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Regulation of organic anion transporters

, 2016
Organic anion transporters (OATs) are a group of transporters that interact with organic anionic molecules or zwitterions in our body. OATs mainly exist in the kidney and mediate the disposition of a wide range of endogenous physiological substances, exogenous clinical drugs and toxins.
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Interaction of Human Organic Anion Transporters 2 and 4 with Organic Anion Transport Inhibitors

The Journal of Pharmacology and Experimental Therapeutics, 2002
The organic anion transport system is involved in the tubular excretion and reabsorption of various drugs and substances. The purpose of this study was to characterize the effects of various organic anion transport inhibitors on renal organic anion transport using proximal tubule cells stably expressing human organic anion transporter 2 (hOAT2) and ...
Atsushi, Enomoto, Michio, Takeda, Minoru, Shimoda, Shinichi, Narikawa, Yukari, Kobayashi, Yasuna, Kobayashi, Toshinori, Yamamoto, Takashi, Sekine, Seok Ho, Cha, Toshimitsu, Niwa, Hitoshi, Endou   +10 more
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Carrier-mediated transport of quercetin conjugates: Involvement of organic anion transporters and organic anion transporting polypeptides

Biochemical Pharmacology, 2012
Flavonoids modulate cell signaling and inhibit oxidative enzymes. After oral consumption, they circulate in human plasma as amphiphilic glucuronide or sulfate conjugates, but it is unknown how these physiological metabolites permeate into cells. We examined the mechanisms of uptake of these conjugates into hepatocellular carcinoma (HepG2) cells, and ...
Chi Chun, Wong, Yasutoshi, Akiyama, Takaaki, Abe, Jonathan D, Lippiat, Caroline, Orfila, Gary, Williamson   +5 more
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Renal Transport of Organic Anions and Cations

Comprehensive Physiology, 2011
Abstract Organic anions and cations (OAs and OCs, respectively) comprise an extraordinarily diverse array of compounds of physiological, pharmacological, and toxicological importance. The kidney, primarily the renal proximal tubule, plays a critical role in regulating the plasma concentrations of these organic ...
Ryan M, Pelis, Stephen H, Wright
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Renal transport of organic anions

Current Opinion in Nephrology and Hypertension, 1998
This review deals with the different transport mechanisms mediating the apical and basolateral transport of organic anions, all of which are restricted to the proximal tubule. Several transport mechanisms, such as the para-aminohippurate basolateral transporter and the apical proton coupled di- and tripeptide transporter have been cloned, and their ...
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Organic Anion Transporters and Their Implications in Pharmacotherapy

Pharmacological Reviews, 2012
Organic anion transporters play an essential role in the distribution and excretion of numerous endogenous metabolic products and exogenous organic anions, including a host of widely prescribed drugs. The expression and activity of these transporters is influenced by several conditions, including transcriptional regulation, gender-dependent regulation,
Arian, Emami Riedmaier, Anne T, Nies, Elke, Schaeffeler, Matthias, Schwab   +3 more
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Transporters for Bile Acids and Organic Anions

2002
The liver is one of the most important organs in the detoxification of xenobiotics. Compounds in the circulating blood are taken up by hepatocytes and then are metabolized and/or excreted into the bile. Many kinds of drugs and their metabolites are transported across the sinusoidal and bile canalicular membranes via carriermediated mechanisms.
H, Suzuki, Y, Sugiyama
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Hydroxide Anion Transport in Covalent Organic Frameworks

Journal of the American Chemical Society, 2021
Hydroxide anion transport is essential for alkaline fuel cells, but hydroxide anion has an inherently low conductivity owing to its small diffusion coefficient and high mass. Ordered open channels found in covalent organic frameworks are promising as pathways to enable hydroxide anion transport, but this remains to be explored.
Shanshan Tao, Hong Xu, Qing Xu, Yuh Hijikata, Qiuhong Jiang, Stephan Irle, Donglin Jiang   +6 more
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Regulation of organic anion transporters

2021
The members of the organic anion transporter (OAT) family are mainly expressed in kidney, liver, placenta, intestine, and brain. These transporters are key players for the translocation of various substances into and out of cells, such as clinical drugs, pesticides, signaling molecules, heavy metal conjugates, components of phytomedicines, and toxins ...
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Characterization of ochratoxin A transport by human organic anion transporters

Life Sciences, 2001
The purpose of this study was to investigate the characteristics of ochratoxin A (OTA) transport by multispecific human organic anion transporters (hOAT1 and hOAT3, respectively) using the second segment of proximal tubule (S2) cells from mice stably expressing hOAT1 and hOAT3 (S2 hOAT1 and S2 hOAT3).
K Y, Jung, M, Takeda, D K, Kim, A, Tojo, S, Narikawa, B S, Yoo, M, Hosoyamada, S H, Cha, T, Sekine, H, Endou   +9 more
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