Results 31 to 40 of about 24,839 (187)
Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins
Journal of Pharmacological Sciences, 2008 Mycotoxins are secondary metabolites of moulds that which exert adverse effects in humans and animals. It is known that direct cellular toxicity is often associated with increased cellular accumulation of toxic compounds, and membrane transport may be ...
Kittipong Tachampa +9 more
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Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance
Pharmaceutics, 2020 The pharmacokinetics of a drug is dependent upon the coordinate work of influx transporters, enzymes and efflux transporters (i.e., transporter-enzyme interplay). The transporter–enzyme interplay may occur in liver, kidney and intestine.
Yiting Yang, Xiaodong Liu
doaj +1 more source
Association between the synonymous variant organic cation transporter 3 (OCT3)-1233G>A and the glycemic response following metformin therapy in patients with type 2 diabetes [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Organic cation transporter 3 (OCT3) as a high-capacity transporter contribute to the metabolism of metformin. The present study was conducted to determine the genotype frequencies of the variant OCT3-1233G>A (rs2292334) in patients with ...
Seyyedeh Raheleh Hosseyni-Talei +4 more
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Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]
, 2014 A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
core +1 more source
Pharmaceutics, 2021 Gastrointestinal tract absorption of cationic anticancer drugs and medicines was estimated using whole-body imaging following oral [123I]MIBG administration.
Masato Kobayashi +9 more
doaj +1 more source
Functional expression of the organic cation/carnitine transporter 2 in rat astrocytes [PDF]
Journal of Neurochemistry, 2006 AbstractIn this study, we sought to identify the transporters that mediate the uptake ofl‐carnitine and acetyl‐l‐carnitine in cultured rat cortical astrocytes.l‐[3H]carnitine and acetyl‐l‐[3H]carnitine uptake were both saturable, and mediated by a single Na+‐dependent transport system.
Masato, Inazu +5 more
openaire +2 more sources
Biochimie, 2004 Protein sequence alignments revealed one amino acid position, where organic cation transporters (OCTs, aspartate (D) at position 475 of rOCT2) and organic anion transporters (OATs, arginine (R) at position 466 of rOAT1) are charged oppositely. To address the impact of this amino acid for protein function we cloned rat organic cation transporter 2 ...
Bahn, Andrew +3 more
openaire +3 more sources
Molecules, 2013 The potent anti-hyperuricemia activities of Fructus Gardenia Extract (FGE) have been well reported. The aim of this study was to evaluate the uricosuric and nephro-protective effects of FGE and explore its possible mechanisms of action in oxonate-induced
Hui Ji +5 more
doaj +1 more source
Organic Cation Transporters in Human Physiology, Pharmacology, and Toxicology [PDF]
, 2020 Individual cells and epithelia control the chemical exchange with the surrounding environment by the fine-tuned expression, localization, and function of an array of transmembrane proteins that dictate the selective permeability of the lipid bilayer to ...
Gai, Zhibo; https://orcid.org/ +3 more
core +2 more sources
Biomolecules, 2019 The human organic cation transporter 2 (hOCT2) is highly expressed in proximal tubules of the kidneys, where it plays an important role in the secretion of organic cations.
Dominik Frenzel +6 more
doaj +1 more source