Lead and Zinc Uptake and Toxicity in Maize and Their Management
Plants, 2022 Soil contamination with heavy metals is a global problem, and these metals can reach the food chain through uptake by plants, endangering human health.
Tayebeh Abedi +2 more
doaj +1 more source
The FASEB Journal, 2015 The two drug transporters OATP1B3 and OCT1 are expressed at the basolateral membrane of human hepatocytes. In a search for potential interacting proteins a modified yeast‐two‐hybrid screen (DUALmembrane screen) identified OCT1 as an interaction partner for OATP1B3.
Jessica Shoop +3 more
openaire +1 more source
Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy [PDF]
Drug Metabolism and Disposition, 2013 Polyspecific organic cation (OC) transporters play important roles in the disposition of clinically used drugs, including drugs used during pregnancy. Pregnancy is known to alter the expression of drug-metabolizing enzymes and transporters, but its specific effect on OC transporters has not been well defined.
Nora, Lee +6 more
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Organic Cation Transporter 3: A Cellular Mechanism Underlying Rapid, Non-Genomic Glucocorticoid Regulation of Monoaminergic Neurotransmission, Physiology, and Behavior [PDF]
, 2018 Corticosteroid hormones act at intracellular glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) to alter gene expression, leading to diverse physiological and behavioral responses.
Gasser, Paul J., Lowry, Christopher A.
core +2 more sources
The Affinity of the Organic Cation Transporter rOCT1 Is Increased by Protein Kinase C-Dependent Phosphorylation [PDF]
Journal of the American Society of Nephrology, 2000 Abstract. Members of the organic cation transporter (OCT) family are mainly expressed in kidney, liver, intestine, and brain. The regulation of the OCT type 1 from rat (rOCT1) stably transfected in HEK293 cells was examined using a fluorimetric technique, 1-[3H]methyl-4-phenylpyridinium uptake studies, and fast-whole-cell patch-
Thomas, Mehrens +8 more
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Behaviours of natural organic matter in membrane filtration for surface water treatment : a review [PDF]
, 2006 Membrane application in surface water treatment provides many advantages over conventional treatment. However, this effort is hampered by the fouling issue, which restricts its widespread application due to increases in hydraulic resistances, operational
Ismail, A. F. +2 more
core +1 more source
Interactions of Tyrosine Kinase Inhibitors with Organic Cation Transporters and Multidrug and Toxic Compound Extrusion Proteins [PDF]
Molecular Cancer Therapeutics, 2011 Abstract The drug–drug interaction (DDI) potential of tyrosine kinase inhibitors (TKI) as interacting drugs via transporter inhibition has not been fully assessed. Here, we estimated the half maximal inhibitory concentration (IC50) values for 8 small-molecule TKIs (imatinib, dasatinib, nilotinib, gefitinib, erlotinib, sunitinib ...
Tsuyoshi, Minematsu +1 more
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Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain [PDF]
, 2017 There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including autism, neonatal seizures, and epilepsy, which are not related to its effects on the kidney but ...
Erker, Thomas +7 more
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Enantioselective Drug Recognition by Drug Transporters
Molecules, 2018 Drug transporters mediate the absorption, tissue distribution, and excretion of drugs. The cDNAs of P-glycoprotein, multidrug resistance proteins (MRPs/ABCC), breast cancer resistance protein (BCRP/ABCG2), peptide transporters (PEPTs/SLC15), proton ...
Yuichi Uwai
doaj +1 more source
Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins [PDF]
British Journal of Pharmacology, 2021 Background and PurposeThe metabolic activity of cytochrome P450 (CYP) 2D6 is highly variable and CYP2D6 genotypes insufficiently explain the extensive and intermediate metabolic phenotypes, limiting the prediction of drug response plus adverse drug reactions.
Claudia Neul +8 more
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