Results 51 to 60 of about 24,839 (187)

Characterisation and validation of drug transport and GLP-1R function in primary porcine proximal tubular cells [PDF]

, 2006
Overview kidney: Kidney is, beside the liver, one of the most important organs for the elimination of waste products, toxins, drugs and their metabolites. Due to the anatomy of the kidney, ultra filtrate leaving the glomerulus passes first the proximal
Schlatter, Philipp
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Atypical Substrates of the Organic Cation Transporter 1

, 2022
The human organic cation transporter 1 (OCT1) is expressed in the liver and mediates hepatocellular uptake of organic cations. However, some studies have indicated that OCT1 could transport neutral or even anionic substrates.
Redeker, Kyra-Elisa Maria, Ole Jensen, Jensen, Ole, Lukas Gebauer, Meyer-Tönnies, Marleen Julia, Kyra-Elisa Maria Redeker, Marleen Julia Meyer-Tönnies, Brockmöller, Jürgen, Gebauer, Lukas, Jürgen Brockmöller   +9 more
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Nilotinib concentration in cell lines and primary CD34+ chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters [PDF]

, 2009
Imatinib mesylate and nilotinib are highly effective at eradicating the majority of chronic myeloid leukemia (CML) cells; however, neither agent induces apoptosis of primitive CML CD34⁺ cells.
Holyoake, T.L., Davies, A., Jordanides, N.E., Giannoudis, A., Jorgensen, H.G., Harris, R.J., Hatziieremia, S., Mountford, J.C., Pirmohamed, M., Clark, R.E., Lucas, C.M.   +10 more
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Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells

Pharmaceutics
Proinflammatory cytokines, which are elevated during inflammation or infections, can affect drug pharmacokinetics (PK) due to the altered expression or activity of drug transporters and/or metabolizing enzymes.
Yik Pui Tsang, Tianran Hao, Qingcheng Mao, Edward J. Kelly, Jashvant D. Unadkat   +4 more
doaj   +1 more source

Caenorhabditis elegans organic cation transporter-2 is a novel drug uptake transporter that mediates induced mutagenesis by environmental genotoxic compounds

Journal of Radiation and Cancer Research, 2017
Uptake transporters are being studied for roles in the entry of therapeutic drugs into cells and thus can be exploited to improve the treatment of various diseases.
Dindial Ramotar
doaj   +1 more source

Islatravir Is Not Expected to Be a Victim or Perpetrator of Drug-Drug Interactions via Major Drug-Metabolizing Enzymes or Transporters

Viruses, 2021
Islatravir (MK-8591) is a nucleoside reverse transcriptase translocation inhibitor in development for the treatment and prevention of HIV-1. The potential for islatravir to interact with commonly co-prescribed medications was studied in vitro ...
Kelly Bleasby, Robert Houle, Michael Hafey, Meihong Lin, Jingjing Guo, Bing Lu, Rosa I. Sanchez, Kerry L. Fillgrove   +7 more
doaj   +1 more source

Protected and De-protected Platinum(IV) Glycoconjugates With GLUT1 and OCT2-Mediated Selective Cancer Targeting: Demonstrated Enhanced Transporter-Mediated Cytotoxic Properties in vitro and in vivo

Frontiers in Chemistry, 2018
Physiological characteristics of human malignancies are increased glycolysis and overexpression of glucose transporters (GLUTs). 18Flurodeoxyglucose-positron emission tomography (FDG-PET) has successfully developed as clinical modality for the diagnosis ...
Jing Ma, Hanfang Liu, Zhuoqing Xi, Jiuzhou Hou, Yingguang Li, Jie Niu, Tong Liu, Shuning Bi, Xin Wang, Chaojie Wang, Jiajia Wang, Songqiang Xie, Peng G. Wang   +12 more
doaj   +1 more source

Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin [PDF]

Pharmacogenetics and Genomics, 2009
The goal of this study was to determine the effect of a genetic variant in the organic cation transporter 2 (OCT2), OCT2-808G/T, which results in an amino acid change, A270S, on the pharmacokinetics of the antidiabetic drug, metformin.The uptake of metformin was performed in stably transfected HEK-293 cells expressing the empty vector (MOCK), the ...
Ying, Chen, Shuanglian, Li, Chaline, Brown, Stephen, Cheatham, Richard A, Castro, Maya K, Leabman, Thomas J, Urban, Ligong, Chen, Sook Wah, Yee, Ji Ha, Choi, Yong, Huang, Claire M, Brett, Esteban G, Burchard, Kathleen M, Giacomini   +13 more
openaire   +2 more sources

O envolvimento dos transportadores de monoaminas na captação de serotonina em veias [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaA serotonina (5-HT) é um neurotransmissor que está amplamente distribuído nos principais sistemas fisiológicos e ...
De Prá, Manuel Adalberto Alfaro
core  

Relevance of copper transporter 1 and organic cation transporters 1–3 for oxaliplatin uptake and drug resistance in colorectal cancer cells

, 2018
Copper transporter 1 and organic cation transporter 2 mediate oxaliplatin uptake in sensitive and resistant colorectal cancer cells. Organic cation transporter 1 is involved in oxaliplatin uptake only in sensitive cells underscoring its relevance for ...
G. V. Kalayda, I. Buß, M. U. Kassack, A. Hamacher, N. Sarin   +4 more
core   +1 more source