Results 161 to 170 of about 114,312 (393)
Organoids: a Special Issue [PDF]
Development, 2017 Summary: This Editorial provides an overview of the entire contents of the Special Issue, highlighting some of the important findings and major themes therein.
openaire +4 more sources
Advanced Healthcare Materials, EarlyView.An engineered microtissue model is developed and optimized to investigate human liver development. Extracellular matrix composition and mechanical forces are tuned using high‐throughput assays. Human induced pluripotent stem cells serve as the cellular source, enabling the observation of de novo patterned differentiation.
Ishita Jain +5 more
wiley +1 more source
Advanced ScienceRepairing large bone defects remains a major challenge, as current strategies—including autografts, allografts, and tissue‐engineered scaffolds—are limited by donor shortage, suboptimal biocompatibility, and insufficient control of the regenerative ...
Anfu Deng +12 more
doaj +1 more source
A Human Neural Tube Model Using 4D Self‐Folding Smart Scaffolds
Advanced Healthcare Materials, EarlyView.Induced pluripotent stem cells (iPSCs) exhibit features comparable to the inner cell mass of the human embryo. iPSCs are applied to a novel self‐folding 4D‐Neural Tube (4D‐NT) structure that mimics the neurulation process. This 4D‐NT model recapitulates early events of human neural development and represents a platform to explore neurodevelopmental ...
Claudia Dell'Amico +8 more
wiley +1 more source
The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. [PDF]
, 2020 The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex multi-cellular organ that intimately links with the cardiovascular system to accomplish gas exchange.
Basil, Maria C +15 more
core +1 more source
Advanced Healthcare Materials, EarlyView.The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Adequate thickness of the uterine lining is crucial for women with thin or damaged endometrium to achieve pregnancies. Endometrial mesenchymal stem cells (eMSC) can facilitate the cyclical repair and regeneration of the human endometrium. In this study, the human endometrium derived extracellular matrix hydrogel supports the growth of eMSC promoting ...
Jingwen Xu +9 more
wiley +1 more source
Self-organization and symmetry breaking in intestinal organoid development
Nature, 2019 Intestinal organoids are complex three-dimensional structures that mimic the cell-type composition and tissue organization of the intestine by recapitulating the self-organizing ability of cell populations derived from a single intestinal stem cell ...
Denise Serra +11 more
semanticscholar +1 more source
CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma. [PDF]
, 2020 BackgroundLong non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy.
Akeson, Mark +20 more
core +1 more source