Results 271 to 280 of about 114,312 (393)

In vitro generation of human pluripotent stem cell derived lung organoids

, 2015
Briana R. Dye, David R. Hill, Michael A.H. Ferguson, Yu-Hwai Tsai, Melinda Nagy, Rachel Dyal, James M. Wells, Christopher N. Mayhew, Roy Nattiv, Ophir D. Klein, Eric S. White, Gail Deutsch, Jason R. Spence   +12 more
openalex   +1 more source

Dynamic Arginine Methylation of YBX1 Relay Controls Its Phase Separation and Chemoradiotherapy Resistance in Rectal Cancer

Advanced Science, EarlyView.
Protein arginine methyltransferase 3 (PRMT3) induces the arginine methylation of Y‐box binding protein 1 (YBX1), which suppresses phase separation and is imperative for its nuclear translocation. Subsequently, lysine‐specific demethylase 4A demethylates YBX1 to unmask the R247 residue and promote its phase separation, which transcriptionally regulates ...
Yunxing Shi, Taixuan Wan, Shaoru Liu, Huashan Liu, Ziwei Zeng, Wenxin Li, Zhenxing Liang, Li Xiong, Shuanglin Luo, Yunfei Yuan, Liang Huang, Liang Kang   +11 more
wiley   +1 more source

Charting bioethical frontiers: China's human organoid guidelines in a global context. [PDF]

Mil Med Res
Zhou LB, Lei YT, Han XX.
europepmc   +1 more source

Organoids as a Model for Colorectal Cancer [PDF]

, 2016
Madeleine A. Young, Karen R. Reed
openalex   +1 more source

Single‐Cell Transcriptomics Reveals ITGA2‐Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis

Advanced Science, EarlyView.
This study unveils ITGA2⁺ tumor cells as key drivers of pediatric thyroid cancer aggressiveness. These cells orchestrate dual oncogenic pathways: GLUT1‐mediated glycolytic reprogramming and M2 macrophage polarization. This metabolic‐immunological crosstalk promotes tumor progression and metastasis.
Zhi‐jun Zhan, Ning Li, Yan Sun, Lu Chen, Jun‐da Yin, Yun‐han Shan, Jia‐xing Zeng, Zhe‐cheng Li, Hai‐long Tan, Neng Tang, Shi Chang, Peng Huang   +11 more
wiley   +1 more source

Patient-derived organoid-guided precision therapy for a very young woman with multidrug-resistant metastatic breast cancer: a case report. [PDF]

Front Oncol
Zhang X, Zhang Z, Chen Y, Xu Y, Sun M.
europepmc   +1 more source

Single‐Nucleus RNA Sequencing Reveals Mid‐Gestational Neurodevelopment Features in the Superior Temporal Plane from Fetuses with Nonsyndromic Cleft Lip and Palate

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong, Xin‐Wei Huang, Qiu‐Xia Xiao, Ying‐Gang Zheng, Hao‐Yue Qin, Chang‐Le Fang, Li Chen, Ruo‐Lan Du, Qiu‐Lin Wang, Li‐Ren Huangfu, Ye‐Qing Fei, Yang‐Yang Zhao, Chen‐Yang Zhai, Ze‐Mian Chen, Shi‐Kun Yuan, Yu‐Ji Zhou, Xing‐Man He, Ting‐Ting Zhi, Xiao‐He Tian, Ting‐Hua Wang   +19 more
wiley   +1 more source

Organoid Modeling of the Tumor Immune Microenvironment

Cell, 2018
James T. Neal, Xingnan Li, Junjie Zhu, Valeria Giangarrà, Caitlin L. Grzeskowiak, Ji-hang Ju, Iris H. Liu, S. Chiou, A. Salahudeen, Amber R. Smith, B. Deutsch, Lillian Liao, Allison J. Zemek, Fan Zhao, Kasper Karlsson, Liora M. Schultz, Thomas J. Metzner, L. Nadauld, Yuen-Yi Tseng, Sahar Alkhairy, Coyin Oh, P. Keskula, D. Mendoza-Villanueva, Francisco Vega, P. Kunz, J. Liao, J. Leppert, J. Sunwoo, C. Sabatti, J. Boehm, W. Hahn, Grace X. Y. Zheng, Mark M. Davis, C. Kuo   +33 more
semanticscholar   +1 more source

Recent advances in applications of nanoparticles and decellularized ECM for organoid engineering. [PDF]

Mater Today Bio
Lee SJ, Cho JY, Heo TH, Yang DH, Chun HJ, Yoon JK, Jeong GJ.   +6 more
europepmc   +1 more source

PCSK9 Loss‐of‐Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects

Advanced Science, EarlyView.
PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li, Rui Wang, Wenting Luo, Hui Gu, Tianchu Huang, Qiushi Wang, Zhengwei Yuan   +6 more
wiley   +1 more source