Results 61 to 70 of about 5,387,507 (383)

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Solvent-free, Environmentally Benign Syntheses of Some Imines and Antioxidant Activity

Orbital: The Electronic Journal of Chemistry, 2015
Environmentally benign, economically feasible, and solvent-free syntheses of series of imines by the condensation of a substituted hydroxynaphthyl ketone with several substituted iodoanilines under grinding approach are described.
Sainath B. Zangade, Avinash Shinde, Avinash Shinde, Shivaji Chavan, Shivaji Chavan, Yeshwant Vibhute, Yeshwant Vibhute   +6 more
doaj   +1 more source

Human Enzymes for Organic Synthesis [PDF]

Angewandte Chemie International Edition, 2018
AbstractHuman enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics.
Winkler, Margit; Geier, Martina; Hanlon, Steven P.; Nidetzky, Bernd; Glieder, Anton   +5 more
openaire   +3 more sources

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Synthesis of infinite-layer LaNiO2 films by metal-organic deposition [PDF]

, 2008
We report the synthesis of infinite-layer LaNiO2 thin films by metal organic decomposition. Our work is aimed to synthesize perovskite-like oxides with 3d9 electronic configuration, which is common to high-Tc copper oxides. The 3d9 configuration is very rare in oxides other than cuprates. Ni1+ oxides, even though Ni1+ is an unusual oxidation state, may
arxiv   +1 more source

Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures

Neurobiology of Disease, 2021
There is a growing body of evidence demonstrating the significant involvement of the sigma-1 chaperone protein in the modulation of seizures. Several sigma-1 receptor (Sig1R) ligands have been demonstrated to regulate the seizure threshold in acute and ...
Edijs Vavers, Baiba Zvejniece, Gundega Stelfa, Baiba Svalbe, Karlis Vilks, Einars Kupats, Rudolfs Mezapuke, Lasma Lauberte, Maija Dambrova, Liga Zvejniece   +9 more
doaj  

Two mutually complementary synthetic approaches towards 3-substituted 3,4-disubstituted and 1-(2-pyridyl)-substituted isoquinolines

Chimica Techno Acta, 2018
Two mutually complementary synthetic approaches towards 3- and 3,4-disubstituted 1-(2-pyridyl) isoquinolines were studied. The aryne-based method was successfully used for the obtaining of the corresponding the 3-cyano-1-(2-pyridyl)isoquinolines in one ...
I. L. Nikonov, D. S. Kopchuk, A. F. Khasanov, A. P. Krinochkin, E. S. Starnovskaya, Ya. K. Shtaiz, M. I. Savchuk, O. S. Tanya, G. V. Zyryanov, V. L. Rusinov, O. N. Chupakhin   +10 more
doaj   +1 more source

Zinc Acetate Catalyzed Stereoselective 1,2-trans-Glycosylation Using Glycosyl Chlorides

SynOpen, 2022
We report a strategy for the stereoselective synthesis of 1,2-trans-glycosides in the absence of neighboring group participation. The present protocol for the selective glycosylation mainly relies on catalyst control rather than protecting group ...
Mohammad Saif Ali, P. I. Ramesh, Subhash Ghosh, Madhu Babu Tatina   +3 more
doaj   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Proceedings 3rd Workshop on Horn Clauses for Verification and Synthesis [PDF]

EPTCS 219, 2016, 2016
This volume contains the proceedings of HCVS 2016, the Third Workshop on Horn Clauses for Verification and Synthesis which was held on April 3, 2016 in Eindhoven, The Netherlands as a satellite event of the European Joint Conferences on Theory and Practice of Software (ETAPS 2016).
arxiv   +1 more source