Results 61 to 70 of about 24,839 (187)

Assessment of the Drug Interaction Potential of Unconjugated and GalNAc3-Conjugated 2′-MOE-ASOs

Molecular Therapy: Nucleic Acids, 2017
Antisense oligonucleotides are metabolized by nucleases and drug interactions with small drug molecules at either the cytochrome P450 (CYP) enzyme or transporter levels have not been observed to date.
Colby S. Shemesh, Rosie Z. Yu, Mark S. Warren, Michael Liu, Mirza Jahic, Brandon Nichols, Noah Post, Song Lin, Daniel A. Norris, Eunju Hurh, Jane Huang, Tanya Watanabe, Scott P. Henry, Yanfeng Wang   +13 more
doaj   +1 more source

Repositioning of Lansoprazole as a Protective Agent Against Cisplatin-Induced Ototoxicity

Frontiers in Pharmacology, 2022
Cisplatin (CDDP) is a well-known chemotherapeutic drug approved for various cancers. However, CDDP accumulates in the inner ear cochlea via organic cation transporter 2 (OCT2) and causes ototoxicity, which is a major clinical limitation.
Eri Wakai, Kenji Ikemura, Toshiro Mizuno, Kazuhiko Takeuchi, Satoshi Tamaru, Masahiro Okuda, Yuhei Nishimura   +6 more
doaj   +1 more source

Stereoselectivity in the Membrane Transport of Phenylethylamine Derivatives by Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3

Biomolecules, 2022
Stereoselectivity is well known and very pronounced in drug metabolism and receptor binding. However, much less is known about stereoselectivity in drug membrane transport. Here, we characterized the stereoselective cell uptake of chiral phenylethylamine derivatives by human monoamine transporters (NET, DAT, and SERT) and organic cation transporters ...
Gebauer, Lukas, Rafehi, Muhammad, Brockmöller, Jürgen, Krause, Frank   +3 more
openaire   +5 more sources

Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2 [PDF]

SLAS Discovery, 2019
Organic cation transporters (OCTs) are membrane proteins with relevant physiological (because they accept neurotransmitters as substrate) and pharmacological (because of their interaction with drugs) roles. The human OCTs hOCT1 (SLC22A1/hOCT1) and hOCT2 (SLC22A2/hOCT2) are highly expressed in hepatic (hOCT1) and in renal and neuronal tissue (hOCT2 ...
Snieder, Beatrice, Brast, Sabine, Grabner, Alexander, Buchholz, Sven, Schröter, Rita, Spoden, Gilles A., Florin, Luise, Salomon, Johanna, Albrecht, Tobias, Barz, Vivien, Sparreboom, Alex, Ciarimboli, Giuliano   +11 more
openaire   +2 more sources

Beta-2 Adrenergic Agonists Are Substrates and Inhibitors of Human Organic Cation Transporter 1

, 2015
Beta-2-adrenergic agonists are first line therapeutics in the treatment of asthma and chronic obstructive pulmonary disease (COPD). Upon inhalation, bronchodilation is achieved after binding to beta(2)-receptors, which are primarily localized on airway ...
Hagos, Yohannes, Hosoya, Ken-ichi, Johanna J. Salomon, Annett Kühne, Salomon, Johanna J., Petzke, Soeren, Kuehne, Annett, Julia C. Gausterer, Carsten Ehrhardt, Ken-ichi Hosoya, Ehrhardt, Carsten, Yohannes Hagos, Gausterer, Julia C., Sören Petzke   +13 more
core   +1 more source

Interaction of Chitosan Derivatives with Organic Cation Transporter 1 and 2

The FASEB Journal, 2018
The present study was to investigate the interactions of chitosan derivatives including quaternized chitosan (QC), N‐benzyl‐N,O‐succinyl chitosan (BSCS), N‐naphthyl‐N,O‐succinyl chitosan (NSCS) and N‐octyl‐N,O‐succinyl chitosan (OSCS), with organic cation transporter 1 (OCT1) and OCT2.
Sirima Soodvilai, Warayuth Sajomsang, Varanuj Chatsudthipong, Sunhapas Soodvilai, Praneet Opanasopit   +4 more
openaire   +1 more source

Deficiency in the Organic Cation Transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in Mice Abolishes Renal Secretion of Organic Cations [PDF]

Molecular and Cellular Biology, 2003
The polyspecific organic cation transporters 1 and 2 (Oct1 and -2) transport a broad range of substrates, including drugs, toxins, and endogenous compounds. Their strategic localization in the basolateral membrane of epithelial cells in the liver, intestine (Oct1), and kidney (Oct1 and Oct2) suggests that they play an essential role in removing noxious
Johan W, Jonker, Els, Wagenaar, Sven, Van Eijl, Alfred H, Schinkel   +3 more
openaire   +2 more sources

sj-pdf-1-het-10.1177_09603271211047915 – Supplemental Material for Wedelolactone protects against cisplatin-induced nephrotoxicity in mice via inhibition of organic cation transporter 2

, 2021
Supplemental Material, sj-pdf-1-het-10.1177_09603271211047915 for Wedelolactone protects against cisplatin-induced nephrotoxicity in mice via inhibition of organic cation transporter 2 by Guangju Wang, Yajuan Bi, Hui Xiong, Tongwei Bo, Lifeng Han, Lijun ...
Yajuan Bi (9508802), Guangju Wang (11515054), Lijun Zhou (577469), Chunze Zhang (4630786), Hui Xiong (541837), Tongwei Bo (11515057), Youcai Zhang (175270), Lifeng Han (375604)   +7 more
core   +1 more source

Quercetin declines plasma exposure of metoprolol tartrate in the rat model

Journal of Advanced Pharmaceutical Technology & Research, 2014
The study was undertaken to evaluate the effect of quercetin on the pharmacokinetics of Metoprolol tartrate. A single dose in vivo pharmacokinetic study was carried out in rat models.
Siva R Challa, Venkatesh R Challa, Satheesh K Ragam   +2 more
doaj   +1 more source

Drug Transporter Expression and Activity in Human Hepatoma HuH-7 Cells

Pharmaceutics, 2016
Human hepatoma cells may represent a valuable alternative to the use of human hepatocytes for studying hepatic drug transporters, which is now a regulatory issue during drug development. In the present work, we have characterized hepatic drug transporter
Elodie Jouan, Marc Le Vée, Claire Denizot, Yannick Parmentier, Olivier Fardel   +4 more
doaj   +1 more source