Results 111 to 120 of about 69,048 (266)

Defining the role of αC helix interactions in the activation of the integrin αI domain

The FEBS Journal, EarlyView.
The α2I domain of the α2β1 integrin contains a distinctive αC helix and a conserved Arg288‐Glu318 ion pair that stabilizes the closed state of the domain. Disruption of this ion pair in the activated α2I variant unwinds the αC helix, which allows interaction with additional collagen‐binding sites increasing collagen binding.
Liisa Pösö, Tomi T. Airenne, Jarmo Käpylä, Hongmin Tu, Eva Bligt‐Lindén, Vimal Parkash, Jyrki Heino, Tiina A. Salminen   +7 more
wiley   +1 more source

SS-31 Targets NOS2 to Enhance Osteogenic Differentiation in Aged BMSCs by Restoring Mitochondrial Function

Organogenesis
This study delves into the rejuvenating effects of SS-31 on aged human Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSCs), focusing on its potential to restore their diminished osteogenic differentiation capacity, a critical issue in geriatric medicine
Sen Duan, Qindong Zhang, Jinqiang Zhu, Jiaming Wang   +3 more
doaj   +1 more source

Reactive oxygen species, antioxidants and the regulation of plant development

The FEBS Journal, EarlyView.
The regulation of axillary bud outgrowth by the interplay between phytohormone and redox signals. Axillary bud outgrowth is regulated by cellular energy status and the balance between phytohormones, notably abscisic acid (ABA) and gibberellic acid (GA).
Juwita R. Dewi, Christine H. Foyer, Michael J. Considine   +2 more
wiley   +1 more source

Usefulness of physcomitrella patens for studying plant organogenesis

, 2013
In this chapter, we review the main organogenesis features and associated regulation processes of the mossPhyscomitrella patens (P. patens) , the model plant for the Bryophytes.
Nogué, Fabien, Rameau, Catherine, Schaefer, Didier, Bonhomme, Sandrine   +3 more
core   +1 more source

Calcium Imaging in Vivo: How to Correctly Select and Apply Fiber Optic Photometric Indicators

Organogenesis
Fiber-photometric is a novel optogenetic method for recording neural activity in vivo, which allows the use of calcium indicators to observe and study the relationship between neural activity and behavior in free-ranging animals.
Lanxia Wu, Wenxuan Sun, Linjie Huang, Lin Sun, Jinhua Dou, Guohua Lu   +5 more
doaj   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source

The Role of Innate Lymphoid Cells in Autoimmune, Allergic and Infectious Diseases: A Systematic Review

Immunology, EarlyView.
This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann, Henrique R. Dal‐Pizzol, Louise M. Lückmann, Davi E. Salini, Bruna C. Hasckel, Mikaeli Minati, Bruno Kluwe‐Schiavon, Tatiana Barichello   +7 more
wiley   +1 more source

Exploring the associations of overweight and obesity with pregnancy outcomes in type 1 and type 2 diabetes: An Australian retrospective cohort study

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Objective To explore the associations of maternal overweight/obesity and pre‐pregnancy body mass index (BMI) on glycemia and pregnancy outcomes in women with pregestational type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM). Research Design and Methods We examined prospectively collected data (2010–2019) involving 264 singleton
Xi May Zhen, Glynis Ross, Amanda Gauld, Arianne Sweeting, Alberto Nettel‐Aguirre, Stephanie Noonan, Maria Constantino, Anna‐Jane Harding, Adam Mackie, Hend Chatila, Margaret McGill, Timothy Middleton, Ted Wu, Stephen M. Twigg, Jencia Wong   +14 more
wiley   +1 more source

A Review of the Risk Factors and Approaches to Prevention of Post-Reperfusion Syndrome During Liver Transplantation

Organogenesis
Post-reperfusion syndrome (PRS) is a severe and highly lethal syndrome that occurs after declamping the portal vein forceps during liver transplantation.
Qian Gao, Jin-Zhen Cai, He Dong
doaj   +1 more source

Embryonic and larval development of the endangered Chiapas killifish Tlaloc hildebrandi (Cyprinodontiformes: Profundulidae)

Journal of Fish Biology, EarlyView.
Abstract The early ontogeny of endemic freshwater fishes provides essential baseline biological information for conservation and management, particularly in species with restricted distributions and high vulnerability to habitat degradation, environmental change and population decline. This study presents the first detailed description of embryonic and
Rubén Alonso Contreras‐Tapia, Gabriela Garza‐Mouriño, María Elena Castellanos‐Páez, Marcela Ivonne Benítez‐Díaz Mirón, Jairo Arroyave, Alfonso Ángel González‐Díaz, Wilfredo A. Matamoros   +6 more
wiley   +1 more source