Results 11 to 20 of about 55,182 (297)

Identification of dequalinium as a potent inhibitor of human organic cation transporter 2 by machine learning based QSAR model [PDF]

Scientific Reports
Human organic cation transporter 2 (hOCT2/SLC22A2) is a key drug transporter that facilitates the transport of endogenous and exogenous organic cations.
Fumihiro Yamane, Kenji Ikemura, Masayoshi Kondo, Manami Ueno, Masahiro Okuda   +4 more
doaj   +2 more sources

Identification of functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2. [PDF]

PLoS ONE, 2014
Polyamine (putrescine, spermidine and spermine) and agmatine uptake by the human organic cation transporter 2 (hOCT2) was studied using HEK293 cells transfected with pCMV6-XL4/hOCT2.
Kyohei Higashi, Masataka Imamura, Satoshi Fudo, Takeshi Uemura, Ryotaro Saiki, Tyuji Hoshino, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarashi   +8 more
doaj   +2 more sources

Functional significance of conserved cysteines in the human organic cation transporter 2.

Am J Physiol Renal Physiol, 2012
The significance of conserved cysteines in the human organic cation transporter 2 (hOCT2), namely the six cysteines in the long extracellular loop (loop cysteines) and C474 in transmembrane helix 11, was examined. Uptake of tetraethylammonium (TEA) and 1-methyl-4-phenypyridinium (MPP) into Chinese hamster ovary cells was stimulated >20-fold by hOCT2
Pelis RM, Dangprapai Y, Cheng Y, Zhang X, Terpstra J, Wright SH.   +5 more
europepmc   +4 more sources

Structural basis of sodium ion-dependent carnitine transport by OCTN2 [PDF]

Nature Communications
Carnitine is essential for the import of long-chain fatty acids into mitochondria, where they are used for energy production. The carnitine transporter OCTN2 (novel organic cation transporter 2, SLC22A5) mediates carnitine uptake across the plasma ...
James S. Davies, Yi C. Zeng, Chelsea Briot, Simon H. J. Brown, Renae M. Ryan, Alastair G. Stewart   +5 more
doaj   +2 more sources

Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity

Acta Pharmaceutica Sinica B, 2021
Disease-mediated alterations to drug disposition constitute a significant source of adverse drug reactions. Cisplatin (CDDP) elicits nephrotoxicity due to exposure in proximal tubule cells during renal secretion.
Joseph L. Jilek, Kayla L. Frost, Kevyn A. Jacobus, Wenxi He, Erica L. Toth, Michael Goedken, Nathan J. Cherrington   +6 more
doaj   +1 more source

Mechanism of Electrogenic Cation Transport by the Cloned Organic Cation Transporter 2 from Rat [PDF]

Journal of Biological Chemistry, 2000
The organic cation transporter 2 (OCT2) is expressed in plasma membranes of kidney and brain. Its transport mechanism and substrates are debated. We studied substrate-induced changes of electrical current with the patch clamp technique after expression of rat OCT2 in oocytes.
Budiman, T., Bamberg, E., Koepsell, H., Nagel, G.   +3 more
openaire   +3 more sources

Intestinal OCTN2- and MCT1-targeted drug delivery to improve oral bioavailability

Asian Journal of Pharmaceutical Sciences, 2020
Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs, thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.
Gang Wang, Lichun Zhao, Qikun jiang, Yixin Sun, Dongyang Zhao, Mengchi Sun, Zhonggui He, Jin sun, Yang Wang   +8 more
doaj   +1 more source

Interaction of Cisplatin with the Human Organic Cation Transporter 2 [PDF]

Clinical Cancer Research, 2008
AbstractPurpose: Cisplatin is predominantly eliminated in the urine through active secretion. As the solute carrier organic cation transporter 2 (OCT2) is highly expressed in the basolateral membrane of proximal tubules, we determined its contribution to cisplatin transport and assessed the relation of variation in the gene encoding OCT2 (SLC22A2) with
Filipski, KK, Loos, Walter, Verweij, Jaap, Sparreboom, A   +3 more
openaire   +3 more sources

Transport of Monoamine Transmitters by the Organic Cation Transporter Type 2, OCT2 [PDF]

Journal of Biological Chemistry, 1998
The recently cloned apical renal transport system for organic cations (OCT2) exists in dopamine-rich tissues such as kidney and some brain areas (Gründemann, D., Babin-Ebell, J., Martel, F., Ording, N., Schmidt, A., and Schömig, E. (1997) J. Biol. Chem. 272, 10408-10413).
D, Gründemann, S, Köster, N, Kiefer, T, Breidert, M, Engelhardt, F, Spitzenberger, N, Obermüller, E, Schömig   +7 more
openaire   +2 more sources

The Effects of Streptozotocin-Induced Diabetes and Insulin Treatment on Carnitine Biosynthesis and Renal Excretion

Molecules, 2021
Carnitine insufficiency is reported in type 1 diabetes mellitus. To determine whether this is accompanied by defects in biosynthesis and/or renal uptake, liver and kidney were obtained from male Sprague-Dawley rats with streptozotocin-induced diabetes ...
Aman Upadhyay, Kate E. Boyle, Tom L. Broderick   +2 more
doaj   +1 more source