Results 121 to 130 of about 7,064,890 (397)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Bis-DCM Type Dyes: Convenient Method for Synthesis of 2-(2, 6-bis(4-(dialkylamino)styryl)-4H -pyran-4-ylidene) Malononitrile Derivatives [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2018
An efficient and convenient method for synthesis of 2,6-bis (4-(dialkylamino) styryl)-4H-pyran-4-one starting from 4- (dialkylamino) benzaldehyde with 2,6-dimethyl-4H-pyran-4-onein the presence of MeONa as the base was described.
Reza Teimuri-Mofrad, Negar Boroomand, Keshvar Rahimpour, Raha Hadi, Ahmad Poursadegh   +4 more
doaj  

Synthesis and precise deposition of gold nanoparticles using electrospray technique [PDF]

, 2015
The main dissertation subject is the study on new synthesis method of highly monodisperse gold nanoparticles in organic media and elaboration of nanoparticles deposition technique onto different substrates including memory devices.Praca naukowa ...
Rosowski, Marcin
core  

Theoretical study of Covalent Organic Frameworks based on C3-symmetric Central Cores [PDF]

, 2020
In recent years, the design and synthesis of COFs (covalent organic frameworks) has been deeply investigated. These materials are constructed from the union of different covalently linked conjugated platforms and they have a wide range of analytical ...
Gámez Valenzuela, Sergio, Gómez-Lor, Berta, Martínez Ruiz, Ignacio, Ruíz-Delgado, María del Carmen   +3 more
core  

Multistep Solid-State Organic Synthesis of Carbamate-Linked Covalent Organic Frameworks.

Journal of the American Chemical Society, 2019
Herein, we demonstrate the first example of a multistep solid-state organic synthesis, in which a new imine-linked two-dimensional covalent organic framework (COF-170, 1) was transformed through three consecutive postsynthetic modifications into porous ...
Steven J Lyle, Thomas M. Osborn Popp, Peter J. Waller, Xiaokun Pei, J. Reimer, O. Yaghi   +5 more
semanticscholar   +1 more source

Mechanochemistry for Organic and Inorganic Synthesis

ACS Organic & Inorganic Au
In recent years, mechanochemistry has become an innovative and sustainable alternative to traditional solvent-based synthesis. Mechanochemistry rapidly expanded across a wide range of chemistry fields, including diverse organic compounds and active pharmaceutical ingredients, coordination compounds, organometallic complexes, main group frameworks, and ...
Javier F. Reynes, Felix Leon, Felipe García   +2 more
openaire   +6 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

5-Hydroxymethylfurfural (HMF) in Organic Synthesis: A Review of its Recent Applications Towards Fine Chemicals.

Current Organic Synthesis, 2019
BACKGROUND 5-Hydroxymethylfurfural (5-HMF) is a biomass-derived platform chemical, which can be produced from carbohydrates. In the past decades, 5- HMF has received tremendous attention because of its wide applications in the production of various value-
Weigang Fan, C. Verrier, Y. Queneau, F. Popowycz   +3 more
semanticscholar   +1 more source

Synthesis and characterization of fluorine doped tin oxide nanoparticle: An efficient catalyst for the preparation of 14-aryl-14H dibenzo [a,j]xanthene under free organic solvents conditions [PDF]

, 2020
Ahmed, Awad Ibrahim, Eladl, M. M., El-Yazeed, W. S. Abo   +2 more
openalex   +1 more source