Results 91 to 100 of about 24,839 (187)

Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus.

The Journal of biological chemistry, 2001
To determine whether organic cation transporter (OCT) family members might mediate choline transport in choroid plexus (CP), the handling of choline by cloned transporters and by intact CP isolated from the adult rat was investigated. Expression of OCT1 and OCT2 in Xenopus oocytes increased hemicholinium-3-sensitive choline uptake.
D H, Sweet, D S, Miller, J B, Pritchard
openaire   +2 more sources

Exacerbation of Cisplatin Cellular Toxicity by Regulation of the Human Organic Cation Transporter 2 through Angiotensin II. [PDF]

Int J Mol Sci, 2022
Kantauskaite M, Hucke A, Snieder B, Ciarimboli G.   +3 more
europepmc   +1 more source

Structural basis of sodium ion-dependent carnitine transport by OCTN2

Nature Communications
Carnitine is essential for the import of long-chain fatty acids into mitochondria, where they are used for energy production. The carnitine transporter OCTN2 (novel organic cation transporter 2, SLC22A5) mediates carnitine uptake across the plasma ...
James S. Davies, Yi C. Zeng, Chelsea Briot, Simon H. J. Brown, Renae M. Ryan, Alastair G. Stewart   +5 more
doaj   +1 more source

Humanized Fruit Flies as a Novel Pre-Clinical Test Model for Membrane Drug Transporters

Frontiers in Bioscience-Landmark
Background: Membrane transport proteins are critical determinants of systemic and intracellular drug levels, thereby contributing substantially to drug response and/or adverse drug reactions. Therefore, the U.S.
Yiwen Wang, Jing Yang, Elke Schaeffeler, Simon U. Jaeger, Matthias Schwab, Anne T. Nies, Bernard Moussian   +6 more
doaj   +1 more source

Mechanisms of Sorafenib Resistance in HCC Culture Relate to the Impaired Membrane Expression of Organic Cation Transporter 1 (OCT1)

Journal of Hepatocellular Carcinoma
Srinivas Chava,1 Nergiz Ekmen,2 Pauline Ferraris,1 Yucel Aydin,2 Krzysztof Moroz,1 Tong Wu,1 Swan N Thung,3 Srikanta Dash1,2,4 1Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA; 2Department ...
Chava S, Ekmen N, Ferraris P, Aydin Y, Moroz K, Wu T, Thung SN, Dash S   +7 more
doaj  

Downregulation of basophil-derived IL-4 and in vivo TH2 IgE responses by serotonin and other organic cation transporter 3 ligands

, 2011
International audienceBACKGROUND:Murine basophils can contribute to the T(H)2 polarization of the immune response by providing rapidly large amounts of IL-4, which suggests that pharmacologic downregulation of this cytokine might provide a strategy to ...
Dy, Michel, Elke Schneider, Bricard-Rignault, Rachel, Levasseur, Mélanie, Jean-Marie Launay, Anne France Petit-Bertron, Mélanie Levasseur, Launay, Jean-Marie, Côté, Francine, Sophie Gautron, Salah Mecheri, François Machavoine, Schneider, Elke, Mecheri, Salah, Jean-Antoine Ribeil, Machavoine, François, Francine Côté, Gautron, Sophie, Rachel Bricard-Rignault, Petit-Bertron, Anne France, Ribeil, Jean-Antoine, Michel Dy   +21 more
core   +1 more source

A nucleoside-sensitive organic cation transporter in opossum kidney cells

, 1999
Renal secretion of organic cations and anions are pleiotropic, active processes in mammals. Some nucleosides such as deoxyadenosine (dAdo), 2-chlorodeoxyadenosine, and azidothymidine are secreted by human and rodent kidneys. Previous work (J. A.
J. Arly Nelson, Mamoru Sakurai, Rong Chen, Bih Fang Pan   +3 more
core   +1 more source

Properties of Transport Mediated by the Human Organic Cation Transporter 2 Studied in a Polarized Three-Dimensional Epithelial Cell Culture Model. [PDF]

Int J Mol Sci, 2021
Koepp TN, Tokaj A, Nedvetsky PI, Conchon Costa AC, Snieder B, Schröter R, Ciarimboli G.   +6 more
europepmc   +1 more source

Ontogeny of Hepatic Organic Cation Transporter-1 in Rat and Human [PDF]

The organic cation transporter (OCT)-1 mediates hepatic uptake of cationic endogenous compounds and xenobiotics. To date, limited information exists on how Oct1/OCT1 functionally develops with age in rat and human livers and how this would affect the ...
Fattah, Sarinj, Annaert, Pieter, Baes, Myriam, Allegaert, Karel; id_orcid, Shinde, Abhijit Babaji, Augustijns, Patrick   +5 more
core   +1 more source

Effect of Perinatal Low Protein Diet on the Expression of Renal Organic Cation Transporter 2 and Novel Organic Cation Transporter 2 in Adult Rats

Studies have established that there is a greater risk for onset of adult metabolic syndrome disease such as diabetes mellitus, hypertension, hyperlipidemia, and obesity in subjects born with low birth weight (LBW).
Nguyen, Paulina M.
core