deposition Enables Fast‐Cycling and Long‐Life Graphite Cathodes for Dual‐Ion Batteries

Advanced Functional Materials, EarlyView.
A spatial location of atomic layer deposition (ALD)‐derived ZrO2 coatings is demonstrated to be a critical design parameter for stabilizing graphite cathodes in DIBs. Direct particle‐level ALD (PALD) screening of representative metal oxides identified ZrO2 as the coating that provides the most favorable balance of high‐rate capability and interfacial ...
Jieun Kang, Sung Eun Jo, Yunah Ji, Dongjoo Kim, Sungho Kim, Jaegeon Ryu, Jihwan An, Soojin Park   +7 more
wiley   +1 more source

Liver Receptor Homolog-1 Regulates Organic Anion Transporter 2 and Docetaxel Pharmacokinetics [PDF]

Drug Metabolism and Disposition, 2018
Organic anion transporter 2 (OAT2/SLC22A7) is an uptake transporter that plays an important role in drug disposition. Here, we investigate a potential role of liver receptor homolog-1 (Lrh-1) in regulation of Oat2 and docetaxel pharmacokinetics. Hepatoma cells (Hepa1-6 and HepG2 cells) were transfected with Lrh-1/LRH-1 expression vector or siRNA.
Fangjun, Yu, Tianpeng, Zhang, Lianxia, Guo, Baojian, Wu   +3 more
openaire   +2 more sources

Human Organic Anion Transporter 4 Is a Renal Apical Organic Anion/Dicarboxylate Exchanger in the Proximal Tubules

, 2004
Human organic anion transporter OAT4 is expressed in the kidney and placenta and mediates high-affinity transport of estrone-3-sulfate (E1S). Because a previous study demonstrated no trans-stimulatory effects by E1S, the mode of organic anion transport ...
Promsuk Jutabha, Rie Noshiro, Michio Takeda, Naohiko Anzai, Hitoshi Endou, Hiroki Miyazaki, Yoshikatsu Kanai, Sophapun Ekaratanawong, Samaisukh Sophasan   +8 more
core   +1 more source