Results 81 to 90 of about 114,312 (393)

Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids [PDF]

, 2019
Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Alex, Alpha L., Booth, Kevin T., Hashino, Eri, Koehler, Karl R., Lee, Jiyoon, Nelson, Rick F., Nie, Jing, Roth, Adam A., Tang, Pei-Ciao   +8 more
core   +1 more source

AI‐organoid integrated systems for biomedical studies and applications

Bioengineering & Translational Medicine
In this review, we explore the growing role of artificial intelligence (AI) in advancing the biomedical applications of human pluripotent stem cell (hPSC)‐derived organoids.
Sudhiksha Maramraju, Andrew Kowalczewski, Anirudh Kaza, Xiyuan Liu, J. Singaraju, Mark V. Albert, Zhen Ma, Huaxiao Yang   +7 more
semanticscholar   +1 more source

Single-cell brain organoid screening identifies developmental defects in autism

bioRxiv, 2022
The development of the human brain involves unique processes (not observed in many other species) that can contribute to neurodevelopmental disorders^ 1 – 4 . Cerebral organoids enable the study of neurodevelopmental disorders in a human context. We have
Chong Li, J. S. Fleck, Catarina Martins-Costa, T. Burkard, Marlene Stuempflen, Ábel Vértesy, A. Peer, Christopher Esk, U. Elling, Gregor Kasprian, Nina S. Corsini, Barbara Treutlein, Juergen A. Knoblich   +12 more
semanticscholar   +1 more source

Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo [PDF]

, 2017
While the use of bioluminescent proteins for molecular imaging is a powerful technology to further our understanding of complex processes, fluorescent labeling with visible light fluorescent proteins such as GFP and RFP suffers from poor tissue ...
Blyth, Karen, Cheung, Eric C., Hock, Andreas K., Humpton, Timothy J., Lee, Pearl, McGhee, Ewan, Monteverde, Tiziana, Murphy, Daniel J., Paulus-Hock, Viola, Scopelliti, Alessandro, Strathdee, Douglas, Vousden, Karen H.   +11 more
core   +1 more source

Stem cells for organoids

Smart Medicine, 2022
AbstractOrganoids are three‐dimensional (3D) cell culture systems that simulate the structures and functions of organs, involving applications in disease modeling, drug screening, and cellular developmental biology. The material matrix in organoids can provide a 3D environment for stem cells to differentiate into different cell types and continuously ...
Shutong Qian, Jiayi Mao, Zhimo Liu, Binfan Zhao, Qiuyu Zhao, Bolun Lu, Liucheng Zhang, Xiyuan Mao, Liying Cheng, Wenguo Cui, Yuguang Zhang, Xiaoming Sun   +11 more
openaire   +3 more sources

Organoid bioinks: construction and application

Biofabrication
Organoids have emerged as crucial platforms in tissue engineering and regenerative medicine but confront challenges in faithfully mimicking native tissue structures and functions.
Fuxiao Wang, Peiran Song, Jian Wang, Sicheng Wang, Yuanyuan Liu, Long Bai, Jiachan Su   +6 more
semanticscholar   +1 more source

Biofabrication of pheochromocytoma and paraganglioma tumor organoids and assessment of response to systemic therapy

Scientific Reports
Introduction Pheochromocytoma (PCC) and paraganglioma (PG) research is limited due to rarity of disease. We utilized patient-derived tumor organoids (PTOs) to explore personalized treatment options for these patients.
Richard A. Erali, Steven D. Forsythe, Cecilia R. Schaaf, Nicholas Edenhoffer, William Meeker, Cristian D. Valenzuela, Wencheng Li, Shay Soker, Reese W. Randle, Konstantinos I. Votanopoulos   +9 more
doaj   +1 more source

Recipe for pituitary organoids

Frontiers in Endocrinology, 2023
Generation of a variety of organs and tissues from human pluripotent stem cells (hPSCs) has been attempted in vitro. We here present a simple and efficient method for induction of hypothalamic and pituitary tissues from hPSCs. On provision of exogenous agents important for early hypothalamus-pituitary organogenesis, including bone morphogenetic protein
Mayuko Kano, Hiroo Sasaki, Tsutomu Miwata, Hidetaka Suga   +3 more
openaire   +3 more sources

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery

Science Advances, 2022
Organoids serve as a novel tool for disease modeling in three-dimensional multicellular contexts. Static organoids, however, lack the requisite biophysical microenvironment such as fluid flow, limiting their ability to faithfully recapitulate disease ...
Ken Hiratsuka, Tomoya Miyoshi, Katharina T. Kroll, Navin R Gupta, M. T. Valerius, Thomas C. Ferrante, M. Yamashita, J. Lewis, Ryuji Morizane   +8 more
semanticscholar   +1 more source