Results 81 to 90 of about 24,839 (187)

Membrane Transporters as Mediators of Cisplatin Effects and Side Effects

Scientifica, 2012
Transporters are important mediators of specific cellular uptake and thus, not only for effects, but also for side effects, metabolism, and excretion of many drugs such as cisplatin.
Giuliano Ciarimboli
doaj   +1 more source

ROLE OF TRANSPORTERS IN THE DISTRIBUTION OF PLATINUM-BASED DRUGS

Frontiers in Pharmacology, 2015
Platinum derivatives used as chemotherapeutic drugs such as cisplatin and oxaliplatin have a potent antitumor activity. However, severe side effects such as nephro-, oto-, and neurotoxicity are associated with their use.
Saliha eHarrach, Giuliano eCiarimboli
doaj   +1 more source

Liver Fibrosis Stages Affect Organic Cation Transporter 1/2 Activities in Hepatitis C Virus-Infected Patients

Pharmaceuticals
This study aims to evaluate the impact of liver fibrosis stages of chronic infection with hepatitis C virus (HCV) on the in vivo activity of organic cation transporters (hepatic OCT1 and renal OCT2) using metformin (MET) as a probe drug.
Matheus De Lucca Thomaz, Carolina Pinto Vieira, Juciene Aparecida Caris, Maria Paula Marques, Adriana Rocha, Tiago Antunes Paz, Rosamar Eulira Fontes Rezende, Vera Lucia Lanchote   +7 more
doaj   +1 more source

Fat cells gobbling up norepinephrine?

PLoS Biology, 2019
The sympathetic nervous system (SNS) controls key aspects of adipose tissue (AT) function through the release of norepinephrine (NE) and beta adrenergic signaling.
Vitaly Ryu, Christoph Buettner
doaj   +1 more source

TURNOVER NUMBER OF ORGANIC CATION TRANSPORTER 2

, 2018
Organic Cation Transporter 2 (OCT2) is a transporter in the basolateral membrane of proximal tubular epithelial cells that plays a major role in active drug secretion.
Kuang, Kathy
core  

Efficient proximal tubule-on-chip model from hiPSC-derived kidney organoids for functional analysis of renal transporters

iScience
Summary: Renal transporters play critical roles in predicting potential drug-drug interactions. However, current in vitro models often fail to adequately express these transporters, particularly solute carrier proteins, including organic anion ...
Cheng Ma, Ramin Banan Sadeghian, Ryosuke Negoro, Kazuya Fujimoto, Toshikazu Araoka, Naoki Ishiguro, Minoru Takasato, Ryuji Yokokawa   +7 more
doaj   +1 more source

Allele frequency and genotype distribution of a common variant in the 3´-untranslated region of the SLC22A3 gene in patients with type 2 diabetes: Association with response to metformin

Journal of Research in Medical Sciences, 2016
Background: Organic cation transporter 3 (OCT3) is an excellent transporter for metformin, which is used as first-line therapy for type 2 diabetes (T2D). OCT3 genetic variants may influence the clinical response to metformin.
Maryam Ghaffari-Cherati, Abdolkarim Mahrooz, Mohammad Bagher Hashemi-Soteh, Seyyedeh Raheleh Hosseyni-Talei, Ahad Alizadeh, Saeid Mofid Nakhaei   +5 more
doaj   +1 more source

New Clues for Nephrotoxicity Induced by Ifosfamide: Preferential Renal Uptake via the Human Organic Cation Transporter 2

, 2010
Anticancer treatment with ifosfamide but not with its structural isomer cyclophosphamide is associated with development of renal Fanconi syndrome leading to diminished growth in children and bone problems in adults.
Giuliano Ciarimboli, Burckhardt, Gerhard, Vollenbroecker, Beate, Holle, Svenja Kristina, Hagos, Yohannes, Pavenstaedt, Hermann, Robert Kleta, Rainer Rossi, Herrmann, Edwin, Beate Vollenbröcker, Edwin Herrmann, Hermann Pavenstädt, Kleta, Robert, Stefan Reuter, Gerhard Burckhardt, Eberhard Schlatter, Reuter, Stefan, Ciarimboli, Giuliano, Schlatter, Eberhard, Stefan Bierer, Bierer, Stefan, Yohannes Hagos, Rossi, Rainer, Svenja Kristina Holle   +23 more
core   +1 more source

Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin. [PDF]

Int J Mol Sci, 2023
Hucke A, Schröter R, Ceresa C, Chiorazzi A, Canta A, Semperboni S, Marmiroli P, Cavaletti G, Gess B, Ciarimboli G.   +9 more
europepmc   +1 more source

Expression of drug transporters in intestine and blood [PDF]

, 2005
Proteins that are capable to transport molecules across membranes are fundamental for the accurate functioning of the body. Many diseases have their cause in a dysfunction of a particular transport protein.
Zimmermann, Christian
core   +1 more source