Results 261 to 270 of about 21,525 (288)

Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters

European Journal of Pharmacology, 2001
The organic anion transport system is involved in the tubular excretion of various clinically important drugs. The purpose of this study was to characterize the effects of various organic anion transport inhibitors on organic anion transport using proximal tubule cells stably expressing human organic anion transporter 1 (human-OAT1) and human-OAT3 ...
M, Takeda, S, Narikawa, M, Hosoyamada, S H, Cha, T, Sekine, H, Endou   +5 more
openaire   +2 more sources

Novel aspects of renal organic anion transporters

Current Opinion in Nephrology and Hypertension, 2003
Organic anion transporters, transmembrane proteins present in the renal proximal tubule, are a critical component of the human drug excretion machinery. Recent advances have clarified the function of these transporters, with broad clinical implications for pharmacogenetics, drug interactions and adverse reactions.
Satish A, Eraly, Roland C, Blantz, Vibha, Bhatnagar, Sanjay K, Nigam   +3 more
openaire   +2 more sources

Organic anion transport across the choroid plexus

Microscopy Research and Technique, 2000
Several organic anion transport systems have recently been identified and localized at the apical and basolateral plasma membrane domains of choroid plexus epithelial cells. These organic anion transporters include (1) indirectly coupled Na(+)/dicarboxylate cotransport and dicarboxylate/organic anion exchange, which is represented on the molecular ...
Gao, B., Meier, P. J.
openaire   +2 more sources

The multispecific organic anion transporter (OAT) family

Pflügers Archiv - European Journal of Physiology, 2000
Organic anion transporters play important roles in the elimination of a variety of endogenous substances, xenobiotics and their metabolites from the body. During the last decade, molecular cloning has identified several families of multispecific organic anion transporters mediating the renal and hepatic elimination of organic anions and, most recently,
T, Sekine, S H, Cha, H, Endou
openaire   +2 more sources

Hepatocellular Sinusoidal Membrane Organic Anion Transport and Transporters

Seminars in Liver Disease, 1996
This review focuses on oatp, a rat liver protein that has been cloned on the basis of its ability to transport organic anions such as bilirubin and sulfobromophthalein (BSP). Although other proteins have been suggested as having bilirubin or BSP transport activity, these data have primarily been indirect, and their cloning and expression have not yet ...
openaire   +2 more sources

Organic Anion Transporters and Organic Anion Transporting Polypeptides

2021
Alan Talevi, Carolina L. Bellera
openaire   +1 more source

Regulation of organic anion transporters

2013
Human organic anion transporters (hOATs) play critical roles in the body disposition of clinically important drugs. Understanding the regulation of hOATs has profound clinical significance. My thesis work focuses on delineating molecular and cellular mechanisms underlying hOAT regulation, and consists of three parts.
openaire   +1 more source

Development of organic anion transport in the liver

Experimental and Toxicologic Pathology, 1996
A, Barth, C, Fleck, W, Klinger
openaire   +2 more sources

Identification of Prognostic Organic Cation and Anion Transporters in Different Cancer Entities by In Silico Analysis

International Journal of Molecular Sciences, 2020
Edemir Bayram
exaly  

Characterization of uremic toxin transport by organic anion transporters in the kidney

Kidney International, 2004
Tsuneo Deguchi, Hiroyuki Kusuhara, Akira Takadate   +2 more
exaly