Results 31 to 40 of about 217,468 (218)

Advancing inclusive science and systemic change: the convergence of national aims and institutional goals in implementing and assessing biomedical science training

open access: yesBMC Proceedings, 2017
Background and purpose National reports call for improving America’s leadership in scientific research, accelerating degree attainments, and diversifying the scientific workforce to foster innovation.
Sylvia Hurtado   +2 more
doaj   +1 more source

Factorial confirmatory analysis to measure the perception of labor inclusion of people with disabilities

open access: yesNova Scientia, 2021
Introduction: The objective of this scientific approach was to validate through confirmatory factor analysis a measurement model to determine the perceived importance of the inclusion of persons with disabilities in the labor market, in employees who ...
Saúl Pérez-Hernández   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The Impact of Ethical Plans on Job Satisfaction through Perceived Corporate Social Responsibility and Organizational Ethical Environment. [PDF]

open access: yesفرایند مدیریت و توسعه, 2020
While the Iranian community is perceived to be a religious and ethical community, the ethical challenges existing in the country's organizations suggest that ethics development cannot be achieved solely through preaching and promotional activities ...
Parivash Tahmasebi, Firouz Raznahan
doaj  

New territorial actors between exploration and conservation

open access: yesScienze del Territorio, 2022
The paper reflects on the evolution of ‘collective subjects’ and civil organizations promoting grassroots processes aimed at generating social innovation.
Giulia Li Destri Nicosia   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Street-Level Organizations and the "Real World" of Workfare: Lessons from the US

open access: yesSocial Work and Society, 2015
By the end of the 20th C., workfare and labor market activation policies had become increasingly common around the globe. These developments provoked debate over whether these policies were advancing a project of commodification (Esping-Andersen 1990) by
Evelyn Z. Brodkin
doaj   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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