Results 71 to 80 of about 24,839 (187)

Left ventricular noncompaction cardiomyopathy and short QT syndrome due to primary carnitine deficiency

Annals of Noninvasive Electrocardiology, 2023
We report the case of a 13‐year‐old female patient presenting with presyncope and palpitations. Her electrocardiogram revealed an abbreviation of the rate‐corrected QT interval with imaging showing significant left ventricular dysfunction.
Oliver P. Hanington, Catherine Armstrong, Germaine Pierre, Graham Stuart, Jules C. Hancox   +4 more
doaj   +1 more source

Fluorocholine Transport Mediated by the Organic Cation Transporter 2 (OCT2, SLC22A2): Implication for Imaging of Kidney Tumors [PDF]

Drug Metabolism and Disposition, 2018
[18F]fluorocholine is the fluorinated analogue of [11C]choline and is used in positron emission tomography (PET) to monitor tumor metabolic activity. While important to optimize its use and expand the clinical indications, the molecular determinants of fluorocholine cellular uptake are poorly characterized.
Visentin, Michele, Torozi, Angelo, Gai, Zhibo, Hausler, Stephanie, Li, Chao, Hiller, Christian, Schraml, Peter H, Moch, Holger, Kullak-Ublick, Gerd A   +8 more
openaire   +3 more sources

Impact of Expression Levels of Platinum-uptake Transporters Copper Transporter 1 and Organic Cation Transporter 2 on Resistance to Anthracycline/Taxane-based Chemotherapy in Triple-negative Breast Cancer

Breast Cancer: Basic and Clinical Research, 2015
Adding platinum drugs to anthracycline/taxane (ANC-Tax)-based neoadjuvant chemotherapy (NAC) improves pathological complete response (pCR) rates in triple-negative breast cancer (TNBC).
Risa Takeda, Ayano Naka, Naoki Ogane, Yoichi Kameda, Kae Kawachi, Satoru Shimizu, Shingo Kamoshida   +6 more
doaj   +2 more sources

Hydrogen Inhalation Protects against Ototoxicity Induced by Intravenous Cisplatin in the Guinea Pig

Frontiers in Cellular Neuroscience, 2017
Introduction: Permanent hearing loss and tinnitus as side-effects from treatment with the anticancer drug cisplatin is a clinical problem. Ototoxicity may be reduced by co-administration of an otoprotective agent, but the results in humans have so far ...
Anette E. Fransson, Marta Kisiel, Kristian Pirttilä, Curt Pettersson, Pernilla Videhult Pierre, Göran F. E. Laurell   +5 more
doaj   +1 more source

Comparison of "type I" and "type II" organic cation transport by organic cation transporters and organic anion-transporting polypeptides

, 2001
Previous inhibition studies with taurocholate and cardiac glycosides suggested the presence of separate uptake systems for small "type I" (system1) and for bulky "type II" (system2) organic cations in rat hepatocytes.
Groothuis, GMM, Meier, PJ, Meijer, D. K., Hermann Koepsell, Dirk K. F. Meijer, Groothuis, G. M., Muller, M, Meier, P. J., van Montfoort, J. E., Meijer, DKF, Peter J. Meier, Koepsell, H., Koepsell, H, Müller, M., Geny M. M. Groothuis, Jessica E. Van Montfoort, Van Montfoort, JE   +16 more
core   +1 more source

Regulation of human hepatic drug transporter activity and expression by diesel exhaust particle extract.

PLoS ONE, 2015
Diesel exhaust particles (DEPs) are common environmental air pollutants primarily affecting the lung. DEPs or chemicals adsorbed on DEPs also exert extra-pulmonary effects, including alteration of hepatic drug detoxifying enzyme expression.
Marc Le Vee, Elodie Jouan, Bruno Stieger, Valérie Lecureur, Olivier Fardel   +4 more
doaj   +1 more source

Loss-of-function polymorphisms in the organic cation transporter OCT1 are associated with reduced postoperative tramadol consumption.

, 2016
The organic cation transporter OCT1 (SLC22A1) mediates uptake and metabolism of the active tramadol metabolite (+)O-desmethyltramadol in the liver. In this study, the influence of OCT1 genetic polymorphisms on pharmacokinetics and analgesic efficacy of ...
Tzvetkov, Mladen Vassilev, Frank, Musshoff, Frank Stüber, Steffens, Michael, Stamer, Ulrike, Ulrike M. Stamer, Jürgen Brockmöller, Stamer, Ulrike M., Musshoff, Frank, Stüber, Frank, Mladen V. Tzvetkov, Michael Steffens, Frank Musshoff, Brockmöller, Jürgen, Tzvetkov, Mladen V   +14 more
core   +1 more source

Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3

, 2011
The herbicide paraquat (PQ) has increasingly been reported in epidemiological studies to enhance the risk of developing Parkinson's disease (PD). Furthermore, case-control studies report that individuals with genetic variants in the dopamine
Jacqueline Tibbett, Phillip M. Rappold, Jonathan A. Javitch, Kim Tieu, Mei Cui, Adrianne S. Chesser, Jonathan C. Grima, Lihua Duan, Namita Sen   +8 more
core   +1 more source

Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice [PDF]

, 2014
Pharmacokinetics and effects on skeletal muscle and physical performance of oral acetylcarnitine and propionylcarnitine are not well characterized. We therefore investigated the influence of oral acetylcarnitine, propionylcarnitine, and carnitine on body
Morand, Réjane, Handschin, Christoph, Hench, Jürgen, Felser, Andrea, Krähenbühl, Stephan, Bouitbir, Jamal, Frank, Stephan   +6 more
core   +1 more source

Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide

, 2015
Hyeon-Uk Jeong,1 Mihwa Kwon,2 Yongnam Lee,3 Ji Seok Yoo,3 Dae Hee Shin,3 Im-Sook Song,2 Hye Suk Lee1 1College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea; 2College of Pharmacy and Research Institute of Pharmaceutical Sciences ...
Lee HS, Jeong HU, Kwon M, Song IS, Lee Y, Shin DH, Yoo JS   +6 more
core