Results 101 to 110 of about 24,839 (187)

The influence of substrate structure on organic cation transport

, 2001
Using epifluorescence microscopy I have characterized the transport of the fluorescent organic cation NBD-TMA⁺, [2-(4-nitro-2,1,3-benzoxadiaxol-7-yl)aminoethyl]trimethylammonium.
Bednarczyk, Dallas Joesph
core  

Different affinities of inhibitors to the outwardly and inwardly directed substrate binding site of organic cation transporter 2

, 2003
The rat organic cation transporter 2 (rOCT2) was expressed in Xenopus laevis oocytes and cation-induced outward and inward currents were measured in whole cells and giant patches using voltage clamp techniques.
Gorbulev, V., Koepsell, H., Gorboulev, T., Volk, C., Nagel, G., Budiman, T.   +5 more
core   +1 more source

Cationic uremic toxins affect human renal proximal tubule cell functioning through interaction with the organic cation transporter

, 2013
Contains fulltext : 125521.pdf (Publisher’s version ) (Open Access)Several organic cations, such as guanidino compounds and polyamines, have been found to accumulate in plasma of patients with kidney failure due to inadequate renal ...
Schophuizen, C.M.S., Wilmer, Martijn J., Heuvel, L.P.W.J. van den, Masereeuw, R., Masereeuw, Rosalinde, Jansen, Jitske, Gustavsson, L., Wilmer, M.J.G., Hilgendorf, Constanze, Schophuizen, Carolien M. S., Jansen, J., Hoenderop, J.G.J., Hilgendorf, C., Gustavsson, Lena,, Lund University., Gustavsson, Lena, van den Heuvel, Lambert P., Hoenderop, Joost G. J.   +17 more
core   +1 more source

Structure-Guided Identification of Phytochemical OCT2 Inhibitors and Their Functional Relevance to Cisplatin-Induced Cytotoxicity

Pharmaceutics
Background: Organic cation transporter 2 (OCT2) mediates the renal uptake of cisplatin and is a principal contributor to its dose-limiting nephrotoxicity. Despite reports of OCT2 inhibition by various phytochemicals, the structure–activity relationships (
Hyerim Song, Kyeong-Ryoon Lee, Hui Li, Mi-Kyung Lee, Yoon-Jee Chae   +4 more
doaj   +1 more source

Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients

, 2012
PURPOSE: Knowledge of transporters responsible for the renal secretion of creatinine is key to a proper interpretation of serum creatinine and/or creatinine clearance as markers of renal function in cancer patients receiving chemotherapeutic agents ...
Pui, CH, Ciarimboli, G, Franke, RM, Massmann, V, Sprowl, JA, Schlatter, E, Yang, WJ, Lancaster, CS, Pavenstadt, H, Mathijssen, RHJ; id_orcid, Guckel, D, Relling, MV, Herrmann, E, Sparreboom, A, Mathijssen, RHJ   +14 more
core   +1 more source

A novel pathogenic variant in the carnitine transporter gene, SLC22A5, in association with metabolic carnitine deficiency and cardiomyopathy features

BMC Cardiovascular Disorders
Background Primary carnitine deficiency (PCD) denotes low carnitine levels with an autosomal recessive pattern of inheritance. Cardiomyopathy is the most common cardiac symptom in patients with PCD, and early diagnosis can prevent complications.
Amir Ghaffari Jolfayi, Niloofar Naderi, Serwa Ghasemi, Alireza Salmanipour, Sara Adimi, Majid Maleki, Samira Kalayinia   +6 more
doaj   +1 more source

Structural and functional study of the nitrate transporter, NrtA

, 2013
Membrane proteins play a crucial role in most cellular processes. Transporter integral proteins carry a whole variety of solute molecules across biological membranes.
Da Silva, Ingrid Rodrigues Nunes
core  

Structural basis of Na+-independent and cooperative transport in the L-carnitine/gamma-butyrobetaine antiporter CaiT

, 2011
Der L-Carnitin/gamma-Butyrobetain Antiporter CaiT ist ein Mitglied der Betain/Carnitin/Cholin Transporter (BCCT) Familie. Sekundärtransporter der BCCT Familie transportieren Substrate, die eine positiv-geladene quartäre Ammoniumgruppe besitzen.
Schulze, Sabrina
core  

Cadmium exposure enhances organic cation transporter 2 trafficking to the kidney membrane and exacerbates cisplatin nephrotoxicity. [PDF]

Kidney Int, 2020
Yang H, Tang J, Guo D, Zhao Q, Wen J, Zhang Y, Obianom ON, Zhou S, Zhang W, Shu Y.   +9 more
europepmc   +1 more source

Putative new biomarkers for renal transporter-mediated drug-drug interactions: Characterization as substrates of organic cation transporter 2, multidrug and toxin extrusion protein 1, and other important drug transporters. [PDF]

Drug Metab Dispos
Gessner A, Picurová J, Englhard L, Müller F, Fromm MF, König J.   +5 more
europepmc   +1 more source