Results 271 to 280 of about 90,274 (350)

Optimized patient-derived lung cancer organoids recapitulating the immune landscape for precision therapy evaluation. [PDF]

Cell Oncol (Dordr)
Xing H, Liu R, Chen Y, Chen X, Gao X, Shen C, Zhang S, Tang Y, Wu L, You M, Xu P, Xia B.   +11 more
europepmc   +1 more source

Conformable Device for Independent Measurements of Mucosal and Vascular Barriers in a Complex In Vitro Intestinal Model

Advanced Science, EarlyView.
Development of more complex in vitro models necessitates the development of improved monitoring approaches. This work demonstrates a novel conformable device capable of measuring the resistance of two cell barriers within a single model independently, a significant advantage over conventional trans‐epithelial/endothelial electrical resistance (TEER ...
Alexandra Elisabeth Wheeler, Sonja Blasche, Rob Bradley, Rachana Acharya, Sophie Oldroyd, David Bulmer, Kiran R. Patil, Róisín Meabh Owens   +7 more
wiley   +1 more source

How human-derived brain organoids are built differently from brain organoids derived from genetically-close relatives: a multi-scale hypothesis.

Soft Matter
Zhang T, Gupta S, Lancaster MA, Schwarz JM.   +3 more
europepmc   +1 more source

Patient-derived organoids in non-small cell lung cancer: advances in drug sensitivity testing. [PDF]

Front Pharmacol
Tang W, Tian X.
europepmc   +1 more source

ALDOA‐Mediated Metabolic Reprogramming is a Targetable Vulnerability for Ferroptosis Sensitization in Cancer

Advanced Science, EarlyView.
ALDOA‐depletion‐mediated glycolytic reprogramming promotes autophagy‐mediated degradation of MBOAT2, increasing the ratio of phospholipids containing pro‐ferroptotic polyunsaturated fatty acids over anti‐ferroptotic monounsaturated fatty acids, and thus sensitizing cancer cells to ferroptosis.
Pengqi Wang, Kezhang He, Bowen Wang, Wei Zhou, Ying Zhang, Tianhua Ma, Sheng Ding   +6 more
wiley   +1 more source

Periosteum Organoid: Biomimetic Design Inspired From the Bone Healing Process. [PDF]

Exploration (Beijing)
Hao S, Wang F, Huang J, Xia Z, Triffitt JT, Xu C, Bai L, Su J.   +7 more
europepmc   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Construction and application of pancreatic exocrine organoid and spheroid for drug screening and precision medicine. [PDF]

Front Cell Dev Biol
Tan X, Huang B, Yang X, Wang P, Hu L.
europepmc   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

Cadherin-1-mediated communication at the leader-follower boundary controls mouse breast tumor organoid collective migration. [PDF]

Cell Rep
Morikis VA, Avila DB, DiMauro A, Cao Y, Hwang PY, Pathak A, Longmore GD.   +6 more
europepmc   +1 more source