Results 11 to 20 of about 136,156 (356)
A single-cell transcriptome atlas profiles early organogenesis in human embryos
Nature Cell Biology, 2023 Xu et al. provide a single-cell transcriptomic atlas of 4–6 week human embryos, thereby profiling early human organogenesis. The early window of human embryogenesis is largely a black box for developmental biologists.
Yichi Xu +9 more
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Embryo model completes gastrulation to neurulation and organogenesis
Nature, 2022 Embryonic stem (ES) cells can undergo many aspects of mammalian embryogenesis in vitro1–5, but their developmental potential is substantially extended by interactions with extraembryonic stem cells, including trophoblast stem (TS) cells, extraembryonic ...
G. Amadei +14 more
semanticscholar +1 more source
Cytokinins – regulators of de novo shoot organogenesis
Frontiers in Plant Science, 2023 Plants, unlike animals, possess a unique developmental plasticity, that allows them to adapt to changing environmental conditions. A fundamental aspect of this plasticity is their ability to undergo postembryonic de novo organogenesis.
Ján Šmeringai +2 more
semanticscholar +1 more source
Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis
Nature Biotechnology, 2021 Molecular profiling of single cells has advanced our knowledge of the molecular basis of development. However, current approaches mostly rely on dissociating cells from tissues, thereby losing the crucial spatial context of regulatory processes. Here, we
T. Lohoff +19 more
semanticscholar +1 more source
Primate gastrulation and early organogenesis at single-cell resolution
Nature, 2022 Our understanding of human early development is severely hampered by limited access to embryonic tissues. Due to their close evolutionary relationship with humans, nonhuman primates are often used as surrogates to understand human development but ...
Jinglei Zhai +16 more
semanticscholar +1 more source
Hepatology Communications, 2022 Liver cancer is an aggressive cancer associated with a poor prognosis. Development of therapeutic strategies for liver cancer requires fundamental research using suitable experimental models. Recent progress in direct reprogramming technology has enabled
Takeshi Goya +6 more
doaj +1 more source
Organogenesis, 2023 Decellularized scaffolds are promising biomaterials for tissue and organ reconstruction; however, strategies to effectively suppress the host immune responses toward these implants, particularly those without chemical crosslinking, remain warranted ...
Makoto Hisanaga +14 more
doaj +1 more source
A spatiotemporal atlas of organogenesis in the development of orchid flowers
Nucleic Acids Research, 2022 Development of floral organs exhibits complex molecular mechanisms involving the co-regulation of many genes specialized and precisely functioning in various tissues and developing stages.
Chang Liu +7 more
semanticscholar +1 more source
Arthritis Research & Therapy, 2022 Background Osteoarthritis is a degenerative disease of the knee that affects 250 million people worldwide. Due to the rising incidence of knee replacement and revision surgery, there is a need for a nonsurgical treatment to reduce pain and improve ...
Kelly A. Kimmerling +3 more
doaj +1 more source
, 2010 Developmental lung biology is a field that has the potential for significant human impact: lung disease at the extremes of age continues to cause major morbidity and mortality worldwide. Understanding how the lung develops holds the promise that investigators can use this knowledge to aid lung repair and regeneration. In the decade since the "molecular
David, Warburton +13 more
openaire +2 more sources