Results 231 to 240 of about 90,274 (350)

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Beyond the amyloid hypothesis: leveraging human-centered complex <i>in vitro</i> models to decode Alzheimer's disease etiology. [PDF]

Front Toxicol
Price M, Pistollato F.
europepmc   +1 more source

Analysis of organoid and immune cell co-cultures by machine learning-empowered image cytometry [PDF]

Philipp Stüve, Benedikt Nerb, Selina Harrer, Marina Wuttke, Markus Feuerer, Henrik Junger, Elke Eggenhofer, Bianca Lungu, Simina Laslau, Uwe Ritter   +9 more
openalex   +1 more source

ORGANOID MODELS TO STUDY THE CROSSTALK BETWEEN TUMOR CELLS AND TUMOR INFILITRATING LYMPHOCYTES

, 2020
Claudia D’Oria
openalex   +2 more sources

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

Application and challenges of tumor organoid technology in precision immunotherapy. [PDF]

Front Immunol
Zhao X, Gao J, Liu Y, Shi Y, Zhang M, Zhang C, Chen J.   +6 more
europepmc   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Mechanochemical bistability of intestinal organoids enables robust morphogenesis [PDF]

Shi-Lei Xue, Qiutan Yang, Prisca Liberali, Édouard Hannezo   +3 more
openalex   +1 more source

HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4

Advanced Science, EarlyView.
This study reveals that the tyrosine metabolic enzyme HPD functions as a previously uncharacterized, METTL3‐independent m6A methyltransferase. It promotes colorectal tumor progression by coordinately regulating the SLC7A11/GPX4 axis to suppress ferroptosis.
Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo, Chunze Zhang, Shuai Zhang, Changliang Shan   +17 more
wiley   +1 more source

Rotational migration in human pancreatic ductal organoids depends on actin and myosin activity. [PDF]

Commun Biol
Xie G, Modak C, Usman OH, Tan RWF, Coca N, De Jesus G, Wang YJ, Thirumalai D, Li X, Irianto J.   +9 more
europepmc   +1 more source