Results 21 to 30 of about 55,182 (297)

Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity [PDF]

Clinical Pharmacology & Therapeutics, 2009
Cisplatin is one of the most widely used anticancer agents for the treatment of solid tumors. The clinical use of cisplatin is associated with dose-limiting nephrotoxicity, which occurs in one-third of patients despite intensive prophylactic measures. Organic cation transporter 2 (OCT2) has been implicated in the cellular uptake of cisplatin, but its ...
Filipski, K K, Mathijssen, R H, Mikkelsen, Torben, Schinkel, A H, Sparreboom, A   +4 more
openaire   +4 more sources

Fucoidan alleviates the hepatorenal syndrome through inhibition organic solute transporter α/β to reduce bile acids reabsorption

Current Research in Pharmacology and Drug Discovery, 2023
The high levels of bile acids are a critical factor in hepatorenal syndrome. Organic solute transporter α/β (Ostα/β) participate in bile acids reabsorption in the kidney.
Xiaojuan Zhao, Ting Yang, Jiayan Zhou, Yanli Chen, Qian Shen, Jiankang Zhang, Qianqian Qiu   +6 more
doaj   +1 more source

The Effect of Uremic Solutes on the Organic Cation Transporter 2 [PDF]

Journal of Pharmaceutical Sciences, 2017
Chronic kidney disease (CKD) is characterized by the accumulation of uremic solutes; however, little is known about how these solutes affect drug absorption and disposition. The goal of this study is to evaluate the effect of uremic solutes on the organic cation transporter, OCT2, which plays a key role in the renal secretion of many basic drugs.
Kit Wun Kathy, Cheung, Chia-Hsiang, Hsueh, Ping, Zhao, Timothy W, Meyer, Lei, Zhang, Shiew-Mei, Huang, Kathleen M, Giacomini   +6 more
openaire   +2 more sources

Variants in pharmacokinetic transporters and glycemic response to metformin:A metgen meta-analysis [PDF]

, 2017
Therapeutic response to metformin, a first-line drug for type 2 diabetes (T2D), is highly variable, in part likely due to genetic factors. To date, metformin pharmacogenetic studies have mainly focused on the impact of variants in metformin transporter ...
Becker, Becker, Becker, Buse, Chen, Chen, Choi, Christensen, Christensen, Christensen, Duca, Dujic, Foretz, Forslund, Giacomini, Goswami, Han, Hermann, Jablonski, Kahn, Kimura, Koepsell, Kusuhara, Liang, Manning, Masuda, McCreight, Müller, Nakamichi, Napolitano, Otsuka, Purcell, Shu, Shu, Song, Stage, Stocker, Tamai, Tkáč, Todd, Tzvetkov, Tzvetkov, Wang, Wang, Yoon, Zhou, Zhou, Zhou, Zhou   +48 more
core   +10 more sources

Organic Cation Transporter 3: A Cellular Mechanism Underlying Rapid, Non-Genomic Glucocorticoid Regulation of Monoaminergic Neurotransmission, Physiology, and Behavior [PDF]

, 2018
Corticosteroid hormones act at intracellular glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) to alter gene expression, leading to diverse physiological and behavioral responses.
Gasser, Paul J., Lowry, Christopher A.
core   +2 more sources

Functional Involvement of the Organic Cation Transporter 2 (rOct2) in the Renal Uptake of Organic Cations in Rats [PDF]

Journal of International Medical Research, 2008
This study examined the contribution made by organic cation transporters (hOCT/rOct) to the saturable component of the renal uptake of 1-methyl-4-phenylpyridinium, tetraethylammonium (TEA), cimetidine and metformin into rOct2-expressing HEK293 cells and rat kidney slices.
K-I, Umehara, T, Iwatsubo, K, Noguchi, H, Kamimura   +3 more
openaire   +2 more sources

Interactions of organophosphate flame retardants with human drug transporters

Ecotoxicology and Environmental Safety, 2023
Organophosphate flame retardants (OPFRs) are environmental pollutants of increasing interest, widely distributed in the environment and exerting possible deleterious effects towards the human health. The present study investigates in vitro their possible
Valentin Tastet, Marc Le Vée, Marie Kerhoas, Anna Zerdoug, Elodie Jouan, Arnaud Bruyère, Olivier Fardel   +6 more
doaj   +1 more source

Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters [PDF]

, 2010
Reabsorption of filtered solutes from the glomerular filtrate and excretion of waste products and xenobiotics are the main functions of the renal proximal tubular (PT) epithelium.
Martijn J. Wilmer, Moin A. Saleem, Rosalinde Masereeuw, Lan Ni, Thea J. van der Velden, Frans G. Russel, Peter W. Mathieson, Leo A. Monnens, Lambertus P. van den Heuvel, Elena N. Levtchenko, M Bens, H Birn, AG Bodnar, CD Brown, CJ Detrisac, CJ Detrisac, A Dorrenhaus, AA El-Sheikh, IC Forster, WA Gahl, M Gekle, M Gekle, KM Madsen, K Malmstrom, S Nielsen, J O'Brien, MJ O'Hare, LC Racusen, LC Racusen, SJ Reshkin, FG Russel, MJ Ryan, MA Saleem, SC Satchell, AC Stamps, S Terryn, RA Aubel van, FM Water van de, C Weiland, MJG Wilmer, YS Yang, XY Zhai   +41 more
core   +2 more sources

Mutation of amino acid 475 of rat organic cation transporter 2 (rOCT2) impairs organic cation transport

Biochimie, 2004
Protein sequence alignments revealed one amino acid position, where organic cation transporters (OCTs, aspartate (D) at position 475 of rOCT2) and organic anion transporters (OATs, arginine (R) at position 466 of rOAT1) are charged oppositely. To address the impact of this amino acid for protein function we cloned rat organic cation transporter 2 ...
Bahn, Andrew, Hagos, Yohannes, Rudolph, Tanja, Burckhardt, Gerhard   +3 more
openaire   +3 more sources

Colistin is Substrate of the Carnitine/Organic Cation Transporter 2 (OCTN2, SLC22A5) [PDF]

Drug Metabolism and Disposition, 2017
Colistin is a polycation antibiotic used for the treatment of multidrug-resistance (MDR) gram-negative infections; nevertheless, its use is often limited by the high incidence of renal damage. The mechanism underlying colistin-induced nephrotoxicity is not known, but perhaps related to its accumulation in the renal cortex upon extensive reabsorption ...
Visentin, Michele, Gai, Zhibo, Torozi, Angelo, Hiller, Christian, Kullak-Ublick, Gerd A   +4 more
openaire   +3 more sources