Results 271 to 280 of about 43,519 (302)
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Organic anion transport across the choroid plexus
Microscopy Research and Technique, 2000Several organic anion transport systems have recently been identified and localized at the apical and basolateral plasma membrane domains of choroid plexus epithelial cells. These organic anion transporters include (1) indirectly coupled Na(+)/dicarboxylate cotransport and dicarboxylate/organic anion exchange, which is represented on the molecular ...
Gao, B., Meier, P. J.
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The multispecific organic anion transporter (OAT) family
Pflügers Archiv - European Journal of Physiology, 2000Organic anion transporters play important roles in the elimination of a variety of endogenous substances, xenobiotics and their metabolites from the body. During the last decade, molecular cloning has identified several families of multispecific organic anion transporters mediating the renal and hepatic elimination of organic anions and, most recently,
T, Sekine, S H, Cha, H, Endou
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Pharmacogenomics of organic anion-transporting polypeptides (OATP)
Advanced Drug Delivery Reviews, 2002The organic anion-transporting polypeptides (OATP) represent a family of proteins responsible for the membrane transport of a large number of endogenous and xenobiotic compounds with diverse chemical characteristics. OATPs are expressed in liver, kidney, brain and intestine suggesting that they may play a critical role in drug disposition.
Rommel G, Tirona, Richard B, Kim
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Transporters for Bile Acids and Organic Anions
2002The liver is one of the most important organs in the detoxification of xenobiotics. Compounds in the circulating blood are taken up by hepatocytes and then are metabolized and/or excreted into the bile. Many kinds of drugs and their metabolites are transported across the sinusoidal and bile canalicular membranes via carriermediated mechanisms.
H, Suzuki, Y, Sugiyama
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Endocrine Regulation of Rat Organic Anion Transporters
Drug Metabolism and Disposition, 2003Messenger RNA levels of rat organic anion transporter 1 (Oat1; Slc22a6) and Oat2 (Slc22a7) in kidney and Oat3 (Slc22a8) in liver are gender-predominant. Oat1 and Oat3 are male-predominant, whereas Oat2 is female-predominant. Gonadectomized and hypophysectomized (HX) rats were studied to determine whether sex steroids and/or growth hormone (GH) are ...
Susan C N, Buist +2 more
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Organic Anion Transporters and Organic Anion Transporting Polypeptides
2021Alan Talevi, Carolina L. Bellera
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Regulation of organic anion transporters
2016Organic anion transporters (OATs) are a group of transporters that interact with organic anionic molecules or zwitterions in our body. OATs mainly exist in the kidney and mediate the disposition of a wide range of endogenous physiological substances, exogenous clinical drugs and toxins.
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Regulation of organic anion transporters
2013Human organic anion transporters (hOATs) play critical roles in the body disposition of clinically important drugs. Understanding the regulation of hOATs has profound clinical significance. My thesis work focuses on delineating molecular and cellular mechanisms underlying hOAT regulation, and consists of three parts.
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