Results 161 to 170 of about 9,926 (182)

Transmembrane Transport of cAMP and AMP Using a Two Component Small Molecule Transport System. [PDF]

Angew Chem Int Ed Engl
Rathnaweera UMC, Sam O, Norvaisa K, Marshall SR, Weerakonda Arachchige RDS, Chvojka M, Valkenier H, Busschaert N.   +7 more
europepmc   +1 more source

Atorvastatin Attenuates Vancomycin-Induced Nephrotoxicity via PPARα-Associated Regulation of SLC Transporters. [PDF]

Drug Des Devel Ther
Lin K, Li T, Kong X, Li T, Zuo Y, Dong D, Yang S, Zhu Y.   +7 more
europepmc   +1 more source

Expression and Functional Evaluation of ABC and SLC Transporters in Human Choroid Plexus Papilloma (HIBCPP) Cells: A Human Blood-Cerebrospinal Fluid Barrier Model. [PDF]

Pharm Res
Kurosawa T, Ohtsuki S, Ishikawa H, Schroten H, Schwerk C, Kubo Y, Deguchi Y.   +6 more
europepmc   +1 more source

Role of solute carrier transporters in the biodistribution and toxicity of chemotherapeutic drugs. [PDF]

Pharmacol Rev
Boeckman M, Drabison T, Germakovski A, Warmuth A, Ahmed B, Chowdhury AT, Hu S, Sprowl JA, Sparreboom A, Huang KM.   +9 more
europepmc   +1 more source

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Identification of a sodium-dependent organic anion transporter from rat adrenal gland

Biochemical and Biophysical Research Communications, 2004
In this study, a novel sodium-dependent organic anion transporter (Soat) was identified. Soat is expressed in rat brain, heart, kidney, lung, muscle, spleen, testis, adrenal gland, small intestine, and colon. The Soat protein consists of 370 amino acids and shows 42% and 31% overall amino acid sequence identity to the ileal sodium-dependent bile acid ...
Joachim Geyer, Ernst Petzinger
exaly   +3 more sources

Rare genetic variants in the sodium-dependent organic anion transporter SOAT (SLC10A6): Effects on transport function and membrane expression

Journal of Steroid Biochemistry and Molecular Biology, 2018
Sulfo-conjugated steroid hormones, such as dehydroepiandrosterone sulfate (DHEAS), pregnenolone sulfate or estrone-3-sulfate are abundant in the body, but are biologically inactive at classical androgen and estrogen steroid receptors. However, after carrier-mediated import and de-conjugation by the steroid sulfatase, these compounds participate in the ...
Joachim Geyer
exaly   +3 more sources

Transport of steroid 3-sulfates and steroid 17-sulfates by the sodium-dependent organic anion transporter SOAT (SLC10A6)

Journal of Steroid Biochemistry and Molecular Biology, 2018
The sodium-dependent organic anion transporter SOAT/Soat shows highly specific transport activity for sulfated steroids. SOAT substrates identified so far include dehydroepiandrosterone sulfate, 16α-hydroxydehydroepiandrosterone sulfate, estrone-3-sulfate, pregnenolone sulfate, 17β-estradiol-3-sulfate, and androstenediol sulfate.
Alberto Sanchez Guijo, , Joachim Geyer
exaly   +3 more sources

The polymorphism L204F affects transport and membrane expression of the sodium-dependent organic anion transporter SOAT (SLC10A6)

Journal of Steroid Biochemistry and Molecular Biology, 2018
Sodium-dependent organic anion transporter (SOAT) represents a membrane transporter specific for sulfated steroid hormones, which are supposed to participate in the regulation of reproductive processes. In man, SOAT shows predominant mRNA expression in the testis and here was localized to primary spermatocytes.
Sabine Kliesch, Joachim Geyer, Martin Bergmann   +2 more
exaly   +3 more sources

Cloning and functional characterization of the mouse sodium-dependent organic anion transporter Soat (Slc10a6)

Journal of Steroid Biochemistry and Molecular Biology, 2013
The sodium-dependent organic anion transporter SOAT is a member of the Solute Carrier Family SLC10. In man, this carrier is predominantly expressed in the testis and has transport activity for sulfoconjugated steroid hormones. Here, we report on cloning, expression analysis and functional characterization of the mouse Soat (mSoat) and compare its ...
Ralph Brehm, Joachim Geyer, Bernhard Ugele   +2 more
exaly   +3 more sources

Digoxin Is Not a Substrate for Organic Anion-Transporting Polypeptide Transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but Is a Substrate for a Sodium-Dependent Transporter Expressed in HEK293 Cells

Drug Metabolism and Disposition, 2011
Digoxin, an orally administered cardiac glycoside cardiovascular drug, has a narrow therapeutic window. Circulating digoxin levels (maximal concentration of ∼1.5 ng/ml) require careful monitoring, and the potential for drug-drug interactions (DDI) is a concern. Increases in digoxin plasma exposure caused by inhibition of P-glycoprotein (P-gp) have been
Mitchell E, Taub, Kirsten, Mease, Rucha S, Sane, Cory A, Watson, Liangfu, Chen, Harma, Ellens, Brad, Hirakawa, Eric L, Reyner, Marton, Jani, Caroline A, Lee   +9 more
openaire   +2 more sources