Results 111 to 120 of about 2,175,797 (285)

Inhibitory effects of Kampo medicines, Keishibukuryogan and Shakuyakukanzoto, on the substrate uptake activities of solute carrier organic anion transporters

, 2018
The aim of this study was to assess the effects of Keishibukuryogan (K-06) and Shakuyakukanzoto (TJ-68), commercial herbal medicines, on the substrate uptake activities of renal organic anion transporters.
Ho-Sung Lee, Munju Cho, Ho Jung Shin, Dal-Seok Oh, Seung Hoon Lee   +4 more
core   +1 more source

Neuromorphic Electronics for Intelligence Everywhere: Emerging Devices, Flexible Platforms, and Scalable System Architectures

Advanced Materials, EarlyView.
The perspective presents an integrated view of neuromorphic technologies, from device physics to real‐time applicability, while highlighting the necessity of full‐stack co‐optimization. By outlining practical hardware‐level strategies to exploit device behavior and mitigate non‐idealities, it shows pathways for building efficient, scalable, and ...
Kapil Bhardwaj, Roshni Satheesh Babu, Yuxin Xia, Eva Bestelink, Radu Sporea, Nikos Hastas, Ioannis Zeimpekis, Dimitra G. Georgiadou, Sayani Majumdar   +8 more
wiley   +1 more source

Carrier-Mediated and Energy-Dependent Uptake and Efflux of Deoxynivalenol in Mammalian Cells

Scientific Reports, 2017
Deoxynivalenol (DON) is one of the most abundant mycotoxins and exerts many adverse effects on humans and animals. To date, the transporting mechanism of DON in mammalian cells remains unclear. In this study, the parallel artificial membrane permeability
Xiaoming Li, Peiqiang Mu, Jikai Wen, Yiqun Deng   +3 more
doaj   +1 more source

Renal Organic Anion Transporters 1 and 3 In Vitro: Gone but Not Forgotten. [PDF]

Int J Mol Sci, 2023
Caetano-Pinto P, Stahl SH.
europepmc   +1 more source

Comparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict drug induced hepatotoxicity [PDF]

, 2013
Human hepatocytes are the gold standard for toxicological studies but they have several drawbacks, like scarce availability, high inter-individual variability, a short lifetime, which limits their applicability.
Jemnitz, Katalin, Monika Szabo, Katalin Jemnitz, Veres, Zsuzsa, Zsuzsa Veres, Baranyai, Zsolt, Zsolt Baranyai, Szabo, Monika, Ferenc Jakab, Jakab, Ferenc   +9 more
core   +2 more sources

When Poor Exciton Dissociation Limits Photocurrents in Organic Solar Cells: Why Low Offset Non‐Fullerene Acceptor Blends Can't Be Efficient

Advanced Materials, EarlyView.
The energetic offset between the donor and the acceptor components in organic photoactive layers is central to the tradeoff between photovoltage and photocurrent losses. This Perspective covers the most important issues surrounding this topic in non‐fullerene acceptor blends, from the difficulty of accurately determining state energies and driving ...
Dieter Neher, Manasi Pranav
wiley   +1 more source

The interaction of flavonoids, alkaloids, and terpenoids with the major drug transporters in the organic anion transporting polypeptide and organic anion transporter families

Acta Pharmaceutica Sinica B
Natural compounds are ubiquitously found in the plant kingdom and are well-known for their beneficial effects on human health. The easy accessibility and the relatively affordable price make them popular choices for self-medication and/or as part of a ...
Zichong Li, Xuyang Wang, Chaomin Pan, Mei Hong   +3 more
doaj   +1 more source

Diversity of function and mechanism in a family of organic anion transporters. [PDF]

Curr Opin Struct Biol, 2022
Li F, Eriksen J, Finer-Moore J, Stroud RM, Edwards RH.   +4 more
europepmc   +1 more source

Resistance to Overdoping Allows Over 2000 S cm−1 Conductivity in P(g3BTTT) With Anion‐Exchange Doping

Advanced Materials, EarlyView.
Anion‐exchange doping of conjugated polymers is an effective way to achieve high conductivities. Here, we report over 2000 S cm−1 electrical conductivity for doped P(g3BTTT). In addition, we show that P(g3BTTT) sustains exceptionally high doping levels without any drop in the charge mobility.
Basil Hunger, Maximilian M. Horn, Eva Röck, Diego Rosas Villalva, Lize Bynens, Jochen Vanderspikken, Christina Kousseff, Silène Gobeil, Olivier Bardagot, Nesibe Akmanşen‐Kalayci, Sarah H. Tolbert, Iain McCulloch, Wouter Maes, Demetra Tsokkou, Natalie Banerji   +14 more
wiley   +1 more source

In Vitro Inhibitory Effects of APINACA on Human Major Cytochrome P450, UDP-Glucuronosyltransferase Enzymes, and Drug Transporters

Molecules, 2019
APINACA (known as AKB48, N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide), an indazole carboxamide synthetic cannabinoid, has been used worldwide as a new psychoactive substance.
Sunjoo Kim, Won-Gu Choi, Mihwa Kwon, Sowon Lee, Yong-Yeon Cho, Joo Young Lee, Han Chang Kang, Im-Sook Song, Hye Suk Lee   +8 more
doaj   +1 more source