Results 11 to 20 of about 24,839 (187)

Identification of dequalinium as a potent inhibitor of human organic cation transporter 2 by machine learning based QSAR model [PDF]

Scientific Reports
Human organic cation transporter 2 (hOCT2/SLC22A2) is a key drug transporter that facilitates the transport of endogenous and exogenous organic cations.
Fumihiro Yamane, Kenji Ikemura, Masayoshi Kondo, Manami Ueno, Masahiro Okuda   +4 more
doaj   +4 more sources

Mechanism of Electrogenic Cation Transport by the Cloned Organic Cation Transporter 2 from Rat [PDF]

Journal of Biological Chemistry, 2000
The organic cation transporter 2 (OCT2) is expressed in plasma membranes of kidney and brain. Its transport mechanism and substrates are debated. We studied substrate-induced changes of electrical current with the patch clamp technique after expression of rat OCT2 in oocytes.
Budiman, T., Bamberg, E., Koepsell, H., Nagel, G.   +3 more
openaire   +4 more sources

Interaction of Cisplatin with the Human Organic Cation Transporter 2 [PDF]

Clinical Cancer Research, 2008
AbstractPurpose: Cisplatin is predominantly eliminated in the urine through active secretion. As the solute carrier organic cation transporter 2 (OCT2) is highly expressed in the basolateral membrane of proximal tubules, we determined its contribution to cisplatin transport and assessed the relation of variation in the gene encoding OCT2 (SLC22A2) with
Filipski, KK, Loos, Walter, Verweij, Jaap, Sparreboom, A   +3 more
openaire   +5 more sources

Colistin is Substrate of the Carnitine/Organic Cation Transporter 2 (OCTN2, SLC22A5) [PDF]

Drug Metabolism and Disposition, 2017
Colistin is a polycation antibiotic used for the treatment of multidrug-resistance (MDR) gram-negative infections; nevertheless, its use is often limited by the high incidence of renal damage. The mechanism underlying colistin-induced nephrotoxicity is not known, but perhaps related to its accumulation in the renal cortex upon extensive reabsorption ...
Visentin, Michele, Gai, Zhibo, Torozi, Angelo, Hiller, Christian, Kullak-Ublick, Gerd A   +4 more
openaire   +5 more sources

Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity [PDF]

Clinical Pharmacology & Therapeutics, 2009
Cisplatin is one of the most widely used anticancer agents for the treatment of solid tumors. The clinical use of cisplatin is associated with dose-limiting nephrotoxicity, which occurs in one-third of patients despite intensive prophylactic measures. Organic cation transporter 2 (OCT2) has been implicated in the cellular uptake of cisplatin, but its ...
Filipski, K K, Mathijssen, R H, Mikkelsen, Torben, Schinkel, A H, Sparreboom, A   +4 more
openaire   +5 more sources

Substance Delivery across the Blood-Brain Barrier or the Blood-Retinal Barrier Using Organic Cation Transporter Novel Type 2 (OCTN2)

Future Pharmacology
The membrane impermeability of a drug poses a significant challenge in drug research and development, preventing effective drug delivery to the target site.
Toshihiko Tashima
doaj   +2 more sources

Recent Advances in Molecular Pharmacology of the Histamine Systems: Organic Cation Transporters as a Histamine Transporter and Histamine Metabolism

Journal of Pharmacological Sciences, 2006
.: Histamine is inactivated by the histamine-metabolizing enzyme histamine N-methyl-transferase (HNMT) in bronchus, kidney, and the central nervous system.
Ogasawara Masahito, Yamauchi Kohei, Satoh Yoh-ichi, Yamaji Ryoichi, Inui Kenichi, Jonker Johan W., Schinkel Alfred H., Maeyama Kazutaka   +7 more
doaj   +2 more sources

Identification of functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2. [PDF]

PLoS ONE, 2014
Polyamine (putrescine, spermidine and spermine) and agmatine uptake by the human organic cation transporter 2 (hOCT2) was studied using HEK293 cells transfected with pCMV6-XL4/hOCT2.
Kyohei Higashi, Masataka Imamura, Satoshi Fudo, Takeshi Uemura, Ryotaro Saiki, Tyuji Hoshino, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarashi   +8 more
doaj   +2 more sources

Functional significance of conserved cysteines in the human organic cation transporter 2.

Am J Physiol Renal Physiol, 2012
The significance of conserved cysteines in the human organic cation transporter 2 (hOCT2), namely the six cysteines in the long extracellular loop (loop cysteines) and C474 in transmembrane helix 11, was examined. Uptake of tetraethylammonium (TEA) and 1-methyl-4-phenypyridinium (MPP) into Chinese hamster ovary cells was stimulated >20-fold by hOCT2
Pelis RM, Dangprapai Y, Cheng Y, Zhang X, Terpstra J, Wright SH.   +5 more
europepmc   +4 more sources

Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity

Acta Pharmaceutica Sinica B, 2021
Disease-mediated alterations to drug disposition constitute a significant source of adverse drug reactions. Cisplatin (CDDP) elicits nephrotoxicity due to exposure in proximal tubule cells during renal secretion.
Joseph L. Jilek, Kayla L. Frost, Kevyn A. Jacobus, Wenxi He, Erica L. Toth, Michael Goedken, Nathan J. Cherrington   +6 more
doaj   +1 more source