Results 131 to 140 of about 69,048 (266)

Tetramethylpyrazine Confers Protection Against Oxidative Stress and NLRP3-Dependent Pyroptosis in Rats with Endometriosis

open access: yesOrganogenesis
Tetramethylpyrazine (TMP) has been confirmed to suppress inflammation in endometriosis (EMs). Herein, this study investigated whether and how TMP affected NLRP3 inflammasomes and oxidative stress in EMs. After establishment of an EMs rat model, rats were
Ke Xu   +3 more
doaj   +1 more source

MicroRNA 160 controls the auxin response factor–class III peroxidase module and couples salicylic acid and redox signaling networks in the potato hypersensitive response to potato virus Y

open access: yesNew Phytologist, EarlyView.
miR160 links salicylic acid, auxin, and redox signaling with the growth–defense trade‐off in the potato hypersensitive response to potato virus Y. Summary Hypersensitive response (HR) is an effector‐triggered immune response leading to pathogen restriction and local cell death.
Maja Križnik   +11 more
wiley   +1 more source

Optimization of TX-100/SDS-based decellularized vascular material using ultrasound and chemical treatment: evaluation of structure and biosafety

open access: yesOrganogenesis
Decellularized blood vessels with low immunogenicity and excellent biocompatibility are promising for tissue engineering and clinical applications.
Hongguang Chen   +6 more
doaj   +1 more source

mRNA Decay Mediates Evolution and Biological Functions in Plant Gene Expression

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT mRNA decay is a key post‐transcriptional regulatory mechanism that fine‐tunes plant development and stress adaptation through dynamic mRNA stability control, bridging fundamental biology and crop improvement. Current knowledge of mRNA decay mechanisms in plants, largely derived from Arabidopsis, is poorly generalisable across plant lineages ...
Haidan Wu   +3 more
wiley   +1 more source

MLPH/RAB3A accelerates the differentiation of pancreatic stem cells to islet β-cells to control blood glucose in diabetic rats

open access: yesOrganogenesis
Background This study aimed to determine the potential mechanism by which pancreatic stem cell-derived beta cells (PSCs-β) assist in the body's glucose-lowering capacity in type 1 diabetes (T1D) rats.Methods We screened the transcriptomic changes in the ...
Junling Shan, Huifeng Wang, Guangyu Zhu
doaj   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda   +5 more
wiley   +1 more source

Hypoxia and the cytoskeleton

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Callus induction and organogenesis from various explants in Vigna radiata (L.) Wilczek

open access: yes, 2005
556-560Effect of different growth regulators and their concentration on callus formation and organogenesis in various explants and callus was studied in mung bean [Vigna radiata (L.) Wilczek. 2,4-D and NAA alone or in combination with Kn supported callus
Kaviraj, C P   +2 more
core  

Human placental transfer of xenobiotics in health and disease: New approach methodologies for developmental and reproductive toxicology testing and mathematical modelling

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend New approach methodologies (NAMs) to test the pharmaco‐ and chemicokinetics of compound transfer across the human placental barrier in late pregnancy. Abstract This review addresses an important and timely topic at the intersection of placental biology with respect to barrier transfer kinetics, toxicology and mathematical ...
Paul Brownbill, Eleanor Doman
wiley   +1 more source

Single‐Cell Integration of Mouse Models of Autism Reveals Conserved Transcriptomic Signatures of Excitatory‐Inhibitory Imbalance and Glial Dysfunction

open access: yesGlia, Volume 74, Issue 12, December 2026.
Integrated scRNA‐seq from 11 ASD models reveals convergent E/I imbalance and glial dysfunction. Conserved astrocyte and oligodendrocyte dysregulation transcend model‐specific variability. Validated by human datasets. ABSTRACT The etiological heterogeneity of autism spectrum disorder (ASD) complicates identifying core molecular mechanisms.
João V. Nani   +3 more
wiley   +1 more source

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