Results 91 to 100 of about 43,519 (302)

From Food to Power: Hydrogel Thermoelectrics for Ingestible Electronics

Advanced Functional Materials, EarlyView.
We introduce a fully edible thermoelectric–electrochromic platform that harvests heat from food and converts it into a visible color change. N‐type and p‐type hydrogel thermoelectric generators connected in series power anthocyanin‐based electrochromic displays, demonstrating the feasibility of safe, biodegradable, ingestible systems for on‐food ...
Antonia Georgopoulou, Bokeon Kwak, Dario Floreano, Esther Amstad   +3 more
wiley   +1 more source

Role of Transporters in Central Nervous System Drug Delivery and Blood-Brain Barrier Protection: Relevance to Treatment of Stroke

Journal of Central Nervous System Disease, 2017
Ischemic stroke is a leading cause of morbidity and mortality in the United States. The only approved pharmacologic treatment for ischemic stroke is thrombolysis via recombinant tissue plasminogen activator (r-tPA). A short therapeutic window and serious
Hrvoje Brzica, Wazir Abdullahi, Kathryn Ibbotson, Patrick T Ronaldson   +3 more
doaj   +1 more source

Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice [PDF]

, 2017
Introduction : Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development.
De Lombaerde, Stef, De Vos, Filip, Devisscher, Lindsey, Kersemans, Ken, Neyt, Sara, Van Vlierberghe, Hans, Vanhove, Christian, Verhoeven, Jeroen   +7 more
core   +3 more sources

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

Effect of Statin Lipophilicity on the Proliferation of Hepatocellular Carcinoma Cells

Biology
The HMG-CoA reductase inhibitors, statins, are drugs used globally for lowering the level of cholesterol in the blood. Different clinical studies of statins in cancer patients have indicated a decrease in cancer mortality, particularly in patients using ...
Goda Glebavičiūtė, Akshay Kumar Vijaya, Giulio Preta   +2 more
doaj   +1 more source

ORGANIC ANION TRANSPORTERS. MOLECULAR DIVERSITY, STRUCTURE, CONTRIBUTION TO THE FUNCTIONING OF THE XENOBIOTIC BIOTRANSFORMATION SYSTEM IN ANIMALS (A REWIEW)

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2017
The organic anion transporter (OAT) subfamily, which constitutes roughly a half of the SLC22 transporter family and shares many structural characteristics with other MFS proteins, has received a great deal of attention because of its role in handling of ...
Lev Smirnov, Irina Sukhovskaya, Ekaterina Borvinskaya   +2 more
doaj   +1 more source

Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics [PDF]

, 2015
Membrane transporters play an essential role in the transport of endogenous and exogenous compounds, and consequently they mediate the uptake, distribution, and excretion of many drugs. The clinical relevance of transporters in drug disposition and their
Knibbe, C.A.J. (Catherijne), Mooij, M.G. (Miriam), Nies, A.T. (Anne T.), Schaeffeler, E. (Elke), Schwab, M. (Matthias), Tibboel, D. (Dick), Wildt, S.N. (Saskia) de   +6 more
core   +5 more sources

Scalable Polyelectrolyte Complex‐Based Sorbent With Hourly Sorption−Desorption Cycles for Multicyclic Atmospheric Water Harvesting in Arid Environments

Advanced Functional Materials, EarlyView.
A polyelectrolyte complex‐based sorbent is produced by scalable, environmentally benign aqueous phase inversion. Its porous, LiCl‐ and GO‐integrated architecture enables hourly adsorption−desorption cycles at low relative humidity (RH < 30%). A large‐scale prototype achieves multicyclic, solar‐driven atmospheric water harvesting of 1.37 L kg−1 day−1 ...
Seung‐Hwan Oh, Incheol Heo, Won Cheol Yoo, Soo‐Hyung Choi   +3 more
wiley   +1 more source

Interactions of Human- and Rat-Organic Anion Transporters With Pravastatin and Cimetidine

Journal of Pharmacological Sciences, 2004
We have elucidated the interactions of human and rat organic anion transporters (hOATs and rOATs) with pravastatin and cimetidine. Pravastatin inhibited hOAT1/rOAT1, hOAT2/rOAT2, hOAT3/rOAT3, and hOAT4. The mode of inhibition was noncompetitive for hOAT1
Suparat Khamdang, Michio Takeda, Minoru Shimoda, Rie Noshiro, Shinichi Narikawa, Xiu-Lin Huang, Atsushi Enomoto, Pawinee Piyachaturawat, Hitoshi Endou   +8 more
doaj   +1 more source

In Vitro Interaction of AB-FUBINACA with Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes and Drug Transporters

Molecules, 2020
AB-FUBINACA, a synthetic indazole carboxamide cannabinoid, has been used worldwide as a new psychoactive substance. Because drug abusers take various drugs concomitantly, it is necessary to explore potential AB-FUBINACA-induced drug–drug interactions ...
Sunjoo Kim, Dong Kyun Kim, Yongho Shin, Ji-Hyeon Jeon, Im-Sook Song, Hye Suk Lee   +5 more
doaj   +1 more source