Results 61 to 70 of about 154,070 (226)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Teacher leadership for organizational change
Management : Journal of Contemporary Management Issues, 2019 The aim of this article is to test the teacher leadership initiated by teacher professional development abroad, as a factor of organisational change in a structural equation model.
Milda Damkuvienė +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
SUSTAINABLE LEADERSHIP AND ORGANIZATIONAL SUSTAINABILITY THROUGH ORGANIZATIONAL CHANGE
Journal of Business Paradigms, 2017 leadership and organizational sustainability, securing it through the implementation of organizational changes. In reviewing the organizational sustainability in this paper as an object of treatment are the profit organizations whose organizational ...
Cvetko Smilevsk
doaj
Pendampingan Emosi dan Kemampuan Mengelola Emosi pada Karyawan yang Mengalami Perubahan Organisasi
JIP (Jurnal Intervensi Psikologi), 2017 Organizational change causes various reactions toward organizational members, include emotional reaction- The aim of this research is to improve the emotional management ability on organizational members that get into organizational change through ...
Nur Afni Indahari Arifin +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
FACTORS OF ORGANIZATIONAL CULTURE CHANGE
Ekonomika, 2009 Organizational culture has a significant impact on the organization members’ life and in general it helps a company to achieve positive financial results.
Violeta Raimonda Kulvinskienė +1 more
doaj +1 more source