Results 41 to 50 of about 24,839 (187)

Pharmacokinetic Interaction between Metformin and Verapamil in Rats: Inhibition of the OCT2-Mediated Renal Excretion of Metformin by Verapamil

Pharmaceutics, 2020
The incidence of hypertension in diabetic patients has been increasing and contributing to the high mortality of diabetic patients. Recently, verapamil use was found to lower fasting blood glucose levels in diabetic patients, which led to a new ...
Seung Yon Han, Young Hee Choi
doaj   +1 more source

Inhibition of Human Drug Transporter Activities by the Pyrethroid Pesticides Allethrin and Tetramethrin. [PDF]

PLoS ONE, 2017
Pyrethroids are widely-used chemical insecticides, to which humans are commonly exposed, and known to alter functional expression of drug metabolizing enzymes. Limited data have additionally suggested that drug transporters, that constitute key-actors of
Lisa Chedik, Arnaud Bruyere, Marc Le Vee, Bruno Stieger, Claire Denizot, Yannick Parmentier, Sophie Potin, Olivier Fardel   +7 more
doaj   +1 more source

Cysteine Accessibility in the Hydrophilic Cleft of Human Organic Cation Transporter 2 [PDF]

Journal of Biological Chemistry, 2006
Organic cation transporters (OCTs) are involved in the renal elimination of many cationic drugs and toxins. A hypothetical three-dimensional structure of OCT2 based on a homology model that used the Escherichia coli glycerol 3-phosphate transporter as a template has been described (Zhang, X., Shirahatti, N. V., Mahadevan, D., and Wright, S. H. (2005) J.
Ryan M, Pelis, Xiaohong, Zhang, Yodying, Dangprapai, Stephen H, Wright   +3 more
openaire   +2 more sources

In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor

Pharmacology Research & Perspectives, 2021
Zanubrutinib is a highly selective, potent, orally available, targeted covalent inhibitor (TCI) of Bruton's tyrosine kinase (BTK). This work investigated the in vitro drug metabolism and transport of zanubrutinib, and its potential for clinical drug–drug
Heather Zhang, Ying C. Ou, Dan Su, Fan Wang, Lai Wang, Srikumar Sahasranaman, Zhiyu Tang   +6 more
doaj   +1 more source

The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease

, 2005
Recent data suggest that polymorphisms in the organic cation transporter (OCTN) genes OCTN1 (SLC22A4) and OCTN2 (SLC22A5) represent disease-causing mutations within the IBD5 locus (chromosome 5q31).
Arnott, IDR, Tenesa, Albert, Tenesa, A, Anderson, Norman, Satsangi, Jack, Anderson, N, Nimmo, Elaine R, Satsangi, J, Drummond, Hazel, Ho, Gwo-Tzer, Arnott, Ian D R, Noble, Colin L, Smith, Linda, Ho, G-T, Nimmo, ER, Noble, CL, Smith, L, Drummond, H   +17 more
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The NorM MATE transporter from N. gonorrhoeae: insights into drug and ion Binding from atomistic molecular dynamics simulations

, 2014
The multidrug and toxic compound extrusion transporters extrude a wide variety of substrates out of both mammalian and bacterial cells via the electrochemical gradient of protons and cations across the membrane.
Khalid, Syma, Syma Khalid, Leung, Yuk Ming, Yuk Ming Leung, Holdbrook, Daniel A., Thomas J. Piggot, Piggot, Thomas J., Daniel A. Holdbrook   +7 more
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Transport of carnitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa [PDF]

Reproduction, 2007
Abstract Carnitine and acetylcarnitine are important for the acquisition of motility and maturation of spermatozoa in the epididymis. In this study, we examined the involvement of carnitine/organic cation transporter (OCTN) in carnitine and acetylcarnitine transport in epididymal spermatozoa of mice.
Daisuke, Kobayashi, Ikumi, Tamai, Yoshimichi, Sai, Kazuhiro, Yoshida, Tomohiko, Wakayama, Yasuto, Kido, Jun-Ichi, Nezu, Shoichi, Iseki, Akira, Tsuji   +8 more
openaire   +2 more sources

Stereoselectivity in Cell Uptake by SLC22 Organic Cation Transporters 1, 2, and 3

Journal of Medicinal Chemistry, 2023
Stereoselectivity can be most relevant in drug metabolism and receptor binding. Although drug membrane transport might be equally important for small-molecule pharmacokinetics, the extent of stereoselectivity in membrane transport is largely unknown.
Lukas Gebauer, Ole Jensen, Muhammad Rafehi, Jürgen Brockmöller   +3 more
openaire   +3 more sources

Cisplatin Nephrotoxicity Is Critically Mediated via the Human Organic Cation Transporter 2 [PDF]

The American Journal of Pathology, 2005
Cis-platin is an effective anti-neoplastic agent, but it is also highly nephrotoxic. Here, we clearly identify the human organic cation transporter 2 (hOCT2) as the critical transporter for cis-platin nephrotoxicity in isolated human proximal tubules and offer a potential mechanism for reducing nephrotoxicity in clinical practice.
Giuliano, Ciarimboli, Thomas, Ludwig, Detlef, Lang, Hermann, Pavenstädt, Hermann, Koepsell, Hans-Jürgen, Piechota, Jörg, Haier, Ulrich, Jaehde, Jochen, Zisowsky, Eberhard, Schlatter   +9 more
openaire   +2 more sources

Supplemental Data for Renal Secretion of Hydrochlorothiazide Involves Organic Anion Transporter 1/3, Organic Cation Transporter 2, and Multidrug and Toxin Extrusion Protein 2-K

, 2019
Supplemental Data for Renal Secretion of Hydrochlorothiazide Involves Organic Anion Transporter 1/3, Organic Cation Transporter 2, and Multidrug and Toxin Extrusion Protein 2-
David Wagner (6491240)
core   +1 more source