Results 261 to 270 of about 43,519 (302)
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Interaction of Human Organic Anion Transporters 2 and 4 with Organic Anion Transport Inhibitors
The Journal of Pharmacology and Experimental Therapeutics, 2002The organic anion transport system is involved in the tubular excretion and reabsorption of various drugs and substances. The purpose of this study was to characterize the effects of various organic anion transport inhibitors on renal organic anion transport using proximal tubule cells stably expressing human organic anion transporter 2 (hOAT2) and ...
Atsushi, Enomoto +10 more
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European Journal of Pharmacology, 2001
The organic anion transport system is involved in the tubular excretion of various clinically important drugs. The purpose of this study was to characterize the effects of various organic anion transport inhibitors on organic anion transport using proximal tubule cells stably expressing human organic anion transporter 1 (human-OAT1) and human-OAT3 ...
M, Takeda +5 more
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The organic anion transport system is involved in the tubular excretion of various clinically important drugs. The purpose of this study was to characterize the effects of various organic anion transport inhibitors on organic anion transport using proximal tubule cells stably expressing human organic anion transporter 1 (human-OAT1) and human-OAT3 ...
M, Takeda +5 more
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Biochemical Pharmacology, 2012
Flavonoids modulate cell signaling and inhibit oxidative enzymes. After oral consumption, they circulate in human plasma as amphiphilic glucuronide or sulfate conjugates, but it is unknown how these physiological metabolites permeate into cells. We examined the mechanisms of uptake of these conjugates into hepatocellular carcinoma (HepG2) cells, and ...
Chi Chun, Wong +5 more
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Flavonoids modulate cell signaling and inhibit oxidative enzymes. After oral consumption, they circulate in human plasma as amphiphilic glucuronide or sulfate conjugates, but it is unknown how these physiological metabolites permeate into cells. We examined the mechanisms of uptake of these conjugates into hepatocellular carcinoma (HepG2) cells, and ...
Chi Chun, Wong +5 more
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Renal transport of organic anions
Current Opinion in Nephrology and Hypertension, 1998This review deals with the different transport mechanisms mediating the apical and basolateral transport of organic anions, all of which are restricted to the proximal tubule. Several transport mechanisms, such as the para-aminohippurate basolateral transporter and the apical proton coupled di- and tripeptide transporter have been cloned, and their ...
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Hydroxide Anion Transport in Covalent Organic Frameworks
Journal of the American Chemical Society, 2021Hydroxide anion transport is essential for alkaline fuel cells, but hydroxide anion has an inherently low conductivity owing to its small diffusion coefficient and high mass. Ordered open channels found in covalent organic frameworks are promising as pathways to enable hydroxide anion transport, but this remains to be explored.
Shanshan Tao +6 more
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Hepatocellular Sinusoidal Membrane Organic Anion Transport and Transporters
Seminars in Liver Disease, 1996This review focuses on oatp, a rat liver protein that has been cloned on the basis of its ability to transport organic anions such as bilirubin and sulfobromophthalein (BSP). Although other proteins have been suggested as having bilirubin or BSP transport activity, these data have primarily been indirect, and their cloning and expression have not yet ...
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Regulation of organic anion transporters
2021The members of the organic anion transporter (OAT) family are mainly expressed in kidney, liver, placenta, intestine, and brain. These transporters are key players for the translocation of various substances into and out of cells, such as clinical drugs, pesticides, signaling molecules, heavy metal conjugates, components of phytomedicines, and toxins ...
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Molecular physiology of renal organic anion transporters
American Journal of Physiology-Renal Physiology, 2006Recent advances in molecular biology have identified three organic anion transporter families: the organic anion transporter (OAT) family encoded by SLC22A, the organic anion transporting peptide (OATP) family encoded by SLC21A ( SLCO), and the multidrug resistance-associated protein (MRP) family encoded by ABCC.
Takashi, Sekine +2 more
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Renal Transport of Organic Anions and Cations
Comprehensive Physiology, 2011AbstractOrganic anions and cations (OAs and OCs, respectively) comprise an extraordinarily diverse array of compounds of physiological, pharmacological, and toxicological importance. The kidney, primarily the renal proximal tubule, plays a critical role in regulating the plasma concentrations of these organic electrolytes and in clearing the body of ...
Ryan M, Pelis, Stephen H, Wright
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Novel aspects of renal organic anion transporters
Current Opinion in Nephrology and Hypertension, 2003Organic anion transporters, transmembrane proteins present in the renal proximal tubule, are a critical component of the human drug excretion machinery. Recent advances have clarified the function of these transporters, with broad clinical implications for pharmacogenetics, drug interactions and adverse reactions.
Satish A, Eraly +3 more
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