Results 11 to 20 of about 72,062 (325)
Embryo model completes gastrulation to neurulation and organogenesis
Nature, 2022 Embryonic stem (ES) cells can undergo many aspects of mammalian embryogenesis in vitro1–5, but their developmental potential is substantially extended by interactions with extraembryonic stem cells, including trophoblast stem (TS) cells, extraembryonic ...
G. Amadei +14 more
semanticscholar +1 more source
Primate gastrulation and early organogenesis at single-cell resolution
Nature, 2022 Our understanding of human early development is severely hampered by limited access to embryonic tissues. Due to their close evolutionary relationship with humans, nonhuman primates are often used as surrogates to understand human development but ...
Jinglei Zhai +16 more
semanticscholar +1 more source
Organ-On-A-Chip: An Emerging Research Platform
Organogenesis, 2023 In drug development, conventional preclinical and clinical testing stages rely on cell cultures and animal experiments, but these methods may fall short of fully representing human biology.
Nithin R +4 more
doaj +1 more source
Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis
Nature Biotechnology, 2021 Molecular profiling of single cells has advanced our knowledge of the molecular basis of development. However, current approaches mostly rely on dissociating cells from tissues, thereby losing the crucial spatial context of regulatory processes. Here, we
T. Lohoff +19 more
semanticscholar +1 more source
Organogenesis, 2023 Background Oral leukoplakia (OLK) and oral lichen planus (OLP) are common precancerous lesions of the oral mucosa. The role of circular RNAs (circRNAs) in OLK and OLP is unclear.
Jingwen Yang +4 more
doaj +1 more source
A spatiotemporal atlas of organogenesis in the development of orchid flowers
Nucleic Acids Research, 2022 Development of floral organs exhibits complex molecular mechanisms involving the co-regulation of many genes specialized and precisely functioning in various tissues and developing stages.
Chang Liu +7 more
semanticscholar +1 more source
Cell Therapy Approaches for Articular Cartilage Regeneration
Organogenesis, 2023 Articular cartilage is a common cartilage type found in a multitude of joints throughout the human body. However, cartilage is limited in its regenerative capacity.
Meagan J. Makarczyk
doaj +1 more source
Animal Research and One Health, EarlyView., 2023 In our study, we conducted circRNA expression profiling of Zhongwei goat skin exhibiting divergent curvature wool phenotypes at two developmental stages using the RNA‐seq. Functional verification assay demonstrated that circRNA8782 regulated fibroblast proliferation.
Yingxiao Su +9 more
wiley +1 more source
Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development
Organogenesis, 2023 It is known to all that Wnt signaling pathway plays an important role in the early development of tooth. Our previous research found that Wnt signaling pathway played crucial roles in dental development, and mutations in antagonist of Wnt signaling ...
Yuhan Song +4 more
doaj +1 more source
Nature Communications, 2021 Soft tissue trauma can result in aberrant osteochondral differentiation of local mesenchymal progenitor cells. Here the authors show that, in mice, soft tissue trauma results in NGF expression by perivascular cells, which leads to axonal invasion and ...
Seungyong Lee +23 more
doaj +1 more source