This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong +6 more
wiley +1 more source
How Does Digital Human Resource Management Foster a Sense of Relaxation Among Generation Z Employees? [PDF]
Zhang H, Hou X, Zhao S.
europepmc +1 more source
Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang +11 more
wiley +1 more source
Factors Affecting Job Satisfaction Among Diagnostic Radiography Technologists in Kuwait: A Mixed-Methods Research Study. [PDF]
Al-Qattan EM +4 more
europepmc +1 more source
Multi‐Axis Stretchable Zippers for Personalized Wound Healing
Multi‐axis stretchable zippers can adapt to complex wound morphologies and enable personalized wound treatment through programmable contraction. This morphological matching strategy helps accelerate wound closure, improve blood perfusion, promote epithelial regeneration, and enhance collagen remodeling, pioneering new directions for personalized and ...
Siyuan Cai +16 more
wiley +1 more source
Towards Healthy Work Environments: Development and Validation of the Nursing Organizational Well-Being Questionnaire-A Theory-Based Measure. [PDF]
Della Bella V, Fiorini J, Sili A.
europepmc +1 more source
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang +33 more
wiley +1 more source
The impact of unethical pro-organizational behavior on employee well-being. [PDF]
Wang J, Zhou Q, Wang M, Yan X.
europepmc +1 more source
Photonic‐Enabled Energy‐Efficient Transparent Neuromorphic Computing Devices: A Review
Transparent photonic neuromorphic computing devices merge optics and brain‐inspired computing to overcome von Neumann bottlenecks with ultrafast, low‐energy processing. By exploiting transparent oxides, 2D materials, phase‐change materials, and hybrid heterostructures, these platforms enable photonic synapses, memory, and logic for see‐through edge ...
Shuvaraj Ghosh +8 more
wiley +1 more source
Impact of artificial intelligence and work digitalization on mental health and occupational well-being: a scoping review. [PDF]
Rabasa-Martín Ó, Martínez-Jarreta B.
europepmc +1 more source

