Results 81 to 90 of about 43,519 (302)

A Novel Human Organic Anion Transporter NPT4 Mediates the Transport of Ochratoxin A

Journal of Pharmacological Sciences, 2011
.: In the present study, we investigated the transport of nephrotoxic mycotoxin ochratoxin A (OTxA) by a novel human organic anion transporter hNPT4 using the Xenopus oocyte expression system.
Promsuk Jutabha, Naohiko Anzai, Keitaro Hayashi, Mariko Domae, Kohsuke Uchida, Hitoshi Endou, Hiroyuki Sakurai   +6 more
doaj   +1 more source

Managing Pharmacotherapy in People Living With HIV and Concomitant Malignancy. [PDF]

, 2019
Objective: To describe data with selected malignancies in people living with HIV (PLWH) and HIV in individuals affected by both conditions and to summarize drug-drug interactions (DDIs) with clinical recommendations for point-of-care review of ...
Chan, Alexandre, Klibanov, Olga, Olin, Jacqueline L, Spooner, Linda M   +3 more
core   +1 more source

The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs [PDF]

, 2009
Drug transporters are recognized as key players in the processes of drug absorption, distribution, metabolism, and elimination. The localization of uptake and efflux transporters in organs responsible for drug biotransformation and excretion gives ...
Sarah Shugarts, Leslie Z. Benet, RL Juliano, MF Fromm, CP Landowski, N Mizuno, CY Wu, GL Amidon, C Srimaroeng, ZM Zaïr, G Ciarimboli, B Hagenbuch, Y Toyoda, SF Zhou, H Kusuhara, S Choudhuri, BL Urquhart, AD Mottino, LW Chinn, K Maeda, T Nakamura, JE Montfoort van, M Okabe, L Li, LM Satlin, C Mahagita, A Kosters, T Takagi, NA Kasim, Y Yang, LZ Benet, H Lennernäs, N Li, M Katoh, X Cao, R Hayeshi, JM Arthur, D Sun, ML Chen, Y Shirasaka, U Fagerholm, CY Wu, X Cao, CL Cummins, CL Cummins, UI Schwarz, K Westphal, JS Lee, AL Sesink, Y Su, H Glaeser, Y Koitabashi, A Dahan, B Greiner, JM Custodio, RG Tirona, Y Su, T Watanabe, YY Lau, HX Zheng, JW Deng, Y Shu, X Tian, N Zelcer, RB Parker, LZ Benet, GA Kullak-Ublick, C Solas, S Zhou, SX Peng, C Tannergren, S Sahin, Y Kato, C Luna- Tortós, K Engel, M Zhou, BL Urquhart, MO Magnusson, N Ishiguro, Q Wang, DG Bailey, SR Vavricka, U Muenster, K Takenaka, DA Volpe, C Hilgendorf, M Lohitnavy, T Lavé, SS Buck De, Z Wang, N Parrott, A Bonen, M Grube, W Lee, MJ Bijvelds, JH Gray, RP Owen, A Bodo, Q Tian, L Ci, RD Huber, B Gao, G Jedlitschky, M Farias, SY Yao, D Kirat, D Meredith, I Knutter, DA Groneberg, M Hayer-Zillgen, S Sakamoto, H Li, JY Li, H Yabuuchi, I Elimrani, ILMH Aye, JD Allen, O Janneh, K Fujiwara, H Potschka, E Pollex, F Boraldi, W Lin, KR Robillard, AJ Smith, M Hirano, E Jigorel, EM Leslie, RB Kim, S Khamdung, S Halwachs, A Geick, O Burk, HR Kast, J Staudinger, M Assem, I Szatmari, M Ananthanarayanan, JJ Eloranta, Y Miki, JM Maglich, D Jung, Y Morita, S Hoffmeyer, Y Kurata, SY Yi, FA Jong de, A Sparreboom, A Sparreboom, W Zhang, Y Nishizato, J Mwinyi, M Niemi, M Niemi, I Ieiri, MK Pasanen, W Zhang, DA Katz, X Xiang, S Oswald, SV Vormfelde, M Miura   +161 more
core   +3 more sources

Zwitterionic Self‐Assembled Monolayer for Simultaneous Noise Suppression and Hole Extraction in High‐Performance Near‐Infrared Organic Photodetectors

Advanced Functional Materials, EarlyView.
This study presents a new hole transporting material (HTM) mechanism for self‐assembled monolayers in near‐infrared organic photodetectors. The formation of zwitterions induces a strong electric field that significantly increases the work function of HTM‐coated indium tin oxide substrates. The devices exhibit low dark current and noise, along with high
Jiyoung Shin, Gyeong Min Lee, Juyeon Shin, Jaewoong Kim, Tae Hyuk Kim, Do Yeon Kim, Myeong In Kim, Kyeounghak Kim, Jae Won Shim, In Hwan Jung   +9 more
wiley   +1 more source

Organic anion transporters and their influence on the toxicity of β-lactam antibiotics

Безопасность и риск фармакотерапии, 2018
This review article describes the classification and mechanism of action of organic anion transporters (OAT). The influence of certain members of this family of transporters on the pharmacokinetics of β-lactam antibiotics.
V. A. Evteev, O. V. Muslimova, I. A. Mazerkina, N. D. Bunyatyan, E. V. Shikh, R. E. Kazakov   +5 more
doaj  

Altered Renal Expression of Relevant Clinical Drug Transporters in Different Models of Acute Uremia in Rats. Role of Urea Levels

Cellular Physiology and Biochemistry, 2015
Background/Aims: Organic anion transporter 1 (Oat1) and 3 (Oat3) are organic anion transporters that play critical roles in the body disposition of numerous clinically important drugs.
Anabel Brandoni, Adriana M. Torres
doaj   +1 more source

The altered renal and hepatic expression of solute carrier transporters (SLCs) in type 1 diabetic mice. [PDF]

PLoS ONE, 2015
Diabetes mellitus is a chronic metabolic disorder that significantly affects human health and well-being. The Solute carrier transporters (SLCs), particularly the Organic anion/cation transporters (Oats/Octs/Octns), Organic anion transporting ...
Chenghao Xu, Ling Zhu, Ting Chan, Xiaoxi Lu, Weiyong Shen, Mark C Gillies, Fanfan Zhou   +6 more
doaj   +1 more source

Na+-dependent and Na+-independent betaine transport across the apical membrane of rat renal epithelium [PDF]

, 2015
The low renal excretion of betaine indicates that the kidney efficiently reabsorbs the betaine filtered by the glomeruli but the mechanisms involved in such a process have been scarcely investigated.
Calonge Castrillo, María Luisa, Cano Rodríguez, María Mercedes, Ilundáin Larrañeta, María Anunciación Ana   +2 more
core   +1 more source

Covalent Organic Frameworks for Photocatalytic CO2 Reduction: Metal Integration Principles, Strategies and Functions

Advanced Functional Materials, EarlyView.
Covalent organic frameworks (COFs) with metals have been recognized as versatile platforms for photocatalytic CO2 reduction (CO2PRR). Herein, an overview of metal integration strategies for COFs is systematically summarized. Regulatory mechanisms and structure–activity relationships between metal integration and COF‐based CO2PRR are emphasized.
Jie He, Minxian Zhang, Jinqiang Zhang, Hongqi Sun, Shaobin Wang, Xiaoguang Duan   +5 more
wiley   +1 more source

Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11) [PDF]

, 2013
Active components of complementary/alternative medicines and natural supplements are often anionic compounds and flavonoids. As such, organic anion transporters (OATs) may play a key role in their pharmacokinetic and pharmacological profiles, and ...
Sweet, Douglas H., Wang, Li
core   +3 more sources