Results 21 to 30 of about 24,839 (187)
The Effect of Uremic Solutes on the Organic Cation Transporter 2 [PDF]
Journal of Pharmaceutical Sciences, 2017 Chronic kidney disease (CKD) is characterized by the accumulation of uremic solutes; however, little is known about how these solutes affect drug absorption and disposition. The goal of this study is to evaluate the effect of uremic solutes on the organic cation transporter, OCT2, which plays a key role in the renal secretion of many basic drugs.
Kit Wun Kathy, Cheung +6 more
openaire +2 more sources
Intestinal OCTN2- and MCT1-targeted drug delivery to improve oral bioavailability
Asian Journal of Pharmaceutical Sciences, 2020 Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs, thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.
Gang Wang +8 more
doaj +1 more source
Biochemical Pharmacology, 2022 Stereoselectivity is important in many pharmacological processes but its impact on drug membrane transport is scarcely understood. Recent studies showed strong stereoselective effects in the cellular uptake of fenoterol by the organic cation transporters OCT1 and OCT2.
Gebauer, Lukas +4 more
openaire +4 more sources
Molecules, 2021 Carnitine insufficiency is reported in type 1 diabetes mellitus. To determine whether this is accompanied by defects in biosynthesis and/or renal uptake, liver and kidney were obtained from male Sprague-Dawley rats with streptozotocin-induced diabetes ...
Aman Upadhyay +2 more
doaj +1 more source
Transport of Monoamine Transmitters by the Organic Cation Transporter Type 2, OCT2 [PDF]
Journal of Biological Chemistry, 1998 The recently cloned apical renal transport system for organic cations (OCT2) exists in dopamine-rich tissues such as kidney and some brain areas (Gründemann, D., Babin-Ebell, J., Martel, F., Ording, N., Schmidt, A., and Schömig, E. (1997) J. Biol. Chem. 272, 10408-10413).
D, Gründemann +7 more
openaire +2 more sources
Functional Involvement of the Organic Cation Transporter 2 (rOct2) in the Renal Uptake of Organic Cations in Rats [PDF]
Journal of International Medical Research, 2008 This study examined the contribution made by organic cation transporters (hOCT/rOct) to the saturable component of the renal uptake of 1-methyl-4-phenylpyridinium, tetraethylammonium (TEA), cimetidine and metformin into rOct2-expressing HEK293 cells and rat kidney slices.
K-I, Umehara +3 more
openaire +2 more sources
Current Research in Pharmacology and Drug Discovery, 2023 The high levels of bile acids are a critical factor in hepatorenal syndrome. Organic solute transporter α/β (Ostα/β) participate in bile acids reabsorption in the kidney.
Xiaojuan Zhao +6 more
doaj +1 more source
Interactions of organophosphate flame retardants with human drug transporters
Ecotoxicology and Environmental Safety, 2023 Organophosphate flame retardants (OPFRs) are environmental pollutants of increasing interest, widely distributed in the environment and exerting possible deleterious effects towards the human health. The present study investigates in vitro their possible
Valentin Tastet +6 more
doaj +1 more source
Analysis of carnitine and acylcaritines in biological fluids and application to a clinical study [PDF]
, 2005 Carnitine, an endogenous compound present in most mammalian tissues, is involved in the transport of activated fatty acids between cellular organelles and thus plays an important role in fatty acid metabolism and in cellular energy production ...
Vernez, Laurence
core +1 more source
, 2004 This case report describes ventricular fibrillation without overt cardiomyopathy as the presenting symptom of primary carnitine deficiency due to organic cation transporter 2 (OCTN2)-deficiency in a 15-year-old girl.
Beaufort-Krol, Gertie C. M. +8 more
core +4 more sources